Can pharmacotherapy improve treatment outcomes in people with co-occurring major depressive and cocaine use disorders?

Author(s):  
Gustavo A. Angarita ◽  
Hasti Hadizadeh ◽  
Ignacio Cerdena ◽  
Marc N. Potenza
2008 ◽  
Vol 21 (4) ◽  
pp. 278-286 ◽  
Author(s):  
Tracy S. Hunter

Optimal levels of the bioactive folate are necessary for maintaining proper brain and body functioning. Folate deprivation and impaired folate metabolism are clinically associated with defects in the developing nervous system. Numerous studies implicate a deficiency of bioactive folate with an increased risk of major depressive disorder and other neuropsychiatric disorders. Bioactive forms of folate, particularly L-methylfolate, have been found to augment the therapeutic efficacy of antidepressants in patients with major depressive disorder, who fail to adequately respond to standard therapies. The antidepressant action of L-methylfolate appears to improve treatment outcomes most effectively when administered as an adjuvant to traditional antidepressants. This new understanding of the role of folates in major depressive disorder and other mood disorders offers opportunities to improve treatment outcomes.


Innova ◽  
2020 ◽  
Vol 20 (3) ◽  
pp. 18-24
Author(s):  
Максим Юрьевич Гончаров ◽  
◽  
Яна Алексеевна Горева ◽  

The problem of early diagnosis of non-specific purulent diseases of the spine remains relevant. The main organizational problems in providing medical care to these patients are considered to be late diagnosis, late administration of antibacterial therapy and neurosurgical care. The goal of our work was to improve treatment outcomes by reducing the time of diagnosis and the duration of the stage before providing specialized care. Based on the identified variable factors that influenced the treatment outcomes, we proposed an algorithm for the diagnosis and treatment of non-specific purulent diseases of the spine, implemented in the activities of hospitals in the Sverdlovsk region. To evaluate the effectiveness of our proposed algorithm, we retrospectively compared the main indicators and results of the treatment of patients conducted before and after the implementation of the developed algorithm. Educational and methodological work with doctors was also important for reducing the time of diagnosis of the disease. After the implementation of the developed algorithm of diagnostics and tactics in nonspecific suppurative diseases of the spine and the necessary organizational issues, there was a reduction of the duration from the first signs of the disease to provide specialized assistance, as well as the number of patients who had gross neurological deficit and/or systemic inflammatory response syndrome upon admission to a hospital. The results obtained allow us to recommend the developed algorithm of diagnostics and tactics for non-specific purulent diseases of the spine for implementation in other regions of the Russian Federation.


2019 ◽  
Vol 14 (10) ◽  
pp. S317-S318
Author(s):  
M. Welliver ◽  
F. Jin ◽  
J. Amann ◽  
M. Koenig ◽  
X. Mo ◽  
...  

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