Sample Size and Power Estimation in Thorough QT/QTc Studies with Parallel Group Design

2010 ◽  
Vol 20 (3) ◽  
pp. 595-603 ◽  
Author(s):  
Balakrishna Hosmane ◽  
Charles Locke ◽  
Yi-Lin Chiu
Keyword(s):  
Sample Size ◽  
Power Estimation ◽  
Group Design ◽  
Parallel Group Design ◽  
Parallel Group

A Clinical Study of Quazepam in Hospitalized Patients with Insomnia

1981 ◽  
Vol 9 (4) ◽  
pp. 288-291 ◽  
Author(s):  
Hans K Uhthoff ◽  
Jacques A Brunet ◽  
Anand Aggerwal ◽  
Raymond Varin
Keyword(s):  
Clinical Study ◽  
Sleep Quality ◽  
Quality Index ◽  
Adverse Reactions ◽  
Activity Index ◽  
Global Evaluation ◽  
Group Design ◽  
Parallel Group Design ◽  
Parallel Group ◽  
Hypnotic Activity

The efficacy of quazepam (Sch-16134) 15 mg capsules as a hypnotic has been compared with that of placebo in a 9-day study, using a parallel-group design. The physician's global evaluation numerically favoured quazepam 63% (nineteen of thirty) over placebo 50% (fifteen of thirty). Furthermore, it demonstrated greater improvement in Hypnotic Activity Index and Sleep Quality Index from baseline scores, and caused no adverse reactions.

scholarly journals Improving Attitudes to Volunteering Among Older Adults: A Randomized Trial Approach

2019 ◽  
Vol 42 (2) ◽  
pp. 51-61 ◽  
Author(s):  
Michelle I. Jongenelis ◽  
Ben Jackson ◽  
Jeni Warburton ◽  
Robert U. Newton ◽  
Simone Pettigrew
Keyword(s):  
Older Adults ◽  
Social Connectedness ◽  
Healthy Aging ◽  
Social Needs ◽  
Volunteer Work ◽  
Group Design ◽  
Perceptions And Attitudes ◽  
Parallel Group Design ◽  
Parallel Group ◽  
Negative Perceptions

Promoting engagement in formal volunteering represents a potential means of facilitating healthy aging. Given reluctance to participate in volunteering has been partially attributed to negative perceptions of various aspects of this activity, this study assessed whether trialing volunteering can improve perceptions among older people. Using a parallel-group design, Australians aged 60+ years ( n = 445) were randomly assigned to one of two conditions, one in which they were encouraged to trial volunteering and one in which they were asked to continue their usual activities. Perceptions and attitudes among those in the volunteering condition became significantly more favorable over 6 months relative to those in the control condition, with this change predicted by several aspects of the volunteering experience (e.g., acquisition of skills, increased social connectedness). Providing access to roles that cater to the learning and social needs of older adults appears to be important for improving attitudes toward engaging in volunteer work.

scholarly journals Perbedaan aromatherapi lavender dan lemon untuk menurunkan mual muntah ibu hamil

2020 ◽  
Vol 15 (2) ◽  
Author(s):  
Sarwinanti Sarwinanti ◽  
Nur Aini Istiqomah
Keyword(s):  
T Test ◽  
Group Design ◽  
Parallel Group Design ◽  
Parallel Group

Aromaterapi merupakan terapi komplementer yang dapat diberikan oleh perawat secara mandiri. Aromaterapi lavender dapat mengatasi mual muntah karena mengandung linalool dan linalyl asetat yang memberikan efek nyaman, tenang dan relaks. Aromaterapi lemon dapat mengatasi mual muntah karena mengandung limonene. Penelitian ini bertujuan untuk mengetahui perbedaan pemberian aromaterapi lavender dengan aromaterapi lemon terhadap kejadian mual muntah ibu hamil trimester I. Metode penelitian menggunakan quasy experiment with parallel group design. Responden penelitian ini adalah ibu hamil trimester I berjumlah 32 orang. Analisa data menggunakan uji t-test dependent. Hasil penelitian menunjukkan bahwa aromaterapi lemon lebih efektif menurunkan mual muntah ibu hamil trimester I.

scholarly journals A National Quality Improvement Collaborative for the clinical use of outcome measurement in specialised mental healthcare: Results from a parallel group design and a nested cluster randomised controlled trial

BJPsych Open ◽  
2017 ◽  
Vol 3 (3) ◽  
pp. 106-112 ◽  
Author(s):  
Margot J. Metz ◽  
Marjolein A. Veerbeek ◽  
Gerdien C. Franx ◽  
Christina M. van der Feltz-Cornelis ◽  
Edwin de Beurs ◽  
...  
Keyword(s):  
Outcome Measurement ◽  
Controlled Trial ◽  
Mental Healthcare ◽  
Cluster Randomised Controlled Trial ◽  
Group Design ◽  
Cluster Randomised ◽  
Parallel Group Design ◽  
Parallel Group ◽  
National Quality ◽  
Randomised Controlled

BackgroundAlthough the importance and advantages of measurement-based care in mental healthcare are well established, implementation in daily practice is complex and far from optimal.AimsTo accelerate the implementation of outcome measurement in routine clinical practice, a government-sponsored National Quality Improvement Collaborative was initiated in Dutch-specialised mental healthcare.MethodTo investigate the effects of this initiative, we combined a matched-pair parallel group design (21 teams) with a cluster randomised controlled trial (RCT) (6 teams). At the beginning and end, the primary outcome ‘actual use and perceived clinical utility of outcome measurement’ was assessed.ResultsIn both designs, intervention teams demonstrated a significant higher level of implementation of outcome measurement than control teams. Overall effects were large (parallel group d=0.99; RCT d=1.25).ConclusionsThe National Collaborative successfully improved the use of outcome measurement in routine clinical practice.

scholarly journals Eight Weeks ofCosmos caudatus(Ulam Raja) Supplementation Improves Glycemic Status in Patients with Type 2 Diabetes: A Randomized Controlled Trial

2015 ◽  
Vol 2015 ◽  
pp. 1-7
Author(s):  
Shi-Hui Cheng ◽  
Amin Ismail ◽  
Joseph Anthony ◽  
Ooi Chuan Ng ◽  
Azizah Abdul Hamid ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Randomized Controlled Trial ◽  
Serum Insulin ◽  
Controlled Trial ◽  
Glycemic Status ◽  
Group Design ◽  
Randomized Controlled ◽  
Parallel Group Design ◽  
Parallel Group

Objectives. Optimizing glycemic control is crucial to prevent type 2 diabetes related complications.Cosmos caudatusis reported to have promising effect in improving plasma blood glucose in an animal model. However, its impact on human remains ambiguous. This study was carried out to evaluate the effectiveness ofC. caudatuson glycemic status in patients with type 2 diabetes.Materials and Methods. In this randomized controlled trial with two-arm parallel-group design, a total of 101 subjects with type 2 diabetes were randomly allocated to diabetic-ulam or diabetic controls for eight weeks. Subjects in diabetic-ulam group consumed 15 g ofC. caudatusdaily for eight weeks while diabetic controls abstained from takingC. caudatus.Both groups received the standard lifestyle advice.Results. After 8 weeks of supplementation,C. caudatussignificantly reduced serum insulin (−1.16 versus +3.91), reduced HOMA-IR (−1.09 versus +1.34), and increased QUICKI (+0.05 versus −0.03) in diabetic-ulam group compared with the diabetic controls. HbA1C level was improved although it is not statistically significant (−0.76% versus −0.37%).C. caudatuswas safe to consume.Conclusions.C. caudatussupplementation significantly improves insulin resistance and insulin sensitivity in patients with type 2 diabetes.

A Comparison of Paroxetine, Imipramine and Placebo in Depressed Out-patients

1991 ◽  
Vol 159 (3) ◽  
pp. 394-398 ◽  
Author(s):  
G. C. Dunbar ◽  
J. B. Cohn ◽  
L. F. Fabre ◽  
J. P. Feighner ◽  
R. R. Fieve ◽  
...  
Keyword(s):  
Side Effects ◽  
Beneficial Effect ◽  
Anxiety Symptoms ◽  
Drop Out ◽  
Antidepressant Effect ◽  
Double Blind ◽  
Group Design ◽  
Parallel Group Design ◽  
Parallel Group ◽  
Antidepressant Efficacy

To compare the safety and antidepressant efficacy of paroxetine, imipramine, and placebo, data from six centres using the same protocol were pooled. A double-blind parallel-group design was used, with therapy lasting six weeks. From week 2 onwards, both the 240 paroxetine-treated and the 237 imipramine-treated patients were significantly different from the 240 placebo-treated patients, but no different from each other. Side-effects with paroxetine were less likely to lead to drop-out than with imipramine. Paroxetine had a possible earlier antidepressant effect than imipramine, and a possible earlier beneficial effect on anxiety symptoms associated with depression.

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