scholarly journals Relationship between the Plasma Concentration of C-Reactive Protein and Severity of Peripheral Arterial Disease

2009 ◽  
Vol 3 ◽  
pp. CMC.S1062 ◽  
Author(s):  
Joaquin De Haro ◽  
Francisco Acin ◽  
Francisco Jose Medina ◽  
Alfonso Lopez-Quintana ◽  
Jose Ramon March
Keyword(s):  
Peripheral Arterial Disease ◽  
Plasma Levels ◽  
Smoking Status ◽  
Arterial Disease ◽  
Clinical Severity ◽  
C Reactive Protein ◽  
Surgical Revascularization ◽  
Reactive Protein ◽  
Markers Of Inflammation ◽  
Peripheral Arterial

Objective To determine whether the increase in plasma levels of C-Reactive Protein (CRP), a non-specific reactant in the acute-phase of systemic inflammation, is associated with clinical severity of peripheral arterial disease (PAD). Methods and Results This is a cross-sectional study at a referral hospital center of institutional practice in Madrid, Spain. A stratified random sampling was done over a population of 3370 patients with symptomatic PAD from the outpatient vascular laboratory database in 2007 in the order of their clinical severity: the first group of patients with mild chronological clinical severity who did not require surgical revascularization, the second group consisted of patients with moderate clinical severity who had only undergone only one surgical revascularization procedure and the third group consisted of patients who were severely affected and had undergone two or more surgical revascularization procedures of the lower extremities in different areas or needed late re-interventions. The Neyman affixation was used to calculate the sample size with a fixed relative error of 0.1. A homogeneity analysis between groups and a unifactorial analysis of comparison of medians for CRP was done. The groups were homogeneous for age, smoking status, Arterial Hypertension HTA, diabetes mellitus, dyslipemia, homocysteinemia and specific markers of inflammation. In the unifactorial analysis of multiple comparisons of medians according to Scheffe, it was observed that the median values of CRP plasma levels were increased in association with higher clinical severity of PAD (3.81 mg/L [2.14-5.48] vs. 8.33 [4.38-9.19] vs. 12.83 [9.5-14.16]; p < 0.05) as a unique factor of tested ones. Conclusion Plasma levels of CRP are associated with not only the presence of atherosclerosis but also with its chronological clinical severity.

Positive correlation of serum indoxyl sulfate level with peripheral arterial disease in hemodialysis patients

Vascular ◽  
2021 ◽  
pp. 170853812110399
Author(s):  
Liang-Te Chiu ◽  
Lin Lin ◽  
Huei-Jhen Lin ◽  
Yu-Hsien Lai ◽  
Bang-Gee Hsu
Keyword(s):  
Peripheral Arterial Disease ◽  
Ankle Brachial Index ◽  
Serum Levels ◽  
Arterial Disease ◽  
Indoxyl Sulfate ◽  
Maintenance Hemodialysis ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Index Group ◽  
Peripheral Arterial

Objectives Indoxyl sulfate, known for its cardiovascular toxicity, is associated with vascular and coronary artery diseases and increased mortality. Peripheral arterial disease, defined by low ankle–brachial index, is associated with increased mortality in patients on hemodialysis. The present study aimed to determine the relationship between the serum indoxyl sulfate level and peripheral arterial disease in patients on maintenance hemodialysis. Methods The present cross-sectional, single-center study included 75 patients on maintenance hemodialysis. Serum indoxyl sulfate levels were determined by high-performance liquid chromatography–mass spectrometry. Ankle–brachial index values were measured using an automated oscillometric device. Patients with ankle–brachial indexes of < 0.9 were categorized into the low ankle–brachial index group. Results In the study cohort, 12 of the 75 patients (16.0%) had low ankle–brachial indexes. The rates of diabetes mellitus ( p = 0.010) as well as the serum levels of C-reactive protein ( p < 0.001) and indoxyl sulfate ( p < 0.001) were higher in the low ankle–brachial index group than the normal ankle–brachial index group. The multivariable logistic regression analysis revealed that serum levels of indoxyl sulfate (odds ratio = 1.123, 95% confidence interval 1.011–1.249, p = 0.031) and C-reactive protein (each 0.1 mg/dL increase, odds ratio = 1.169, 95% confidence interval 1.018–1.343, p = 0.027) were independently associated with peripheral arterial disease in patients on maintenance hemodialysis. Conclusions Serum indoxyl sulfate levels were associated with peripheral arterial disease in patients on maintenance hemodialysis.

scholarly journals C-Reactive Protein Predicts Progression of Peripheral Arterial Disease in Patients with Type 2 Diabetes: A 5-Year Follow-Up Study

2014 ◽  
Vol 33 (4) ◽  
pp. 347-355
Author(s):  
Ljiljana Popović ◽  
Katarina Lalić ◽  
Olga Vasović ◽  
Danijela Drašković Radojković ◽  
Nataša Rajković ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Group A ◽  
Hs Crp ◽  
Group B ◽  
Peripheral Arterial

Summary Background: Previous studies have indicated that high sensitivity C-reactive protein (hs-CRP) is a risk factor for the peripheral arterial disease (PAD) in diabetes. This study aimed to evaluate the possible predictive significance of hs-CRP for the development and progression of PAD in patients with type 2 diabetes (T2D). Methods: The study included 80 patients previously diagnosed with T2D, aged 45–70 years, divided into group A (T2D patients with PAD; n=38) and group B (T2D patients without PAD; n=42). After five years, all the patients were re-examined and divided into subgroups depending on de novo development of PAD or progression of previously diagnosed PAD. Ankle-Brachial Index (ABI) measurement was used for PAD diagnosis and hs-CRP was determined by nephelometry. Results: We found significantly higher hs-CRP levels in group A compared to group B, but only at baseline. Among the patients in group A, those with later progression of PAD (subgroup A1) had the highest levels of hs-CRP at baseline, although not significantly different from those in subgroup A2 (non-progressors). In contrast, hs-CRP level was significantly higher in subgroup B1 (progressors) in comparison to subgroup B2 (non-progressors) at both the first and second exam. Of all the investigated metabolic parameters, hs-CRP was the only independent predictor of PAD progression (OR=0.456, 95% CI=0.267–0.7815, p=0.004). The cut-off point for hs-CRP was 2.5 mg/L (specificity 75% and sensitivity 73.3%) with the relative risk for PAD of 2.93 (95% CI=1.351–6.3629). Conclusions: Our study implies that hs-CRP can be used as a reliable predictor for the progression of PAD in patients with T2D.

Assessment of the relation between C-reactive protein to albumin ratio and the severity and complexity of peripheral arterial disease

Vascular ◽  
2020 ◽  
Vol 28 (6) ◽  
pp. 731-738 ◽  
Author(s):  
Muhammed Süleymanoğlu ◽  
Cengiz Burak ◽  
Ayça Gümüşdağ ◽  
Mahmut Yesin ◽  
İbrahim Rencüzoğulları ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Disease Severity ◽  
Care Center ◽  
Characteristic Curve ◽  
Tertiary Care ◽  
Arterial Disease ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein ◽  
Peripheral Arterial

Background Peripheral arterial disease is associated with increased cardiovascular mortality and morbidity. C-reactive protein and albumin are biomarkers of inflammation and malnutrition that play key roles in the pathophysiological pathways involved in the progression of atherosclerosis and peripheral arterial disease. In this study, we aimed to assess the relationship between C-reactive protein to albumin ratio and the suprapopliteal peripheral arterial disease severity and complexity as assessed by TransAtlantic Inter-Society Consensus-II (TASC-II) classification. Method Our study enrolled 224 consecutive patients referred for peripheral angiography with the clinical features of possible peripheral arterial disease at a tertiary care center between January 2016 and September 2019. Level of disease and lesion characteristics were defined with reference to angiographic findings according to the TASC-II classification. Results C-reactive protein/albumin ratio levels were significantly higher in TASC-II class C and D than in TASC-II class B patients with a median level of 1.8 to 2.1 vs 1.4, respectively ( p = 0.018). In multivariate regression analysis, C-reactive protein to albumin ratio remained an independent predictor of severe peripheral arterial disease. The predictive performance of C-reactive protein to albumin ratio, C-reactive protein, and albumin were compared by Receiver Operating Characteristic curve analysis. C-reactive protein to albumin ratio surpassed C-reactive protein and albumin in predicting peripheral arterial disease severity and complexity. A level of C-reactive protein to albumin ratio  > 0.14 predicted a higher grade of suprapopliteal TASC-II class with sensitivity and specificity of 68.2% and 56.0%, respectively. Conclusion C-reactive protein to albumin ratio was strongly associated with peripheral arterial disease severity and complexity, as assessed by TASC-II classification. Also, C-reactive protein to albumin ratio was found to be a more accurate marker than C-reactive protein and albumin alone in predicting more severe and complex lesions in patients with peripheral arterial disease.

Role of C-Reactive Protein in Peripheral Arterial Disease

2018 ◽  
Vol 3 (12) ◽  
Author(s):  
Dr. Robert Skopec Ibaram
Keyword(s):  
Peripheral Arterial Disease ◽  
Strong Association ◽  
High Sensitivity ◽  
Arterial Disease ◽  
Online Search ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Peripheral Arterial

Objective: To review the role of elevated C - reactive protein (CRP) as a marker for predicting the development of Peripheral Arterial Disease (PAD). Methods: An online search was conducted using the most trusted medical data base PubMed and the articles published in peer-reviewed journals within the last 5 years (from the year 2005 to date) to collect evidence about the association of C-reactive protein with Peripheral Arterial Disease, using keywords like C-reactive protein, hs-C-reactive protein, inflammation, atherogenesis, peripheral arterial disease and their combinations. Out of 240 articles shown during online search on PubMed, only 17 articles related to the role of CRP and High sensitivity CRP (hs-CRP) as a marker in PAD. Results: 17 articles based on the role of CRP and High sensitivity CRP (hs-CRP) as a marker in PAD were studied and evaluated thoroughly working on their study design and outcomes. Almost all the 17 studies showed strong association hs-CRP with PAD. The results are described in the form of a table. Conclusion: CRP seems to be a marker of severity of PAD and it may serve as a strong prognostic indicator.

scholarly journals C-reactive protein as predictor of death in end-stage diabetic nephropathy: Role of peripheral arterial disease

2005 ◽  
Vol 68 (1) ◽  
pp. 217-227 ◽  
Author(s):  
Carsten A. Boger ◽  
Angela Gotz ◽  
Mike Stubanus ◽  
Bernhard Banas ◽  
Martina Deinzer ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Peripheral Arterial ◽  
End Stage
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