Positive correlation of serum indoxyl sulfate level with peripheral arterial disease in hemodialysis patients

Vascular ◽  
2021 ◽  
pp. 170853812110399
Author(s):  
Liang-Te Chiu ◽  
Lin Lin ◽  
Huei-Jhen Lin ◽  
Yu-Hsien Lai ◽  
Bang-Gee Hsu
Keyword(s):  
Peripheral Arterial Disease ◽  
Ankle Brachial Index ◽  
Serum Levels ◽  
Arterial Disease ◽  
Indoxyl Sulfate ◽  
Maintenance Hemodialysis ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Index Group ◽  
Peripheral Arterial

Objectives Indoxyl sulfate, known for its cardiovascular toxicity, is associated with vascular and coronary artery diseases and increased mortality. Peripheral arterial disease, defined by low ankle–brachial index, is associated with increased mortality in patients on hemodialysis. The present study aimed to determine the relationship between the serum indoxyl sulfate level and peripheral arterial disease in patients on maintenance hemodialysis. Methods The present cross-sectional, single-center study included 75 patients on maintenance hemodialysis. Serum indoxyl sulfate levels were determined by high-performance liquid chromatography–mass spectrometry. Ankle–brachial index values were measured using an automated oscillometric device. Patients with ankle–brachial indexes of < 0.9 were categorized into the low ankle–brachial index group. Results In the study cohort, 12 of the 75 patients (16.0%) had low ankle–brachial indexes. The rates of diabetes mellitus ( p = 0.010) as well as the serum levels of C-reactive protein ( p < 0.001) and indoxyl sulfate ( p < 0.001) were higher in the low ankle–brachial index group than the normal ankle–brachial index group. The multivariable logistic regression analysis revealed that serum levels of indoxyl sulfate (odds ratio = 1.123, 95% confidence interval 1.011–1.249, p = 0.031) and C-reactive protein (each 0.1 mg/dL increase, odds ratio = 1.169, 95% confidence interval 1.018–1.343, p = 0.027) were independently associated with peripheral arterial disease in patients on maintenance hemodialysis. Conclusions Serum indoxyl sulfate levels were associated with peripheral arterial disease in patients on maintenance hemodialysis.

scholarly journals Association between peripheral arterial disease and creactive protein in the japanese-brazilian population

2014 ◽  
Vol 41 (3) ◽  
pp. 168-175
Author(s):  
Luciana Garofolo ◽  
Sandra Roberta G. Ferreira ◽  
Fausto Miranda Júnior
Keyword(s):  
Peripheral Arterial Disease ◽  
Ankle Brachial Index ◽  
Arterial Disease ◽  
Population Based ◽  
Brazilian Population ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Study Results ◽  
Peripheral Arterial

OBJECTIVE: To evaluate the relationship between peripheral arterial disease and elevated levels of C-reactive protein in the Japanese-Brazilian population of high cardiovascular risk. METHODS: We conducted a cross-sectional study derived from a population-based study on the prevalence of diabetes and associated diseases in the Japanese-Brazilian population. One thousand, three hundred and thirty individuals aged e" 30 underwent clinical and laboratory examination, including measurement of ultrasensitive C-reactive protein. The diagnosis of peripheral arterial disease was performed by calculating the ankle-brachial index. We considered with peripheral arterial disease patients who had ankle-brachial index d" 0.9. After applying the exclusion criteria, 1,038 subjects completed the study. RESULTS: The mean age of the population was 56.8 years; 46% were male. The prevalence of peripheral arterial disease was 21%, with no difference between genders. Data analysis showed no association between peripheral arterial disease and ultrasensitive C-reactive protein. Patients with ankle-brachial index d" 0.70 showed higher values of ultrasensitive C-reactive protein and worse cardiometabolic profile. We found a positive independent association of peripheral arterial disease with hypertension and smoking. CONCLUSION: The association between low levels of ankle-brachial index and elevated levels of ultrasensitive C-reactive protein may suggest a relationship of gravity, aiding in the mapping of high-risk patients.

scholarly journals Use of rivaroxaban and acetylsalicylic acid as a combined treatment for peripheral arterial disease in Central Military Hospital

2020 ◽  
Vol 9 (1) ◽  
pp. 15
Author(s):  
Rigoberto Román-Hernández ◽  
Rodrigo Banegas-Ruiz ◽  
Claudia N. Jiménez-Nateras ◽  
Manuel Martínez-Meraz ◽  
Carmen G. Torres-Alarcón ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Acetylsalicylic Acid ◽  
Ankle Brachial Index ◽  
Peak Systolic Velocity ◽  
Arterial Disease ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Tibial Artery ◽  
Peripheral Arterial ◽  
Prospective Longitudinal

Background: The objective of this research was to evaluate the behavior of 3 risk indicators for peripheral arterial disease in patients under oral treatment with rivaroxaban 2.5 mg every 12 hours plus, acetylsalicylic acid 100 mg every 24 hours. It was hypothesized that the oral combination of rivaroxaban and acetylsalicylic acid presents a therapeutic advantage over other treatments.Methods: A prospective longitudinal and non-randomized study of a single center was performed. 59 patients with peripheral arterial disease were included and treated with acetylsalicylic acid + rivaroxaban. Peak systolic velocity, ankle-brachial index and C reactive protein index were evaluated.Results: Significant changes were found at month 1 and 3 of follow-up in maximum systolic velocity, ankle-arm index and C-reactive protein index. The baseline peak systolic velocity (PSV) in the anterior tibial artery had significant differences after one month of treatment (p=0.001) and after 3 months (p=0.001). The baseline PSV in the posterior tibial artery had significant differences compared to the values found at the month of treatment (p=0.001) and 3 months (p=0.001). In the ankle-brachial index a baseline median of 0.790 was found, one month after the treatment of 0.795 (p=0.147) and 3 months after 0.800 (p=0.019). The mean baseline C-reactive protein obtained was 73.142 mg/l, at one month 87.233 mg/l (p=0.001) and at 3 months at 79.009 mg/l (p=0.294) with a standard deviation of 67.18, 74.78 and 69.69 respectively.Conclusions: The combined use of acetylsalicylic acid and rivaroxaban allows a clinical improvement in patients with peripheral arterial disease.

scholarly journals C-Reactive Protein Predicts Progression of Peripheral Arterial Disease in Patients with Type 2 Diabetes: A 5-Year Follow-Up Study

2014 ◽  
Vol 33 (4) ◽  
pp. 347-355
Author(s):  
Ljiljana Popović ◽  
Katarina Lalić ◽  
Olga Vasović ◽  
Danijela Drašković Radojković ◽  
Nataša Rajković ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Group A ◽  
Hs Crp ◽  
Group B ◽  
Peripheral Arterial

Summary Background: Previous studies have indicated that high sensitivity C-reactive protein (hs-CRP) is a risk factor for the peripheral arterial disease (PAD) in diabetes. This study aimed to evaluate the possible predictive significance of hs-CRP for the development and progression of PAD in patients with type 2 diabetes (T2D). Methods: The study included 80 patients previously diagnosed with T2D, aged 45–70 years, divided into group A (T2D patients with PAD; n=38) and group B (T2D patients without PAD; n=42). After five years, all the patients were re-examined and divided into subgroups depending on de novo development of PAD or progression of previously diagnosed PAD. Ankle-Brachial Index (ABI) measurement was used for PAD diagnosis and hs-CRP was determined by nephelometry. Results: We found significantly higher hs-CRP levels in group A compared to group B, but only at baseline. Among the patients in group A, those with later progression of PAD (subgroup A1) had the highest levels of hs-CRP at baseline, although not significantly different from those in subgroup A2 (non-progressors). In contrast, hs-CRP level was significantly higher in subgroup B1 (progressors) in comparison to subgroup B2 (non-progressors) at both the first and second exam. Of all the investigated metabolic parameters, hs-CRP was the only independent predictor of PAD progression (OR=0.456, 95% CI=0.267–0.7815, p=0.004). The cut-off point for hs-CRP was 2.5 mg/L (specificity 75% and sensitivity 73.3%) with the relative risk for PAD of 2.93 (95% CI=1.351–6.3629). Conclusions: Our study implies that hs-CRP can be used as a reliable predictor for the progression of PAD in patients with T2D.

scholarly journals Vitamin D serum levels and peripheral arterial disease among southern Brazilian adults

2020 ◽  
Vol 66 (3) ◽  
pp. 268-274 ◽  
Author(s):  
Simone Bonatto ◽  
Vera Maria Vieira Paniz ◽  
Clandio de Freitas Dutra ◽  
Ruth Liane Henn
Keyword(s):  
Vitamin D ◽  
Serum Level ◽  
Peripheral Arterial Disease ◽  
Ankle Brachial Index ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Arterial Disease ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Peripheral Arterial

SUMMARY OBJECTIVE To investigate the association between low serum vitamin D levels and peripheral arterial disease (PAD). METHODS A cross-sectional study with a consecutive sample of 133 individuals from Caxias do Sul, Brasil. We considered PAD patients those with an ankle-brachial index (ABI) ≤ 0.90 or with arterial revascularization. Vitamin D serum level was categorized as sufficient (≥30 ng/mL), insufficient (>20 to 29 ng/mL), and deficient (<20 ng/mL). Prevalence ratios (RP) were calculated through Poisson regression. RESULTS The prevalence of PAD was 50.7% (95% CI 42-59). After adjustment for potential PAD risk factors, RP were 1.08 (95% CI 0.66-1.76) for insufficient serum level and 1.57 (95% CI 0.96-2.57) for deficient vitamin D serum level; (p for trend = 0.020). CONCLUSION Vitamin D serum levels showed an inverse and significant dose-response relationship with PAD.

Assessment of the relation between C-reactive protein to albumin ratio and the severity and complexity of peripheral arterial disease

Vascular ◽  
2020 ◽  
Vol 28 (6) ◽  
pp. 731-738 ◽  
Author(s):  
Muhammed Süleymanoğlu ◽  
Cengiz Burak ◽  
Ayça Gümüşdağ ◽  
Mahmut Yesin ◽  
İbrahim Rencüzoğulları ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Disease Severity ◽  
Care Center ◽  
Characteristic Curve ◽  
Tertiary Care ◽  
Arterial Disease ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein ◽  
Peripheral Arterial

Background Peripheral arterial disease is associated with increased cardiovascular mortality and morbidity. C-reactive protein and albumin are biomarkers of inflammation and malnutrition that play key roles in the pathophysiological pathways involved in the progression of atherosclerosis and peripheral arterial disease. In this study, we aimed to assess the relationship between C-reactive protein to albumin ratio and the suprapopliteal peripheral arterial disease severity and complexity as assessed by TransAtlantic Inter-Society Consensus-II (TASC-II) classification. Method Our study enrolled 224 consecutive patients referred for peripheral angiography with the clinical features of possible peripheral arterial disease at a tertiary care center between January 2016 and September 2019. Level of disease and lesion characteristics were defined with reference to angiographic findings according to the TASC-II classification. Results C-reactive protein/albumin ratio levels were significantly higher in TASC-II class C and D than in TASC-II class B patients with a median level of 1.8 to 2.1 vs 1.4, respectively ( p = 0.018). In multivariate regression analysis, C-reactive protein to albumin ratio remained an independent predictor of severe peripheral arterial disease. The predictive performance of C-reactive protein to albumin ratio, C-reactive protein, and albumin were compared by Receiver Operating Characteristic curve analysis. C-reactive protein to albumin ratio surpassed C-reactive protein and albumin in predicting peripheral arterial disease severity and complexity. A level of C-reactive protein to albumin ratio  > 0.14 predicted a higher grade of suprapopliteal TASC-II class with sensitivity and specificity of 68.2% and 56.0%, respectively. Conclusion C-reactive protein to albumin ratio was strongly associated with peripheral arterial disease severity and complexity, as assessed by TASC-II classification. Also, C-reactive protein to albumin ratio was found to be a more accurate marker than C-reactive protein and albumin alone in predicting more severe and complex lesions in patients with peripheral arterial disease.

Role of C-Reactive Protein in Peripheral Arterial Disease

2018 ◽  
Vol 3 (12) ◽  
Author(s):  
Dr. Robert Skopec Ibaram
Keyword(s):  
Peripheral Arterial Disease ◽  
Strong Association ◽  
High Sensitivity ◽  
Arterial Disease ◽  
Online Search ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Peripheral Arterial

Objective: To review the role of elevated C - reactive protein (CRP) as a marker for predicting the development of Peripheral Arterial Disease (PAD). Methods: An online search was conducted using the most trusted medical data base PubMed and the articles published in peer-reviewed journals within the last 5 years (from the year 2005 to date) to collect evidence about the association of C-reactive protein with Peripheral Arterial Disease, using keywords like C-reactive protein, hs-C-reactive protein, inflammation, atherogenesis, peripheral arterial disease and their combinations. Out of 240 articles shown during online search on PubMed, only 17 articles related to the role of CRP and High sensitivity CRP (hs-CRP) as a marker in PAD. Results: 17 articles based on the role of CRP and High sensitivity CRP (hs-CRP) as a marker in PAD were studied and evaluated thoroughly working on their study design and outcomes. Almost all the 17 studies showed strong association hs-CRP with PAD. The results are described in the form of a table. Conclusion: CRP seems to be a marker of severity of PAD and it may serve as a strong prognostic indicator.

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