Exploring the beneficial effects and possible mechanisms of repeated episodes of whole-body hypoxic perconditioning in rat model of preeclampsia

2020 ◽  
Vol 39 (3) ◽  
pp. 267-282
Author(s):  
Yan Li ◽  
Chunyun Wang ◽  
Jing Wang ◽  
Leisi Tao
Keyword(s):  
Rat Model ◽  
Whole Body ◽  
Beneficial Effects

Uric acid improves the beneficial effects of rt-PA in a rat model of thromboembolic ischemia

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S129-S129
Author(s):  
Eduardo Romanos ◽  
Anna M Planas ◽  
Angel Chamorro
Keyword(s):  
Uric Acid ◽  
Rat Model ◽  
Beneficial Effects

scholarly journals A rat model of organophosphate-induced status epilepticus and the beneficial effects of EP2 receptor inhibition

2020 ◽  
Vol 133 ◽  
pp. 104399 ◽  
Author(s):  
Asheebo Rojas ◽  
Thota Ganesh ◽  
Wenyi Wang ◽  
Jennifer Wang ◽  
Raymond Dingledine
Keyword(s):  
Status Epilepticus ◽  
Rat Model ◽  
Beneficial Effects ◽  
Receptor Inhibition ◽  
Ep2 Receptor

scholarly journals A Collagen-Based Scaffold for Promoting Neural Plasticity in a Rat Model of Spinal Cord Injury

Polymers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2245
Author(s):  
Jue-Zong Yeh ◽  
Ding-Han Wang ◽  
Juin-Hong Cherng ◽  
Yi-Wen Wang ◽  
Gang-Yi Fan ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Rat Model ◽  
Neural Plasticity ◽  
Collagen Scaffold ◽  
Glial Scar ◽  
Beneficial Effects ◽  
Cord Injury

In spinal cord injury (SCI) therapy, glial scarring formed by activated astrocytes is a primary problem that needs to be solved to enhance axonal regeneration. In this study, we developed and used a collagen scaffold for glial scar replacement to create an appropriate environment in an SCI rat model and determined whether neural plasticity can be manipulated using this approach. We used four experimental groups, as follows: SCI-collagen scaffold, SCI control, normal spinal cord-collagen scaffold, and normal control. The collagen scaffold showed excellent in vitro and in vivo biocompatibility. Immunofluorescence staining revealed increased expression of neurofilament and fibronectin and reduced expression of glial fibrillary acidic protein and anti-chondroitin sulfate in the collagen scaffold-treated SCI rats at 1 and 4 weeks post-implantation compared with that in untreated SCI control. This indicates that the collagen scaffold implantation promoted neuronal survival and axonal growth within the injured site and prevented glial scar formation by controlling astrocyte production for their normal functioning. Our study highlights the feasibility of using the collagen scaffold in SCI repair. The collagen scaffold was found to exert beneficial effects on neuronal activity and may help in manipulating synaptic plasticity, implying its great potential for clinical application in SCI.

BENEFICIAL EFFECTS OF GPI 6150, AN INHIBITOR OF POLY(ADP-RIBOSE) POLYMERASE IN A RAT MODEL OF SPLANCHNIC ARTERY OCCLUSION AND REPERFUSION.

Shock ◽  
2001 ◽  
Vol 15 (Supplement) ◽  
pp. 58-59
Author(s):  
E. Mazzon ◽  
L. Dugo ◽  
A. De Sarro ◽  
J. Li ◽  
A. P. Caputi ◽  
...  
Keyword(s):  
Rat Model ◽  
Artery Occlusion ◽  
Beneficial Effects ◽  
Splanchnic Artery

Discovery of Serum Proteomic Biomarkers for Prediction of Response to Moxibustion Treatment in Rats with Collagen-Induced Arthritis: An Exploratory Analysis

2016 ◽  
Vol 34 (3) ◽  
pp. 184-193 ◽  
Author(s):  
Xiao Xu ◽  
Miao-Miao Wang ◽  
Zhi-ling Sun ◽  
Dan-ping Zhou ◽  
Ling Wang ◽  
...  
Keyword(s):  
Rat Model ◽  
Multiple Testing ◽  
Day Treatment ◽  
Expression Patterns ◽  
Control Group ◽  
Sprague Dawley ◽  
Collagen Induced Arthritis ◽  
Serum Samples ◽  
Beneficial Effects ◽  
Bovine Collagen

Objective To examine the possible impact of moxibustion on the serum proteome of the collagen-induced arthritis (CIA) rat model. Materials and Methods Thirty-six male Sprague-Dawley rats were included in this experiment. The CIA animal model was prepared by injection of type II bovine collagen in Freund's adjuvant on the first and seventh day. The 36 rats were randomly divided into two groups: the untreated CIA group (control), and the CIA plus treatment with moxibustion (CIA+moxi) group. Moxibustion was administered daily at ST36 and BL23 for 7, 14 or 21 days (n=12 rats each). Arthritis score was used to assess the severity of arthritis. At the end of each 7 day treatment, blood samples from the control group and the CIA+moxi group were collected. After removal of high abundance proteins from serum samples, two-dimensional gel combined with matrix-assisted laser desorption ionisation time-of-flight MS/MS (MALDI-TOF-MS/MS) techniques were performed to examine serum protein expression patterns of the CIA rat model with and without moxibustion treatment. In addition, the relevant proteins were further analysed with the use of bioinformatics analysis. Results Moxibustion significantly decreased arthritis severity in the rats in the CIA+moxi group, when compared with the rats in the CIA group 35 days after the first immunisation (p=0.001). Seventeen protein spots which changed >1.33 or <0.77 at p<0.05 using Bonferonni correction for multiple testing were found to be common to all three comparisons, and these proteins were used for classification of functions using the Gene Ontology method. Consequently, with the use of the Ingenuity Pathway Analysis, the top canonical pathways and a predicted proteomic network related to the moxibustion effect of CIA were established. Conclusions Using the proteomics technique, we have identified novel candidate proteins that may be involved in the mechanisms of action underlying the beneficial effects of moxibustion in rats with CIA. Our findings suggest that immune responses and metabolic processes may be involved in mediating the effects of moxibustion. Moreover, periodxiredoxin I (PRDX1) and inositol 1,4,5-triphosphate receptor (IP3R) may be potential targets.

scholarly journals Beneficial effects of head-elevation during Controlled Automated Reperfusion of the WhoLe Body (CARL) in the pig model

Resuscitation ◽  
2018 ◽  
Vol 130 ◽  
pp. e35
Author(s):  
Domagoj Damjanovic ◽  
Joerg Haberstroh ◽  
Katharina Foerster ◽  
Martin Wolkewitz ◽  
Itumeleng Taunyane ◽  
...  
Keyword(s):  
Pig Model ◽  
Whole Body ◽  
Beneficial Effects ◽  
Head Elevation

scholarly journals Impact of dietary vitamin D3 supplements in nursery diets on subsequent growth and bone responses of pigs during an immune challenge

2019 ◽  
Vol 97 (12) ◽  
pp. 4895-4903 ◽  
Author(s):  
Morgan McCue ◽  
Jamie L Reichert ◽  
Thomas D Crenshaw
Keyword(s):  
Vitamin D3 ◽  
Growing Pigs ◽  
Whole Body ◽  
Dietary Vitamin ◽  
Vitamin D Metabolites ◽  
Immune Challenge ◽  
Subsequent Growth ◽  
Limited Evidence ◽  
Beneficial Effects ◽  
Nutrient Supplements

Abstract Limited evidence is available to validate beneficial responses from extra nutrient supplements for mediation of growth suppression that results from immune challenges. Extrarenal roles of vitamin D metabolites in immune function implicate vitamin D3 supplements as a nutrient for potential beneficial effects. The current objective was to assess growth and bone ash responses to dietary vitamin D3 (D) supplements for growing pigs undergoing an immune challenge. At weaning, 216 crossbred pigs (4 pigs/pen, 6 pens/treatment) were randomly allotted within sex and weight blocks to 1 of the 9 treatments. Treatments included D supplements (0, 100, or 800 IU/kg) in a factorial arrangement with 3 vaccine (V) protocols; no injection (0 × V), a single 2 mL injection of a Lawsonia intracellularis vaccine at day 14 (1 × V), or 2 mL injections of the same vaccine at days 0 and 7 (2 × V). An adjustment diet with no supplemental D was fed for 1 wk, then assigned D diets for 2 wk (P2). After P2, all pigs were phase-fed standard diets (D = 280 IU/kg) to assess subsequent growth to 115 kg. No differences due to D supplements or vaccination protocol were detected in ADG (0.233 ± 0.021 kg/d) or GF (0.642 ± 0.028 kg/d) over the 21-d nursery trial; however, ADFI was lower (P &lt; 0.10) in pigs fed D levels of 0 vs. 100 and 800 (0.340 vs. 0.375, 0.372 ± 0.027 kg/d). Bone mineral content (g) from whole-body dual energy X-ray absorptiometry scans at 9 wk (n = 4 pigs/treatment) was lower in pigs fed 0 vs. 100 and 800 IU of D (287 vs. 325, 323 ± 34.1 g/pig). Growth from nursery to 115 kg was lower (P &lt; 0.01) in pigs fed D levels of 0 vs.100 and 800 (0.828 vs. 0.876, 0.889 ± 0.021 kg/d). At market, approximately two-thirds of pigs showed positive L. intracellularis serology titers regardless of treatment. Limited evidence for D-mediation of an immune challenge using the vaccination protocols may be a consequence of limited vaccine effects on growth in the nursery and seroconversion of most pigs to L. intracellularis by market.

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