Flavonoid glycosides from the fruits of Embelia ribes and their anti-oxidant and α-glucosidase inhibitory activities

2020 ◽  
pp. 1-7
Author(s):  
Yu Qin ◽  
Jin-Peng Chen ◽  
Chun-Yu Li ◽  
Ling-Juan Zhu ◽  
Xue Zhang ◽  
...  
Keyword(s):  
Flavonoid Glycosides ◽  
Embelia Ribes ◽  
Anti Oxidant ◽  
Inhibitory Activities

Anti-Oxidant and Inhibitory Activities on Elastase, Collagenase, Hyaluronidase, and α-Glucosidase of Cedrela sinensis Fruits

2018 ◽  
Vol 47 (11) ◽  
pp. 1085-1092 ◽  
Author(s):  
Su-Bin Lim ◽  
Myung-Uk Kim ◽  
Eun-Ho Lee ◽  
Ye-Jin Kim ◽  
Eun-Bi Cho ◽  
...  
Keyword(s):  
Anti Oxidant ◽  
Inhibitory Activities

scholarly journals Aspergiloid I, an unprecedented spirolactone norditerpenoid from the plant-derived endophytic fungus Aspergillus sp. YXf3

2014 ◽  
Vol 10 ◽  
pp. 2677-2682 ◽  
Author(s):  
Zhi Kai Guo ◽  
Rong Wang ◽  
Wei Huang ◽  
Xiao Nian Li ◽  
Rong Jiang ◽  
...  
Keyword(s):  
Endophytic Fungus ◽  
Spectroscopic Data ◽  
Biosynthetic Pathway ◽  
Culture Broth ◽  
Ring System ◽  
X Ray Diffraction ◽  
X Ray ◽  
Anti Oxidant ◽  
Inhibitory Activities ◽  
Aspergillus Sp

An unusual C18 norditerpenoid, aspergiloid I (1), was isolated from the culture broth of Aspergillus sp. YXf3, an endophytic fungus derived from Ginkgo biloba. Its structure was unambiguously established by analysis of HRMS–ESI and spectroscopic data, and the absolute configuration was determined by low-temperature (100 K) single crystal X-ray diffraction with Cu Kα radiation. This compound is structurally characterized by a new carbon skeleton with an unprecedented 6/5/6 tricyclic ring system bearing an α,β-unsaturated spirolactone moiety in ring B, and represents a new subclass of norditerpenoid, the skeleton of which is named aspergilane. The hypothetical biosynthetic pathway for 1 was also proposed. The cytotoxic, antimicrobial, anti-oxidant and enzyme inhibitory activities of 1 were evaluated.

scholarly journals Isolation of Isocoumarins and Flavonoids as α-Glucosidase Inhibitors from Agrimonia pilosa L.

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2572
Author(s):  
Mi Jin Park ◽  
Young-Hwa Kang
Keyword(s):  
Kinetic Analysis ◽  
Competitive Inhibition ◽  
Flavonoid Compound ◽  
Flavonoid Glycosides ◽  
Phytochemical Study ◽  
Glucosidase Inhibitors ◽  
Key Factor ◽  
Ic50 Values ◽  
Inhibitory Activities ◽  
First Time

Agrimonia pilosa L. (AP) showed potent α-glucosidase inhibitory (AGI) activity, but it is uncertain what phytochemicals play a key factor. The phytochemical study of AP based on AGI activity led to the isolation of four isocoumarins; agrimonolide (1), agrimonolide-6-O-β-d-glucopyranoside (2), desmethylagrimonolide (3), desmethylagrimonolide-6-O-β-d-glucopyranoside (4), and four flavonoids; luteolin (5), quercetin (6), vitexin (7), and isovitexin (8). The four isocoumarins were isolated as α-glucosidase inhibitors for the first time. Isocoumarins, compound 1 (agrimonolide) and 3 (desmethylagrimonolide) showed strong α-glucosidase inhibitory activities with IC50 values of 24.2 and 37.4 µM, respectively. Meanwhile, isocoumarin and flavonoid glycosides showed weak AGI activity. In the kinetic analysis, isocoumarins, compounds 1 and 3 showed non-competitive inhibition, whereas flavonoid, compound 6 showed competitive inhibition.

Concise synthesis and antidiabetic activity of natural flavonoid glycosides, oroxins C and D, isolated from the seeds of Oroxylum indium

2020 ◽  
pp. 174751982092796 ◽  
Author(s):  
Gang Li ◽  
Guanghui Wang ◽  
Yangliu Tong ◽  
Junheng Zhu ◽  
Tongtong Yun ◽  
...  
Keyword(s):  
Natural Products ◽  
Inhibitory Activity ◽  
Antidiabetic Activity ◽  
Flavonoid Glycosides ◽  
Strong Inhibition ◽  
Oroxylum Indicum ◽  
Inhibitory Activities ◽  
Lipase Inhibition

The first concise synthesis of natural flavonoid glycosides, oroxins C (1) and D (2), which were isolated from the seeds of Oroxylum indicum, was efficiently achieved by a convergent strategy. The synthesized natural products 1 and 2 were evaluated for their inhibitory activities against α-glucosidase, α-amylase, and lipase. Compound 1 showed strong α-amylase and lipase inhibition, with IC50 values of 210 and 190 μM, respectively, but exhibited no inhibitory activity against α-glucosidase. Compound 2 showed strong inhibition against α-glucosidase and lipase, with the respective IC50 values of 180 and 80 μM.

Isolation of Flavonoids and Flavonoid Glycosides from Myrsine africana and Their Inhibitory Activities against Mushroom Tyrosinase

2018 ◽  
Vol 81 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Navneet Kishore ◽  
Danielle Twilley ◽  
Analike Blom van Staden ◽  
Praveen Verma ◽  
Bikram Singh ◽  
...  
Keyword(s):  
Flavonoid Glycosides ◽  
Mushroom Tyrosinase ◽  
Inhibitory Activities ◽  
Myrsine Africana

scholarly journals Evaluation of the Antihyperuricemic Activity of Phytochemicals fromDavallia formosanaby Enzyme Assay and Hyperuricemic Mice Model

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Chen-Yu Chen ◽  
Chi-Chang Huang ◽  
Keng-Chang Tsai ◽  
Wei-Jan Huang ◽  
Wen-Ching Huang ◽  
...  
Keyword(s):  
Uric Acid ◽  
Enzyme Assay ◽  
Critical Factor ◽  
Serum Urate ◽  
Flavonoid Glycosides ◽  
Mice Model ◽  
Inhibitory Activities ◽  
Potassium Oxonate

Abnormal serum urate levels are recognized as a critical factor in the progression of several chronic diseases. To evaluate the antihyperuricemic effect ofDavallia formosana, the inhibitory activities of 15 isolated phytochemicals, including five novel compounds of 6,8-dihydroxychromone-7-C-β-d-glucopyranoside (1), 6,8,3′,4′-tetrahydroxyflavanone-7-C-β-d-glucopyranoside (2), 6,8,4′-trihydroxyflavanone-7-C-β-d-glucopyranoside (3), 8-(2-pyrrolidinone-5-yl)-catechin-3-O-β-d-allopyranoside (4), and epiphyllocoumarin-3-O-β-d-allopyranoside (5), were examined against xanthine oxidase (XOD) and in a potassium oxonate-(PTO-) induced acute hyperuricemic mice model. The results indicated that compounds3and5significantly inhibited XOD activityin vitroand reduced serum uric acid levelsin vivo. This is the first report providing new insights into the antihyperuricemic activities of flavonoid glycosides which can possibly be developed into potential hypouricemic agents.

Flavonoid Glycosides fromAdina racemosaand Their Inhibitory Activities on Eukaryotic Protein Synthesis

2004 ◽  
Vol 67 (3) ◽  
pp. 427-431 ◽  
Author(s):  
Atsuko Itoh ◽  
Takao Tanahashi ◽  
Naotaka Nagakura ◽  
Yukiko Takenaka ◽  
Cheng-Chang Chen ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Flavonoid Glycosides ◽  
Eukaryotic Protein ◽  
Inhibitory Activities
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