Synthesis of Functionalized-Magnetic Nanoparticles and Application as a Retrievable and Efficient Catalyst for the Green Synthesis of Pyrano[2,3-c]Phenazine-15-yl)Methanone Derivatives Under Solvent-Free Conditions

Author(s):  
Milad Taheri ◽  
Razieh Mohebat ◽  
Mohammad Hossein Moslemin
RSC Advances ◽  
2016 ◽  
Vol 6 (64) ◽  
pp. 59343-59351 ◽  
Author(s):  
M. Afradi ◽  
N. Foroughifar ◽  
H. Pasdar ◽  
H. Moghanian

Synthesis, characterization and utilization of the l-proline N-sulfonic acid-functionalized magnetic nanoparticles as a novel magnetically reusable acid catalyst for the synthesis of 3,4-dihydropyrimidine-2-[1H]thione derivatives is reported.


Synlett ◽  
2017 ◽  
Vol 29 (04) ◽  
pp. 493-496 ◽  
Author(s):  
Fatemeh Sheikholeslami-Farahani ◽  
Maryam Ghazvini ◽  
Somayeh Soleimani-Amiri ◽  
Masoomeh Salimifard ◽  
Rezvaneh Rostamian

Pyrido[2,1-a]isoquinoline and pyrido[1,2-a]quinoline derivatives have been produced in good yields by the reaction of isoquinoline or quinoline, activated acetylenic compounds, α-halo ketones, and triphenylphosphine in the presence of ZnO nanoparticles (NPs) as an efficient catalyst under solvent-free conditions at room temperature. The reaction workup is easy, and the products can be readily separated from the reaction mixture. ZnO NPs markedly improved the yield of the product. The catalyst showed significant reusable activity.


2016 ◽  
Vol 18 (9) ◽  
pp. 2843-2850 ◽  
Author(s):  
Pallab Kumar Saikia ◽  
Podma Pollov Sarmah ◽  
Bibek Jyoti Borah ◽  
Lakshi Saikia ◽  
Kokil Saikia ◽  
...  

Fe3O4@AT-mont. based on naturally occurring montmorillonite exhibit an efficient catalytic Baeyer–Villiger oxidation for different cyclic and aromatic ketones.


2014 ◽  
Vol 68 (8) ◽  
Author(s):  
Cheng-Liang Feng ◽  
Ning-Ning Chu ◽  
Shu-Guang Zhang ◽  
Jin Cai ◽  
Jun-Qing Chen ◽  
...  

AbstractA novel application of highly stable Fe(OTf)3 as an efficient catalyst for the synthesis of a variety of β-enamino ketones and esters under solvent-free conditions is described. Notably, this protocol of a “green synthesis”, which produced β-enamino ketones and esters by the reaction of a variety of β-dicarbonyl compounds and primary amines, exhibits attractive properties including high yields, short reaction periods, lower loading of catalyst and chemo- and regio-selectivity. In addition, the catalyst was easily recovered from the reaction system and readily reused with minimal loss of activity.


2018 ◽  
Vol 21 (8) ◽  
pp. 602-608 ◽  
Author(s):  
Zainab Ehsani-Nasab ◽  
Ali Ezabadi

Aim and Objective: In the present work, 1, 1’-sulfinyldiethylammonium bis (hydrogen sulfate) as a novel room temperature dicationic ionic liquid was synthesized and used as a catalyst for xanthenediones synthesis. Material and Method: The dicationic ionic liquid has been synthesized using ethylamine and thionyl chloride as precursors. Then, by the reaction of [(EtNH2)2SO]Cl2 with H2SO4, [(EtNH2)2SO][HSO4]2 was prepared and after that, it was characterized by FT-IR, 1H NMR, 13C NMR as well as Hammett acidity function. This dicationic ionic liquid was used as a catalyst for the synthesis of xanthenediones via condensation of structurally diverse aldehydes and dimedone under solvent-free conditions. The progress of the reaction was monitored by thin layer chromatography (ethyl acetate/n-hexane = 3/7). Results: An efficient solvent-free method for the synthesis of xanthenediones has been developed in the presence of [(EtNH2)2SO][HSO4]2 as a powerful catalyst with high to excellent yields, and short reaction times. Additionally, recycling studies have demonstrated that the dicationic ionic liquid can be readily recovered and reused at least four times without significant loss of its catalytic activity. Conclusion: This new dicationic ionic liquid can act as a highly efficient catalyst for xanthenediones synthesis under solvent-free conditions.


2019 ◽  
Vol 16 (5) ◽  
pp. 776-786 ◽  
Author(s):  
Deepa ◽  
Geeta D. Yadav ◽  
Mohd J. Aalam ◽  
Pooja Chaudhary ◽  
Surendra Singh

Objective:DABCO salts were evaluated as catalysts for the Biginelli reaction between 4- methoxybenzaldehyde, urea and ethyl acetoacetate under solvent-free conditions. 1,4-Diazabicyclo [2.2.2] octane triflate was found to be a simple, inexpensive, highly efficient catalyst for Biginelli reaction for a variety aromatic aldehyde with urea and ethyl acetoacetate at 80°C afforded corresponding 3,4-dihydropyrimidinones in 50-99% yields after 30-120 minutes. 1,3-Cyclohexadione was used in place of ethyl acetoacetate in the absence of urea this methodology is giving hexahydro xanthene derivatives in good to excellent yields after 3-4 hours.Methods:DABCO salt 4 (5 mol%), 4-methoxybenzaldehyde (0.73 mmol) and urea (0.73 mmol) were stirred for 10 minutes at 80°C, then ethyl acetoacetate (1.5 equiv.) was added and reaction mixture was stirred at 80°C for specified time. The resulting solution was stirred continuously and progress of the reaction was followed by TLC. The crude reaction mixture was purified by flash column chromatography on silica gel (hexane/ethyl acetate (1:2)) to give pure desired product.Results:Reaction conditions of the Biginelli reaction were optimized using 4-methoxybenzaldehyde (0.73 mmol), urea (0.73 mmol), and ethyl acetoacetate (5 equiv.) as model substrates catalyzed by 1,4-Diazabicyclo [2.2.2] octane triflate (5 mol%) in a different solvents, screening of different catalysts and different temperatures. Neat condition was found to be the best for the Biginelli condensation and corresponding 3,4- dihydropyrimidinones was obtained in good to excellent yields. When the reaction was carried out with benzaldehyde derivatives and cyclohexane-1,3-dione in place of ethyl acetoacetate in the absence of urea, solely corresponding hexahydro xanthene derivatives were obtained in 61-91% yields.Conclusion:In conclusion, we have applied salts of 1,4-Diaza-bicyclo [2.2.2] octane as catalysts in the Biginelli condensation and corresponding 3,4-dihydropyrimidinones were obtained in 50- 99% yields under solvent free conditions. This methodology is having advantages like simple work-up; low loading of catalyst and reaction was performed at moderate temperature under solvent-free conditions.


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