Stereotactic vs open biopsy for non-palpable breast lesions. Their impact on short term quality of life

Introduction: The social aspect of breast cancer presents a serious problem all the time. Quality of women´s life after surgery must be compared to life before it. Breast cancer treatments today are likely to cause less physical deformity from surgery than two decades ago but are more complex and extend over a longer period of time. Non-palpable breast lesions are findings with non-biologically specified importance, which can be responsible for development of cancer. The authors present the diagnosis and the results of the treatment of patients with non-palpable breast lesions. They were hospitalized at the Department of Surgery in Nitra from Jan uary 2014 untilJuly 2017 and we used the SNOLLmethod or wire guided excision under ultrasound control or digital stereotaxic. Results: From January 2014 until July 2017 there were 122 patients diagnosed with non-palpable breast lesions at the Department of Surgery at our hospital. 76 (62.3%) of these patients were diagnosed with carcinoma. Wire Guided Localization was performed in 99 (81.1%) patients; sentinel node was found in 41 (33.6%) patients using the SNOLL method. From all the patients a reoperation was conducted in 4 cases (3.3%) for close or positive margin status and in 3 cases (2.5%) for false negative perioperative sentinel biopsy. Conclusion: The technique combining 99mTc-MAA (albuminmacro aggregate marked by 99Technecium) and nanocoloid is a reliable localization method for non-palpable lesions and sentinel nodes. SNOLL is a practical and oncological safe technique of excision of a subclinical lesion in combination with sentinel biopsy. This technique brings new visions for the future, especially for quality of life after surgery, changes in body image and sexuality.

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Diagnosing non-palpable breast disease: short-term impact on quality of life of large-core needle biopsy versus open breast biopsy

Surgical Oncology ◽

10.1016/s0960-7404(02)00021-x ◽

2002 ◽

Vol 10 (4) ◽

pp. 177-181 ◽

Cited By ~ 23

Author(s):

H.M Verkooijen ◽

E Buskens ◽

P.H.M Peeters ◽

I.H.M Borel Rinkes ◽

H.J de Koning ◽

...

Keyword(s):

Quality Of Life ◽

Core Needle Biopsy ◽

Needle Biopsy ◽

Breast Biopsy ◽

Breast Disease ◽

Large Core ◽

Short Term ◽

Core Needle ◽

Palpable Breast

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198: Prospective Evaluation of Short-Term Impact and Recovery of Health-Related Quality of Life (HRQOL) in men Undergoing Radical Prostatectomy (RP)

The Journal of Urology ◽

10.1016/s0022-5347(18)34463-x ◽

2005 ◽

Vol 173 (4S) ◽

pp. 54-54

Author(s):

J. Slade Hubbard ◽

Aubrey Evans ◽

Culley C. Carson ◽

Eric Wallen ◽

Raj S. Pruthi

Keyword(s):

Quality Of Life ◽

Radical Prostatectomy ◽

Prospective Evaluation ◽

Health Related Quality ◽

Short Term ◽

Related Quality ◽

Health Related

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Cathartic Effect of Suicide Attempts Not Limited to Depression

Crisis ◽

10.1027//0227-5910.24.2.73 ◽

2003 ◽

Vol 24 (2) ◽

pp. 73-78 ◽

Cited By ~ 21

Author(s):

Yves Sarfati ◽

Blandine Bouchaud ◽

Marie-Christine Hardy-Baylé

Keyword(s):

Quality Of Life ◽

Depressive Symptoms ◽

Personality Traits ◽

Rating Scales ◽

Suicide Attempts ◽

World Health ◽

Life Questionnaire ◽

Short Term

Summary: The cathartic effect of suicide is traditionally defined as the existence of a rapid, significant, and spontaneous decrease in the depressive symptoms of suicide attempters after the act. This study was designed to investigate short-term variations, following a suicide attempt by self-poisoning, of a number of other variables identified as suicidal risk factors: hopelessness, impulsivity, personality traits, and quality of life. Patients hospitalized less than 24 hours after a deliberate (moderate) overdose were presented with the Montgomery-Asberg Depression and Impulsivity Rating Scales, Hopelessness scale, MMPI and World Health Organization's Quality of Life questionnaire (abbreviated versions). They were also asked to complete the same scales and questionnaires 8 days after discharge. The study involved 39 patients, the average interval between initial and follow-up assessment being 13.5 days. All the scores improved significantly, with the exception of quality of life and three out of the eight personality traits. This finding emphasizes the fact that improvement is not limited to depressive symptoms and enables us to identify the relative importance of each studied variable as a risk factor for attempted suicide. The limitations of the study are discussed as well as in particular the nongeneralizability of the sample and setting.

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On Being Precarious

Irish University Review ◽

10.3366/iur.2020.0433 ◽

2020 ◽

Vol 50 (1) ◽

pp. 51-54

Author(s):

Deirdre Flynn

Keyword(s):

Quality Of Life ◽

Short Term ◽

Teaching Research ◽

Part Time

In this essay, I reflect on my experience of part-time, fixed term, zero-hour, short-term, and unpaid contracts in academia. Precarious contracts are one of the biggest challenges facing our industry as neo-liberal values rule our institutions, impacting our teaching, research, and quality of life.

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Bioactive Peptides Sensitize Cells to Anticancer Effects of Oxaliplatin in Human Colorectal Cancer Xenografts in Nude Mice

Protein and Peptide Letters ◽

10.2174/0929866526666190405124955 ◽

2019 ◽

Vol 26 (7) ◽

pp. 512-522

Author(s):

Xian Li ◽

Long Xia ◽

Xiaohui Ouyang ◽

Qimuge Suyila ◽

Liya Su ◽

...

Keyword(s):

Quality Of Life ◽

Colorectal Cancer ◽

Nude Mice ◽

Low Dose ◽

Bioactive Peptides ◽

Human Colorectal Cancer ◽

Short Term ◽

Hct 116

Background: Despite new agent development and short-term benefits in patients with Colorectal Cancer (CRC), metastatic CRC cure rates have not improved due to high rates of oxaliplatin resistance and toxicity. There is an urgent need for effective tools to prevent and treat CRC and reduce morbidity and mortality of CRC patients. Exploring the effects of bioactive peptides on the antitumor to CRC was of vital importance to the clinical application. Objective: This study aimed to investigate the therapeutic impact of Anticancer Bioactive Peptides (ACBP) on anticancer effect of oxaliplatin (LOHP) in human colorectal cancer xenografts models in nude mice. Methods: HCT-116 cells were cultured in vitro via CCK-8 assays and the absorbance was measured at 450 nm. Apoptosis and cell cycle were assessed by Flow Cytometry (FCM) in vitro. HCT-116 human colorectal cancer cells inoculated subcutaneously in nude mice of treatment with PBS (GG), ACBP, LOHP, ACBP+LOHP (A+L) in vivo. The quality of life was assessed by dietary amount of nude mice, the weight of nude mice, inhibition rates, tumor weight and tumor volume. Immunohistochemistry and RT-qPCR method was conducted to determine the levels of apoptosisregulating proteins/genes in transplanted tumors. Results: ACBP induced substantial reductions in viable cell numbers and apoptosis of HCT116 cells in combined with LOHP in vitro. Compared with the control GG group, ACBP combined low dose oxaliplatin (U) group demonstrated significantly different tumor volume, the rate of apoptosis, the expression levels of Cyt-C, caspase-3,8,9 proteins and corresponding RNAs (P<0.05). The expression of pro-apoptotic proteins in the cytoplasm around the nucleus was significantly enhanced by ACBP. Short term intermittent use of ACBP alone indicted a certain inhibitory effect on tumor growth, and improve the quality of life of tumor bearing nude mice. Conclusion: ACBP significantly increased the anti-cancer responses of low dose oxaliplatin (L-LOHP), thus, significantly improving the quality of life of tumor-bearing nude mice.

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