Electrospun orally disintegrating film formulation of telmisartan

2021 ◽  
pp. 1-12
Author(s):  
Mehmet Birer ◽  
Füsun Acartürk
Keyword(s):  
Film Formulation

Development of an easily swallowed film formulation

2008 ◽  
Vol 355 (1-2) ◽  
pp. 62-66 ◽  
Author(s):  
Hideaki Okabe ◽  
Eiji Suzuki ◽  
Yusaku Sugiura ◽  
Kaisuke Yanagimoto ◽  
Yasunari Takanashi ◽  
...  
Keyword(s):  
Film Formulation

scholarly journals Design Optimization and In Vitro-In Vivo Evaluation of Orally Dissolving Strips of Clobazam

2014 ◽  
Vol 2014 ◽  
pp. 1-15 ◽  
Author(s):  
Rajni Bala ◽  
Sushil Khanna ◽  
Pravin Pawar
Keyword(s):  
Tensile Strength ◽  
Drug Release ◽  
Content Uniformity ◽  
In Vivo Evaluation ◽  
Disintegration Time ◽  
Significant Difference ◽  
Film Formulation ◽  
Test Film

Clobazam orally dissolving strips were prepared by solvent casting method. A full 32 factorial design was applied for optimization using different concentration of film forming polymer and disintegrating agent as independent variable and disintegration time, % cumulative drug release, and tensile strength as dependent variable. In addition the prepared films were also evaluated for surface pH, folding endurance, and content uniformity. The optimized film formulation showing the maximum in vitro drug release, satisfactory in vitro disintegration time, and tensile strength was selected for bioavailability study and compared with a reference marketed product (frisium5 tablets) in rabbits. Formulation (F6) was selected by the Design-expert software which exhibited DT (24 sec), TS (2.85 N/cm2), and in vitro drug release (96.6%). Statistical evaluation revealed no significant difference between the bioavailability parameters of the test film (F6) and the reference product. The mean ratio values (test/reference) of Cmax (95.87%), tmax (71.42%), AUC0−t (98.125%), and AUC0−∞ (99.213%) indicated that the two formulae exhibited comparable plasma level-time profiles.

scholarly journals DESIGN, CHARACTERIZATION AND STATISTICAL OPTIMIZATION OF RAMOSETRON HYDROCHLORIDE MOUTH DISSOLVING FILM USING DESIGN OF EXPERIMENT

2019 ◽  
pp. 224-230
Author(s):  
SUWARNA SURESH BOBDE ◽  
HEMRAJ M. TANK
Keyword(s):  
Tensile Strength ◽  
Drug Release ◽  
Cancer Patients ◽  
Nausea And Vomiting ◽  
Disintegration Time ◽  
Percent Elongation ◽  
Casting Technique ◽  
Factor Design ◽  
Film Formulation ◽  
Formulation Variables

Objective: The present study aims to prepare a mouth dissolving film of ramosetron hydrochloride to provide relief to cancer patients suffering from nausea and vomiting. Methods: Mouth dissolving film of ramosetron hydrochloride were prepared and optimized using three levels two factor design. The films were prepared using the solvent casting technique. The effect of formulation variables such as the concentration of HPMC E15, and honey on disintegration time, tensile strength and drug release from the film were studied. The films were evaluated for weight, thickness, folding endurance, tensile strength, percent elongation, surface pH, disintegration time and drug release. Results: All the films were found to be transparent, non-sticky and easily peelable. The concentration of HPMC E 15 and Honey was found to have a significant effect on disintegration time and drug release of the mouth dissolving film. Formulation R1 was found to the best formulation with 104.21 % release in 9 min and disintegration time of 57 seconds. Conclusion: It can be concluded that the developed mouth dissolving film could serve as an effective, convenient alternative to prevent nausea and vomiting in cancer patients of any age group.

scholarly journals Pharmaceutical and Pharmacokinetic Evaluation of a Novel Fast Dissolving Film Formulation of Flupentixol Dihydrochloride

2014 ◽  
Vol 15 (6) ◽  
pp. 1603-1610 ◽  
Author(s):  
Ahmed Abdelbary ◽  
Ehab R. Bendas ◽  
Afaf A. Ramadan ◽  
Dalia A. Mostafa
Keyword(s):  
Film Formulation ◽  
Pharmacokinetic Evaluation

scholarly journals Budesonide-Cyclodextrin in Hydrogel System: Impact of Quaternary Surfactant on in vitro-in vivo Assessment of Mucosal Drug Delivery

2020 ◽  
Vol 71 (6) ◽  
pp. 332-345
Author(s):  
Sunil Pattanaik ◽  
Souvik Nandi ◽  
Rudra Narayana Sahoo ◽  
Ashirbad Nanda ◽  
Rakesh Swain ◽  
...  
Keyword(s):  
Residence Time ◽  
Acute Inflammation ◽  
In Vitro Dissolution ◽  
Rabbit Eye ◽  
Film Formulation ◽  
Mucosal Drug Delivery ◽  
Hydroxypropyl Beta Cyclodextrin ◽  
Pass Metabolism

Budesonide, a glucocorticosteroid is generally used to treat chronic inflammation and asthma. Hepatic first-pass metabolism and poor solubility are the major causes of its limited oral bioavailability. Present work was undertaken for the preparation of hydrogel film formulation with cyclodextrin complexation of budesonide containing quaternary surfactant for possible enhancement of mucosal permeation. FTIR study confirmed drug-polymer hydrogen bonding. Almost complete amorphization of the drug was pronounced by SEM, DSC and XRD studies. The film containing benzalkonium and hydroxypropyl beta-cyclodextrin exhibited in vitro dissolution and mucosal permeation to the highest extent of 87.2 and 95.8 % respectively in contrast to the others. Film formed hydrogel in aqueous mucin and enhanced the mucosal tissue residence time due to the mucoadhesive nature of the polymer. Acute inflammation in the rabbit eye was controlled within 3 h by applying the film in the cul-de-sac. The presence of cyclodextrin and quaternary surfactant brought about significantly improved drug release and mucosal permeation compared to their absence in the HPMC film. Hydrogel formed in aqueous mucin enhanced the mucosal residence time and controlled acute inflammation in the rabbit eye within 3 h after topical application.

scholarly journals Buprenorphine buccal film for chronic pain management

2020 ◽  
Vol 10 (4) ◽  
pp. 213-223 ◽  
Author(s):  
Martin Hale ◽  
Joseph Gimbel ◽  
Richard Rauck
Keyword(s):  
Chronic Pain ◽  
Pain Relief ◽  
Review Article ◽  
Chronic Pain Management ◽  
First Line ◽  
Safety And Efficacy ◽  
Safety Risks ◽  
Pharmacokinetic Properties ◽  
Film Formulation ◽  
Effective Analgesia

Buprenorphine is a Schedule III opioid with unique pharmacodynamic and pharmacokinetic properties that contribute to effective analgesia and fewer safety risks than other opioids. This review article focuses on the buccal film formulation, which is preferable to other buprenorphine formulations on the basis of bioavailability, safety and efficacy. The clinical studies reviewed here confirm that buprenorphine buccal film offers effective and continuous pain relief that is generally well tolerated, with no cases of respiratory depression reported in any of the studies. On the basis of these clinical data and individual patient risk/benefit assessments, clinicians should consider utilizing buprenorphine buccal film as a first-line opioid treatment for chronic pain over other buprenorphine formulations or other opioids.

scholarly journals Intensification of Dihydroxybenzenes Degradation over Immobilized TiO2 Based Photocatalysts under Simulated Solar Light

2020 ◽  
Vol 10 (21) ◽  
pp. 7571
Author(s):  
Szymon Malinowski ◽  
Ivana Presečki ◽  
Igor Jajčinović ◽  
Ivan Brnardić ◽  
Vilko Mandić ◽  
...  
Keyword(s):  
Large Scale ◽  
Kinetic Modelling ◽  
Tubular Reactor ◽  
Reactor Design ◽  
Pilot Scale ◽  
Pure Tio2 ◽  
Simulated Solar Light ◽  
Film Formulation ◽  
Parabolic Collector ◽  
Photocatalytic Films

The work is focused on the assessment of possible methods for intensification of photocatalytic degradation of common water borne pollutants. Solar photocatalysis poses certain limitations for large scale application with several possible reactor designs which have shown an optimal performance. In the current study, a comparison between two types of pilot scale reactors was made: a flat-plate cascade reactor (FPCR) and tubular reactor with a compound parabolic collector (CPC). Apart from the reactor design, another aspect of possible intensification was a photocatalyst formulation. The efficiency of photocatalytic films that consisted of pure TiO2 nanoparticles was compared to the efficiency of films that consisted of TiO2/CNT composites. Intensification assessment was performed via detailed kinetic modelling, combining the optical properties of films, irradiation conditions and reactor mass balance. Intensification was expressed via intensification indices. Results showed the advantage of the CPC-based reactor design and an unbiased effect of sensitizing agent (CNT) in the photocatalytic film formulation.

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