scholarly journals No effects of ozonated autohemotherapy on inflammation response in hemodialyzed patients

2004 ◽  
Vol 13 (5-6) ◽  
pp. 377-380 ◽  
Author(s):  
Leszek Tylicki ◽  
Bogdan Biedunkiewicz ◽  
Dominik Rachon ◽  
Tomasz Nieweglowski ◽  
Lukasz Hak ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Ozone Concentration ◽  
Interleukin 6 ◽  
Statistical Difference ◽  
Arterial Disease ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Markers Of Inflammation ◽  
Peripheral Arterial

BACKGROUND: Ozone as a strong oxidant may induce an inflammatory response.Aim: The hypothesis was verified as to whether ozonated autohemotherapy using an ozone dose in therapeutic range changes the plasma concentration of C-reactive protein and interleukin-6, markers of inflammation.Methods: In a controlled, single-blind, cross-over study, 12 chronically hemodialyzed patients with peripheral arterial disease were exposed to nine sessions of autohemotherapy with blood exposure to oxygen as a control followed by nine sessions of ozonated autohemotherapy with an ozone concentration of 50 μg/ml.Results: There was no statistical difference between C-reactive protein levels at baseline (1.53±1.01 mg/l), after nine sessions of control autohemotherapy (1.48±0.96 mg/l), and after nine sessions of ozonated autohemotherapy (1.55±0.84 mg/l). There was also no statistical difference between the interleukin-6 serum concentration at baseline (438±118 pg/ml), after nine sessions of control autohemotherapy (444±120 pg/ml), and after nine sessions of ozonated autohemotherapy (466±152 pg/ml).Conclusion: The results of this study suggest that ozonated autohemotherapy using an ozone concentration of 50 μg/ml does not induce an inflammatory response.

Systemic inflammatory response syndrome without systemic inflammation in acutely ill patients admitted to hospital in a medical emergency

1999 ◽  
Vol 96 (3) ◽  
pp. 287-295 ◽  
Author(s):  
Annika TAKALA ◽  
Irma JOUSELA ◽  
Klaus T. OLKKOLA ◽  
Sten-Erik JANSSON ◽  
Marjatta LEIRISALO-REPO ◽  
...  
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Systemic Inflammation ◽  
Interleukin 6 ◽  
Systemic Inflammatory Response ◽  
Composite Score ◽  
C Reactive Protein ◽  
Cd11b Expression ◽  
Reactive Protein ◽  
Markers Of Inflammation

Criteria of the systemic inflammatory response syndrome (SIRS) are known to include patients without systemic inflammation. Our aim was to explore additional markers of inflammation that would distinguish SIRS patients with systemic inflammation from patients without inflammation. The study included 100 acutely ill patients with SIRS. Peripheral blood neutrophil and monocyte CD11b expression, serum interleukin-6, interleukin-1β, tumour necrosis factor-α and C-reactive protein were determined, and severity of inflammation was evaluated by systemic inflammation composite score based on CD11b expression, C-reactive protein and cytokine levels. Levels of CD11b expression, C-reactive protein and interleukin-6 were higher in sepsis patients than in SIRS patients who met two criteria (SIRS2 group) or three criteria of SIRS (SIRS3 group). The systemic inflammation composite score of SIRS2 patients (median 1.5; range 0–8, n = 56) was lower than that of SIRS3 patients (3.5; range 0–9, n = 14, P = 0.013) and that of sepsis patients (5.0; range 3–10, n = 19, P< 0.001). The systemic inflammation composite score was 0 in 13/94 patients. In 81 patients in whom systemic inflammation composite scores exceeded 1, interleukin-6 was increased in 64 (79.0%), C-reactive protein in 59 (72.8%) and CD11b in 50 (61.7%). None of these markers, when used alone, identified all patients but at least one marker was positive in each patient. Quantifying phagocyte CD11b expression and serum interleukin-6 and C-reactive protein concurrently provides a means to discriminate SIRS patients with systemic inflammation from patients without systemic inflammation.

scholarly journals Relationship between the Plasma Concentration of C-Reactive Protein and Severity of Peripheral Arterial Disease

2009 ◽  
Vol 3 ◽  
pp. CMC.S1062 ◽  
Author(s):  
Joaquin De Haro ◽  
Francisco Acin ◽  
Francisco Jose Medina ◽  
Alfonso Lopez-Quintana ◽  
Jose Ramon March
Keyword(s):  
Peripheral Arterial Disease ◽  
Plasma Levels ◽  
Smoking Status ◽  
Arterial Disease ◽  
Clinical Severity ◽  
C Reactive Protein ◽  
Surgical Revascularization ◽  
Reactive Protein ◽  
Markers Of Inflammation ◽  
Peripheral Arterial

Objective To determine whether the increase in plasma levels of C-Reactive Protein (CRP), a non-specific reactant in the acute-phase of systemic inflammation, is associated with clinical severity of peripheral arterial disease (PAD). Methods and Results This is a cross-sectional study at a referral hospital center of institutional practice in Madrid, Spain. A stratified random sampling was done over a population of 3370 patients with symptomatic PAD from the outpatient vascular laboratory database in 2007 in the order of their clinical severity: the first group of patients with mild chronological clinical severity who did not require surgical revascularization, the second group consisted of patients with moderate clinical severity who had only undergone only one surgical revascularization procedure and the third group consisted of patients who were severely affected and had undergone two or more surgical revascularization procedures of the lower extremities in different areas or needed late re-interventions. The Neyman affixation was used to calculate the sample size with a fixed relative error of 0.1. A homogeneity analysis between groups and a unifactorial analysis of comparison of medians for CRP was done. The groups were homogeneous for age, smoking status, Arterial Hypertension HTA, diabetes mellitus, dyslipemia, homocysteinemia and specific markers of inflammation. In the unifactorial analysis of multiple comparisons of medians according to Scheffe, it was observed that the median values of CRP plasma levels were increased in association with higher clinical severity of PAD (3.81 mg/L [2.14-5.48] vs. 8.33 [4.38-9.19] vs. 12.83 [9.5-14.16]; p < 0.05) as a unique factor of tested ones. Conclusion Plasma levels of CRP are associated with not only the presence of atherosclerosis but also with its chronological clinical severity.

scholarly journals In Vivo Confirmation of the Role of Statins in Reducing Nitric Oxide and C-Reactive Protein Levels in Peripheral Arterial Disease

2009 ◽  
Vol 37 (4) ◽  
pp. 443-447 ◽  
Author(s):  
E. Martínez Aguilar ◽  
J. De Haro Miralles ◽  
A. Flórez González ◽  
C. Varela Casariego ◽  
S. Bleda Moreno ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Peripheral Arterial

Positive correlation of serum indoxyl sulfate level with peripheral arterial disease in hemodialysis patients

Vascular ◽  
2021 ◽  
pp. 170853812110399
Author(s):  
Liang-Te Chiu ◽  
Lin Lin ◽  
Huei-Jhen Lin ◽  
Yu-Hsien Lai ◽  
Bang-Gee Hsu
Keyword(s):  
Peripheral Arterial Disease ◽  
Ankle Brachial Index ◽  
Serum Levels ◽  
Arterial Disease ◽  
Indoxyl Sulfate ◽  
Maintenance Hemodialysis ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Index Group ◽  
Peripheral Arterial

Objectives Indoxyl sulfate, known for its cardiovascular toxicity, is associated with vascular and coronary artery diseases and increased mortality. Peripheral arterial disease, defined by low ankle–brachial index, is associated with increased mortality in patients on hemodialysis. The present study aimed to determine the relationship between the serum indoxyl sulfate level and peripheral arterial disease in patients on maintenance hemodialysis. Methods The present cross-sectional, single-center study included 75 patients on maintenance hemodialysis. Serum indoxyl sulfate levels were determined by high-performance liquid chromatography–mass spectrometry. Ankle–brachial index values were measured using an automated oscillometric device. Patients with ankle–brachial indexes of < 0.9 were categorized into the low ankle–brachial index group. Results In the study cohort, 12 of the 75 patients (16.0%) had low ankle–brachial indexes. The rates of diabetes mellitus ( p = 0.010) as well as the serum levels of C-reactive protein ( p < 0.001) and indoxyl sulfate ( p < 0.001) were higher in the low ankle–brachial index group than the normal ankle–brachial index group. The multivariable logistic regression analysis revealed that serum levels of indoxyl sulfate (odds ratio = 1.123, 95% confidence interval 1.011–1.249, p = 0.031) and C-reactive protein (each 0.1 mg/dL increase, odds ratio = 1.169, 95% confidence interval 1.018–1.343, p = 0.027) were independently associated with peripheral arterial disease in patients on maintenance hemodialysis. Conclusions Serum indoxyl sulfate levels were associated with peripheral arterial disease in patients on maintenance hemodialysis.

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