Background: Cognitive impairment is very common in patients with
hypertension, it’s necessary to conduct a meta-analysis to evaluate the
association of cognitive function and blood pressure variability in
patients with hypertension, to provide insights into the clinical
management of hypertension and cognitive impairment. Methods: We
searched PubMed et al databases for the case-control studies on the
association between blood pressure variability and cognitive function up
to July 15, 2021. Two researchers independently screened the literature
and retrieved the data. RevMan 5.3 was used for data meta-analysis
Results: A total of 13 studies involving 2754 patients were included.
Meta-analysis indicated that 24-hour systolic [MD= 3.54, 95% CI
(2.48, 4.60)] and diastolic [MD=2.43, 95%CI (1.55, 3.31)] blood
pressure variation coefficient in the CI group were significantly higher
than that of no CI group (all P<0.05). Standard deviation of
systolic [MD=2.20, 95% CI (0.27, 4.13)] and diastolic [MD=1.79,
95% CI (0.80, 2.79)] blood pressure variation in the CI group were
significantly higher than that of no CI group (all P<0.05).
Mean systolic [MD=3.73, 95% CI (0.92, 6.53)]and diastolic [MD =
5.41, 95% CI (0.42, 10.40)] blood pressure variation in the CI group
were significantly higher than that of no CI group (all
P<0.05). There were no statistically significant differences
in the morning peak systolic [MD=7.85,95% CI (-1.30,17.01)] and
diastolic [MD=4.44,95% CI (-6.00, 14.89)] blood pressure drop
between the CI group and no CI group(all P>0.05).
Conclusion: Cognitive impairment in hypertensive patients is closely
associated with increased blood pressure variability, and clinical
medical staff should pay attention to the management of blood pressure
variability in hypertensive patients to reduce the development of
cognitive impairments.
Meta-based association of the lipoprotein lipase gene S447X variant with hypertension and blood pressure variation
