Preparation, characterization, and antibacterial properties of biocompatible material for wound healing

Wound healing is a perfectly coordinated cascade of cellular, molecular, and biochemical events which interact in tissue reconstitution. Chronic diseases such as pressure ulcers (PU) and diabetes mellitus (DM) are considered risk factors for wound healing. Patients with such diseases often have higher sepsis, infection, and complication rates, since they have revascularization inhibition and low growth factor expression. Thus, latex biomembrane (LBM), a biocompatible material, derived from the latex of the rubber tree (Hevea brasiliensis) appears to create tendencies as an angiogenic-inducing tissue healing agent and as biomaterial, resulting from its structural qualities and its low cost when compared to conventional treatments. Therefore, this work aims at summarizing the results, experiments, and scientific findings that certify or recommend the use of LBM as a new technique to be applied effectively in the treatment of wounds. An integrative review was held in the BIREME, LILACS, Burns, MEDLINE, PubMed, and SciELO databases, from 2000 to 2016, using the following descriptors: “healing,” “diabetes mellitus,” “wounds,” and “latex membrane.” As a result, 600 experiments (out of 612) presented satisfactory results; however, 33% of the cases received explicit recommendations, 11% required more studies on the subjects, and 1% was denied. On the other hand, half of the studies did not expressly endorse its use, despite presenting satisfactory results. The LBM was characterized as a good therapeutic alternative in cases of wounds, including chronic diseases, such as diabetes mellitus and PU, due to its relevant potential for wound healing stimulation, acceleration of cell tissue mending and revascularization, or the reestablishment of angiogenic functions (creation of new blood vessels). The LBM was also confirmed to be safe as a biocompatible material whose structural qualities (elasticity, adaptability, impermeability, and possibility of suture), devoid of toxicity, allowed interaction between tissues and presented no hypersensitivity inducer and no antimicrobial effect.

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Novel chitosan hydrogels reinforced by silver nanoparticles with ultrahigh mechanical and high antibacterial properties for accelerating wound healing

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2018.07.060 ◽

2018 ◽

Vol 119 ◽

pp. 402-412 ◽

Cited By ~ 42

Author(s):

Yajuan Xie ◽

Xiaozhu Liao ◽

Jingxiang Zhang ◽

Feiwen Yang ◽

Zengjie Fan

Keyword(s):

Wound Healing ◽

Silver Nanoparticles ◽

Antibacterial Properties ◽

Chitosan Hydrogels

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Water absorbing and antibacterial properties ofN-isopropyl acrylamide grafted and collagen/chitosan immobilized polypropylene nonwoven fabric and its application on wound healing enhancement

Journal of Biomedical Materials Research Part A ◽

10.1002/jbm.a.31482 ◽

2008 ◽

Vol 84A (4) ◽

pp. 1006-1017 ◽

Cited By ~ 52

Author(s):

Chyung-Chyung Wang ◽

Ching-Hua Su ◽

Cheng-Chi Chen

Keyword(s):

Wound Healing ◽

Antibacterial Properties ◽

Nonwoven Fabric ◽

Isopropyl Acrylamide

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Preparation and in vitro osteogenic, angiogenic and antibacterial properties of cuprorivaite (CaCuSi4O10, Cup) bioceramics

RSC Advances ◽

10.1039/c6ra08145b ◽

2016 ◽

Vol 6 (51) ◽

pp. 45840-45849 ◽

Cited By ~ 25

Author(s):

Tian Tian ◽

Chengtie Wu ◽

Jiang Chang

Keyword(s):

Wound Healing ◽

Sol Gel ◽

Antibacterial Properties ◽

Antibacterial Activities ◽

Gel Method ◽

Sol Gel Method

Cuprorivaite firstly synthesized by sol–gel method with angiogenic and antibacterial activities for wound healing application.

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Effect of Carica papaya Extract toward Incised Wound Healing Process in Mice (Mus musculus) Clinically and Histologically

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2019/8306519 ◽

2019 ◽

Vol 2019 ◽

pp. 1-5

Author(s):

Rachmi Fanani Hakim ◽

Fakhrurrazi ◽

Dinni

Keyword(s):

Wound Healing ◽

Mus Musculus ◽

Carica Papaya ◽

Healing Process ◽

Antibacterial Properties ◽

The Body ◽

Wound Healing Process ◽

Protective Function ◽

Incised Wound ◽

Anterior Teeth

Wound healing entails a sequence of complex biological processes, which is a protective function of the body that focuses on a quick recovery. Reducing wound healing time is crucial in a wound as it lowers the chance of infection and decreases complications and costs. Papaya extract was obtained by a maceration method. It contains papain enzyme, flavonoid, saponin, and alkaloid, which act as an anti-inflammatory, astringent substance, vasodilator, antioxidant, analgesic, with antifungal, and antibacterial properties, and increase the collagen synthesis. This study aimed to assess the effect of Carica papaya extract application toward incised wound healing process in mice (Mus musculus) clinically and histologically. This experimental laboratory study was performed using 24 mice weighing between 30 and 40 grams and 12 and 14 weeks of age as experimental animals. Each group was incised along 5 mm at the labial gingiva under both of mandible anterior teeth with a depth reaching alveolar bone. Papaya extract was applied topically in the morning and evening for 14 days. The clinical result was obtained by assessing the length of wound closure measured every day for 14 days. Based on the statistic test result, it showed that the papaya extract has a significant effect (p≤0.05) toward the healing process of an incised oral wound in mice. Histologically at day 14, 75% concentration papaya extract showed perfect epithelial layer and fibrillation.

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Correction: Ga and Ce ion-doped phosphate glass fibres with antibacterial properties and their composite for wound healing applications

Journal of Materials Chemistry B ◽

10.1039/c9tb90158b ◽

2019 ◽

Vol 7 (45) ◽

pp. 7246-7246

Author(s):

Agata Łapa ◽

Mark Cresswell ◽

Ian Campbell ◽

Phil Jackson ◽

Wolfgang H. Goldmann ◽

...

Keyword(s):

Wound Healing ◽

Phosphate Glass ◽

Antibacterial Properties ◽

Glass Fibres

Correction for ‘Ga and Ce ion-doped phosphate glass fibres with antibacterial properties and their composite for wound healing applications’ by Agata Łapa et al., J. Mater. Chem. B, 2019, DOI: 10.1039/c9tb00820a.

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Antibacterial-Integrated Collagen Wound Dressing for Diabetes-Related Foot Ulcers: An Evidence-Based Review of Clinical Studies

Polymers ◽

10.3390/polym12092168 ◽

2020 ◽

Vol 12 (9) ◽

pp. 2168

Author(s):

Ibrahim N. Amirrah ◽

Mohd Farhanulhakim Mohd Razip Wee ◽

Yasuhiko Tabata ◽

Ruszymah Bt Hj Idrus ◽

Abid Nordin ◽

...

Keyword(s):

Wound Healing ◽

Clinical Trials ◽

Clinical Studies ◽

Wound Dressing ◽

Chronic Wounds ◽

Gentian Violet ◽

Antibacterial Properties ◽

Small Sample ◽

Wound Dressings ◽

Sample Sizes

Diabetic foot ulcer (DFU) is a chronic wound frequently delayed from severe infection. Wound dressing provides an essential barrier between the ulcer and the external environment. This review aimed to analyse the effectiveness of antibacterial collagen-based dressing for DFU treatment in a clinical setting. An electronic search in four databases, namely, Scopus, PubMed, Ovid MEDLINE(R), and ISI Web of Science, was performed to obtain relevant articles published within the last ten years. The published studies were included if they reported evidence of (1) collagen-based antibacterial dressing or (2) wound healing for diabetic ulcers, and (3) were written in English. Both randomised and non-randomised clinical trials were included. The search for relevant clinical studies (n) identified eight related references discussing the effectiveness of collagen-based antibacterial wound dressings for DFU comprising collagen impregnated with polyhexamethylene biguanide (n = 2), gentamicin (n = 3), combined-cellulose and silver (n = 1), gentian violet/methylene blue mixed (n = 1), and silver (n = 1). The clinical data were limited by small sample sizes and multiple aetiologies of chronic wounds. The evidence was not robust enough for a conclusive statement, although most of the studies reported positive outcomes for the use of collagen dressings loaded with antibacterial properties for DFU wound healing. This study emphasises the importance of having standardised clinical trials, larger sample sizes, and accurate reporting for reliable statistical evidence confirming DFU treatment efficiency.

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