Ketene dithioacetal mediated synthesis of 1,3,4,5-tetrasubstituted pyrazole derivatives and their biological evaluation

2019 ◽  
Vol 194 (8) ◽  
pp. 843-849 ◽  
Author(s):  
Pravin S. Bhale ◽  
Babasaheb P. Bandgar ◽  
Sakharam B. Dongare ◽  
Sadanand N. Shringare ◽  
Dnyaneshwar M. Sirsat ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Pyrazole Derivatives ◽  
Ketene Dithioacetal

Microwave assisted synthesis of novel Pyrazole derivatives and their biological evaluation as anti-bacterial agents

2020 ◽  
Vol 23 ◽  
Author(s):  
Hadis Khodadad ◽  
Farhad Hatamjafari ◽  
Khalil Pourshamsian ◽  
Babak Sadeghi
Keyword(s):  
Antibacterial Activity ◽  
Aromatic Aldehydes ◽  
Catalytic Amount ◽  
Antibacterial Activities ◽  
Structural Features ◽  
Biological Evaluation ◽  
Aureus Strain ◽  
Microwave Assisted Synthesis ◽  
Pyrazole Derivatives ◽  
Microwave Assisted

Aim and Objective: Microwave-assisted condensation of acetophenone 1 and aromatic aldehydes 2 gave chalcone analogs 3, which were cyclized to pyrazole derivatives 6a-f via the reaction with hydrazine hydrate and oxalic acid in the presence of the catalytic amount of acetic acid in ethanol. Materials and Methods: The structural features of the synthesized compounds were characterized by melting point, FT-IR, 1H, 13C NMR and elemental analysis. Results: The antibacterial activities of the synthesized pyrazoles was evaluated against three gram-positive bacteria such as Enterococcus durans, Staphylococcus aureus, Bacillus subtilis and two gram-negative bacteria such as Escherichia coli and Salmonella typhimurium. Conclusion: All the synthesized pyrazoles showed relatively high antibacterial activity against S. aureus strain and none of them demonstrated antibacterial activity against E. coli.

Design, synthesis and biological evaluation of novel 5-phenyl-1H-pyrazole derivatives as potential BRAFV600E inhibitors

2014 ◽  
Vol 22 (21) ◽  
pp. 6201-6208 ◽  
Author(s):  
Shu-Fu Wang ◽  
Yin-Ling Zhu ◽  
Ping-Ting Zhu ◽  
Jigar A. Makawana ◽  
Ya-Liang Zhang ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Pyrazole Derivatives ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis, Characterization and Biological Evaluation of Some New Oxino bis-Pyrazole Derivatives

2016 ◽  
Vol 28 (8) ◽  
pp. 1648-1652
Author(s):  
Abdul Ghafoor ◽  
Noreen Aslam ◽  
Mark C. Elliott ◽  
Naveed Sajid ◽  
Muhammad Nasrullah ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Pyrazole Derivatives
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