Purpose: The purpose of this study was to compare the self-efficacy, depression, and health promotion behaviors of nursing and non-nursing female college students, and to develop a program to improve the health promotion behaviors of female college students. Methods: One hundred sixty-six females (84 nursing, 82 non-nursing) college students participated in the study. Data collection was conducted between November 20 and December 8, 2017. Data was analyzed using descriptive statistics, ${chi}^2$ test, ANCOVA, t-test, ANOVA, Pearson's correlation coefficients and stepwise multiple regression analysis with the SPSS/WIN 22.0. Results: The results of health promotion behaviors of the nursing college students were higher than non-nursing college students (F=7.14, p=.008). Both nursing and non-nursing college students showed a positive correlation between health promotion behaviors and self-efficacy, and there was a negative correlation between health promotion behaviors and depression. Self-efficacy was the most influential factor in health promotion behaviors for both nursing and non-nursing female college students. Conclusion: In order to improve the health promotion behaviors of female college students, it is necessary to educate individuals to help them improve their self-efficacy and be able to maintain healthy lifestyles by perceiving and managing their own health conditions.