scholarly journals Treatment of Epithelioid Sarcoma at the Royal Marsden Hospital

Sarcoma ◽  
2003 ◽  
Vol 7 (3-4) ◽  
pp. 149-152 ◽  
Author(s):  
L. Livi ◽  
N. Shah ◽  
F. Paiar ◽  
C. Fisher ◽  
I. Judson ◽  
...  
Keyword(s):  
Local Recurrence ◽  
External Beam Radiotherapy ◽  
Epithelioid Sarcoma ◽  
Entire Group ◽  
External Beam ◽  
Pathological Features ◽  
Royal Marsden Hospital ◽  
Two Phases ◽  
Clinical And Pathological Features ◽  
Cause Specific Survival

Purpose:The aim of this study was to assess treatment and outcome with respect to clinical and pathological features.Patients and methods:Thirty-nine patients were identified (range 7–66 years, mean 23). Initial treatment comprised local excision in 11 patients and wide excision in 14. Post-operative external beam radiotherapy was prescribed in 22 patients with a total dose of 60 Gy, delivered in two phases.Results:The cause-specific survival for the entire group was 79, 63, 56 and 45% at 1, 3, 5 and 10 years, respectively. A distal limb location was associated with a better prognosis than proximal limb location (P= 0.04).Conclusions:Our data favour treatment with wide functional excision followed by radical dose radiotherapy in attempt to minimize risk of local recurrence, especially when primary tumours are bigger than 3 cm. Our data also suggest the same treatment for local recurrence, when technically possible, to avoid amputation.

Primary Epithelioid Sarcoma of the Neck: a Rare Case Report

Medicina ◽  
2012 ◽  
Vol 48 (1) ◽  
pp. 8
Author(s):  
Viktoras Rudžianskas ◽  
Elona Juozaitytė ◽  
Arturas Inčiūra ◽  
Valdas ◽  
Milda Rudžianskienė
Keyword(s):  
Case Report ◽  
Local Recurrence ◽  
Distant Metastasis ◽  
Poor Prognosis ◽  
Rare Case ◽  
External Beam Radiotherapy ◽  
Epithelioid Sarcoma ◽  
External Beam ◽  
Rare Case Report

This report presents a case of a neck epithelioid sarcoma in a 20-year-old man with poor prognosis. The patient underwent surgery followed by external beam radiotherapy and brachytherapy performed as a boost. The treatment was well-tolerated, and there was no local recurrence or distant metastasis.

Salvage brachytherapy for local recurrence after radical prostatectomy and subsequent external beam radiotherapy

Urology ◽  
2003 ◽  
Vol 62 (6) ◽  
pp. 1068-1072 ◽  
Author(s):  
Andrea Losa ◽  
Luciano Dante Nava ◽  
Nadia Di Muzio ◽  
Paola Mangili ◽  
Barbara Longobardi ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Local Recurrence ◽  
External Beam Radiotherapy ◽  
External Beam ◽  
Salvage Brachytherapy

A comparison of overall and cause-specific survival among patients with low- and intermediate-risk prostate cancer treated with brachytherapy, external beam radiotherapy, or radical prostatectomy

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 5126-5126 ◽  
Author(s):  
J. P. Ciezki ◽  
C. A. Reddy ◽  
P. A. Kupelian ◽  
E. A. Klein ◽  
C. Robinson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
External Beam Radiotherapy ◽  
Smoking History ◽  
External Beam ◽  
Intermediate Risk ◽  
Charlson Score ◽  
Risk Of Death ◽  
Risk Prostate Cancer ◽  
Cause Specific Survival

5126 Background: The factors thought to influence overall survival (OS) and cause-specific survival (CSS) in patients treated for low and intermediate-risk prostate cancer (CaP) with brachytherapy (PI), external beam radiotherapy (RT), or radical prostatectomy (RP) were evaluated. Methods: From 1996 to 2003, 2285 patients with low or intermediate-risk CaP were treated at the Cleveland Clinic with either PI (n=662), RT (n=570), or RP (n=1053). Factors thought to influence OS and CSS were recorded. These factors included: Charlson score, age, socioeconomic status, race, body mass index (BMI), presence of coronary artery disease (CAD), presence of hypertension (HTN), presence of dyslipidemia (DL), initial prostate-specific antigen (iPSA), biopsy Gleason score (bGS), clinical stage, use of androgen deprivation (AD), AD duration, smoking history including pack-years, alcohol use, and cancer treatment modality (TX). Univariate and multivariate analyses were done using Cox proportional hazards regression. Results: The median follow-up is 59 months (range: 24–119 months). The 5- year OS rate is 96.0%, and the 8-year rate is 89.9%. Multivariate analysis revealed that Charlson score, age, smoking history, and TX were significantly associated with OS. Treatment with RT was independently associated with worse OS relative to PI and RP. CSS was grouped into 4 major categories: CAD, CaP, other cancer, and other. The only significant difference between these CSS categories and the treatment modalities was CaP. The percent of deaths due to CaP in the TX groups were: PI - 3.2%, RP - 9.7%, and RT - 24.5%. Conclusions: Charlson score, age, smoking history, and TX independently affect OS in patients treated for low and intermediate-risk CaP. The cause of the lower OS rate with RT may be related to an increased risk of death due to CaP. [Table: see text] No significant financial relationships to disclose.

Exophytic and Ulcerated Local Recurrence of Papillary Thyroid Carcinoma with Spectacular Response to External Beam Radiotherapy

Thyroid ◽  
2008 ◽  
Vol 18 (9) ◽  
pp. 1015-1016 ◽  
Author(s):  
Anastasios Gkountouvas ◽  
Dimitrios Thomas ◽  
Athanasia Tertipi ◽  
Konstantinos Chrysanthou ◽  
Philippos Kaldrimidis
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Local Recurrence ◽  
Thyroid Carcinoma ◽  
External Beam Radiotherapy ◽  
External Beam ◽  
Papillary Thyroid

scholarly journals MULTIPARAMETRIC MRI IN PATIENTS WITH LOCALIZED PROSTATE CANCER AFTER RADICAL EXTERNAL RADIOTHERAPY

2019 ◽  
pp. 32-41
Author(s):  
M. V. Krupina ◽  
T. N. Trofimova ◽  
M. Y. Valkov
Keyword(s):  
Prostate Cancer ◽  
Local Recurrence ◽  
Current Knowledge ◽  
External Beam Radiotherapy ◽  
Locally Advanced ◽  
Local Relapse ◽  
Multiparametric Mri ◽  
Imaging Method ◽  
External Beam ◽  
Local Progression

Prostate cancer (PC) is the one of the most common and socially significant malignancies in men. Radiotherapy is currently one of the leading conservative special treatments for a localized and locally advanced PC. The frequency of biochemical recurrence after external beam radiotherapy (EBRT) is high. One of the main problems is a differentiation between local and systemic relapse of PC. Nevertheless, a local recurrence of PC after radiotherapy can occur without increasing PSA. Magnetic resonance imaging (MRI) is a highly informative imaging method, however, currently it is used mostly for the primary diagnosis and is not included into the recommendations for detecting recurrent prostate cancer after treatment. MR-pattern of the local progression after radical EBRT can be similar to that of primary PC. It is also difficult to diagnose local relapse of prostate cancer in some cases. Multiparametric MRI (mpMRI) has the greatest prospects in the diagnosis of local tumor recurrence in prostate cancer patients after radical external beam radiotherapy. The article provides an overview of domestic and foreign literature, in which we attempted to systematize current knowledge about the possibilities of the mpMRI in diagnosing local recurrence after radical EBRT and, based on the results of published studies, identify directions for further application of this approach.

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