Functional connectivity between the left and right inferior frontal lobes in a small sample of children with and without reading difficulties

Neurocase ◽  
2011 ◽  
Vol 17 (5) ◽  
pp. 425-439 ◽  
Author(s):  
Emily A. Farris ◽  
Timothy N. Odegard ◽  
Haylie L. Miller ◽  
Jeremiah Ring ◽  
Greg Allen ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Reading Difficulties ◽  
Frontal Lobes ◽  
Small Sample ◽  
Left And Right

scholarly journals Effect of corpus callosum agenesis on the language network in children and adolescents

2021 ◽  
Author(s):  
Lisa Bartha-Doering ◽  
Ernst Schwartz ◽  
Kathrin Kollndorfer ◽  
Florian Ph. S. Fischmeister ◽  
Astrid Novak ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Corpus Callosum ◽  
Network Connectivity ◽  
Functional Language ◽  
Healthy Controls ◽  
Language Abilities ◽  
Verbal Abilities ◽  
Left And Right ◽  
Language Network

AbstractThe present study is interested in the role of the corpus callosum in the development of the language network. We, therefore, investigated language abilities and the language network using task-based fMRI in three cases of complete agenesis of the corpus callosum (ACC), three cases of partial ACC and six controls. Although the children with complete ACC revealed impaired functions in specific language domains, no child with partial ACC showed a test score below average. As a group, ACC children performed significantly worse than healthy controls in verbal fluency and naming. Furthermore, whole-brain ROI-to-ROI connectivity analyses revealed reduced intrahemispheric and right intrahemispheric functional connectivity in ACC patients as compared to controls. In addition, stronger functional connectivity between left and right temporal areas was associated with better language abilities in the ACC group. In healthy controls, no association between language abilities and connectivity was found. Our results show that ACC is associated not only with less interhemispheric, but also with less right intrahemispheric language network connectivity in line with reduced verbal abilities. The present study, thus, supports the excitatory role of the corpus callosum in functional language network connectivity and language abilities.

scholarly journals A Connectome-Wide Functional Signature of Trait Anger

2021 ◽  
pp. 216770262110302
Author(s):  
M. Justin Kim ◽  
Maxwell L. Elliott ◽  
Annchen R. Knodt ◽  
Ahmad R. Hariri
Keyword(s):  
Functional Connectivity ◽  
Visual Information ◽  
Past Research ◽  
Brain Regions ◽  
Small Sample ◽  
Trait Anger ◽  
Frontal Pole ◽  
Brain Correlates ◽  
Small Sample Sizes ◽  
The Right

Past research on the brain correlates of trait anger has been limited by small sample sizes, a focus on relatively few regions of interest, and poor test–retest reliability of functional brain measures. To address these limitations, we conducted a data-driven analysis of variability in connectome-wide functional connectivity in a sample of 1,048 young adult volunteers. Multidimensional matrix regression analysis showed that self-reported trait anger maps onto variability in the whole-brain functional connectivity patterns of three brain regions that serve action-related functions: bilateral supplementary motor areas and the right lateral frontal pole. We then demonstrate that trait anger modulates the functional connectivity of these regions with canonical brain networks supporting somatomotor, affective, self-referential, and visual information processes. Our findings offer novel neuroimaging evidence for interpreting trait anger as a greater propensity to provoked action, which supports ongoing efforts to understand its utility as a potential transdiagnostic marker for disordered states characterized by aggressive behavior.

scholarly journals M146. NEUROCHEMICAL MODULATION OF AUDITORY CORTEX FUNCTIONAL CONNECTIVITY IN PATIENTS WITH AUDITORY VERBAL HALLUCINATIONS

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S191-S191
Author(s):  
Sarah Weber ◽  
Helene Hjelmervik ◽  
Alexander R Craven ◽  
Erik Johnsen ◽  
Rune Kroken ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Temporal Lobe ◽  
Superior Temporal Gyrus ◽  
Underlying Mechanism ◽  
Auditory Hallucinations ◽  
Anterior Cingulate ◽  
Gamma Aminobutyric Acid ◽  
Auditory Verbal Hallucinations ◽  
Left And Right ◽  
Neurochemical Correlates

Abstract Background Auditory hallucinations have been linked to aberrant functioning of the left superior temporal gyrus (STG) and are associated with impaired cognitive control regulated by areas in the prefrontal cortex. However, the mechanisms behind these dysfunctions are still unclear. Methods The current study combined resting state connectivity fMRI with MR spectroscopy (MRS) in a sample of 81 psychosis patients to explore how neurochemical correlates of auditory hallucinations modulate left STG functioning. The analyses were focused on glutamate (Glu) and gamma-aminobutyric acid (GABA), two neurotransmitters with excitatory and inhibitory functions, respectively, since these have previously been implicated in psychosis. Results Glu and GABA showed differential relationships with left STG connectivity in patients with and without hallucinations. Specifically, Glu concentration in the anterior cingulate cortex (ACC) was positively related to functional connectivity between the left and right temporal lobe in hallucinating patients only. In contrast, GABA concentration in the ACC was negatively related to connectivity between the left and right temporal lobe in non-hallucinating patients only. Discussion These findings support a recently proposed model of interhemispheric temporal lobe miscommunication in auditory hallucinations and indicate prefrontal neurochemical modulation as a potential underlying mechanism. The results can further be integrated with previously suggested excitatory/inhibitory imbalances as neurochemical modulators in AVH.

scholarly journals Altered functional connectivity differs in stroke survivors with impaired touch sensation following left and right hemisphere lesions

2018 ◽  
Vol 18 ◽  
pp. 342-355 ◽  
Author(s):  
Peter Goodin ◽  
Gemma Lamp ◽  
Rishma Vidyasagar ◽  
David McArdle ◽  
Rüdiger J. Seitz ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Right Hemisphere ◽  
Stroke Survivors ◽  
Touch Sensation ◽  
Left And Right

scholarly journals Resting EEG Asymmetry Markers of Multiple Facets of the Behavioral Approach System: A LORETA Analysis

Symmetry ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1794
Author(s):  
Vilfredo De Pascalis ◽  
Giuliana Cirillo ◽  
Arianna Vecchio
Keyword(s):  
Frontal Lobes ◽  
Behavioral Approach ◽  
Middle Temporal Gyrus ◽  
Beta Activity ◽  
Behavioral Approach System ◽  
Superior Frontal Gyrus ◽  
Middle Temporal ◽  
Frontal Activity ◽  
Left And Right ◽  
Eeg Recordings

Previously published models of frontal activity linked high relative left frontal activity to the behavioral approach system (BAS) and impulsivity. Additionally, these models did not account for BAS facets encompassing the anticipation of reward, i.e., goal-driven persistence (BAS–GDP) and reward interest (BAS–RI), from those that deal with the actual hedonic experience of reward, i.e., reward reactivity (BAS–RR) and impulsivity (BAS–I). Using resting electroencephalographic (EEG) recordings, the source localization (LORETA) method allowed us to calculate the hemispheric asymmetry of the current density within the alpha band (7.5–13 Hz) in ten regions of interest. Compared to low BAS subtrait scorers, high BAS subtrait scorers (except for BAS–I) were correlated with greater relative left-sided activity in the superior frontal gyrus (BA10). Further, an isolated effective coherence (iCOH) analysis of the beta activity (21 Hz) disclosed that high impulsive scorers as compared to low impulsive ones had higher connectivity between the superior frontal gyrus and middle temporal gyrus, which was not compensated for by enhanced inhibitory alpha (11 Hz) connectivity between these regions. For the beta frequency, we also found in highly impulsive individuals that (i) both left and right middle temporal lobes directly influenced the activity of the left and right superior frontal lobes, and (ii) a clear decoupling between left and right superior frontal lobes. These findings could indicate reduced control by the supervisory system in more impulsive individuals.

scholarly journals Altered Functional Connectivity of the Executive Functions Network During a Stroop Task in Children with Reading Difficulties

2018 ◽  
Vol 8 (8) ◽  
pp. 516-525 ◽  
Author(s):  
Ophir Levinson ◽  
Alexander Hershey ◽  
Rola Farah ◽  
Tzipi Horowitz-Kraus
Keyword(s):  
Functional Connectivity ◽  
Executive Functions ◽  
Stroop Task ◽  
Reading Difficulties

scholarly journals Preservation of electrophysiological functional connectivity after partial corpus callosotomy: case report

2018 ◽  
Vol 22 (2) ◽  
pp. 214-219 ◽  
Author(s):  
Kaitlyn Casimo ◽  
Fabio Grassia ◽  
Sandra L. Poliachik ◽  
Edward Novotny ◽  
Andrew Poliakov ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Corpus Callosum ◽  
Seizure Activity ◽  
Diffusion Tensor ◽  
Phase Locking ◽  
Corpus Callosotomy ◽  
Left And Right ◽  
Phase Locking Value ◽  
Anatomical Mri ◽  
Electrophysiological Methods

Prior studies of functional connectivity following callosotomy have disagreed in the observed effects on interhemispheric functional connectivity. These connectivity studies, in multiple electrophysiological methods and functional MRI, have found conflicting reductions in connectivity or patterns resembling typical individuals. The authors examined a case of partial anterior corpus callosum connection, where pairs of bilateral electrocorticographic electrodes had been placed over homologous regions in the left and right hemispheres. They sorted electrode pairs by whether their direct corpus callosum connection had been disconnected or preserved using diffusion tensor imaging and native anatomical MRI, and they estimated functional connectivity between pairs of electrodes over homologous regions using phase-locking value. They found no significant differences in any frequency band between pairs of electrodes that had their corpus callosum connection disconnected and those that had an intact connection. The authors’ results may imply that the corpus callosum is not an obligatory mediator of connectivity between homologous sites in opposite hemispheres. This interhemispheric synchronization may also be linked to disruption of seizure activity.

Note on a Failure to Find Hemispheric Asymmetries for a Small Sample of Strongly Left- and Right-Handed Males and Females Using Verbal and Visuo-Spatial Recall

1980 ◽  
Vol 51 (1) ◽  
pp. 139-145 ◽  
Author(s):  
David K. Charman
Keyword(s):  
Visual Field ◽  
Small Sample ◽  
Hemispheric Asymmetries ◽  
Left Handed ◽  
Negative Findings ◽  
Left And Right ◽  
Males And Females ◽  
Spatial Positioning ◽  
Female Subjects

A column of letters was presented to the left, right, or center of the visual field of 10 male and 10 female subjects. 5 of each sex were either strongly left- or right-handed. The subjects' task was to position correctly the letters on a recall sheet. No significant hemispheric asymmetries emerged, a result that reflects other negative findings. The 10 females were significantly better at verbal identification; this was congruent with the literature. The 10 males and 10 females were equal in visuo-spatial (positioning) judgments; this did not support the literature. The 5 right-handed males were significantly inferior to the 5 left-handed males and the 10 females at positioning judgments, a result that remained unexplained. The findings were discussed in terms of other contradictory findings.

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