Investigational therapies targeting CD3 for prevention and treatment of type 1 diabetes

Author(s):  
Carmen Mignogna ◽  
Ernesto Maddaloni ◽  
Luca D’Onofrio ◽  
Raffaella Buzzetti
Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1782
Author(s):  
Monika Grabia ◽  
Renata Markiewicz-Żukowska ◽  
Katarzyna Socha

Overweight and obesity are an increasingly common problem, not only among the healthy population, but also in adolescents with type 1 diabetes (T1DM). Excess body weight is related to many cardiometabolic complications as well as a high risk of metabolic syndrome (MetS). The purpose of this systematic review is to provide a concise and critical overview of the prevalence of MetS in children and adolescents with T1DM and, ultimately, to discuss prevention and treatment options. The study was conducted in accordance with PRISMA guidelines. This review shows that, apart from the growing percentage of overweight and obese children and adolescents with T1DM (on average 20.1% and 9.5%, respectively), the problem of the increasing incidence of MetS (range from 3.2 to 29.9%, depending on the criteria used) is one of the most important phenomena of our time. One of the methods of prevention and treatment is a combined approach: changing eating habits and lifestyle, but there are also reports about the beneficial effects of the gut microflora.


2012 ◽  
Vol 19 (3) ◽  
pp. 323-329
Author(s):  
Gabriela Florina Dale ◽  
Loredana Popa ◽  
Amorin Popa

Abstract The hypothesis that under some circumstances enteroviral infections can lead to type1 diabetes (T1D) was proposed several decades ago, based initially on evidence fromanimal studies and sero-epidemiology. The mechanisms leading to the diseaseinvolve complex interactions between the virus, host target tissue (pancreas) and theimmune system. The following article is intended as a review of several recentinformation of the topic based on human studies that try to establish a connectionbetween a viral infection and Type 1 diabetes. Through understanding better thisassociation and it’s implications in the onset of T1D potential new ways ofprevention and treatment may emerge.


Diabetologia ◽  
2011 ◽  
Vol 54 (5) ◽  
pp. 1136-1146 ◽  
Author(s):  
S.-M. Lee ◽  
H. Yang ◽  
D. M. Tartar ◽  
B. Gao ◽  
X. Luo ◽  
...  

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 125-LB
Author(s):  
SHAHNAWAZ IMAM ◽  
PERVAIZ DAR ◽  
MARIA A. ALFONSO-JAUME ◽  
JUAN C. JAUME

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