Clinical significance of glucocorticoid receptor expression in premature infants with respiratory distress syndrome

2016 ◽  
Vol 30 (4) ◽  
pp. 430-433 ◽  
Author(s):  
Fevzi Ataseven ◽  
Osman Salis ◽  
Canan Aygun ◽  
Abdulkerim Bedir ◽  
Sukru Kucukoduk
Keyword(s):  
Glucocorticoid Receptor ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Clinical Significance ◽  
Premature Infants ◽  
Distress Syndrome ◽  
Receptor Expression

scholarly journals 1342 CORD BLOOD THYROID FUNCTION STUDIES IN PREMATURE INFANTS WITH AND WITHOUT RESPIRATORY DISTRESS SYNDROME (RDS)

1981 ◽  
Vol 15 ◽  
pp. 667-667
Author(s):  
Alan H Klein ◽  
Barbara Foley ◽  
Thomas P Foley ◽  
Hugh H Macdonald ◽  
Delbert A Fisher
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Cord Blood ◽  
Thyroid Function ◽  
Premature Infants ◽  
Distress Syndrome

PLASMA CORTICOSTEROIDS IN INFANTS WITH THE RESPIRATORY DISTRESS SYNDROME

PEDIATRICS ◽  
1973 ◽  
Vol 52 (6) ◽  
pp. 782-787 ◽  
Author(s):  
Melvin Baden ◽  
Charles R. Bauer ◽  
Eleanor Colle ◽  
George Klein ◽  
Apostolos Papageorgiou ◽  
...  
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Premature Infants ◽  
Negative Correlation ◽  
Apgar Score ◽  
Distress Syndrome ◽  
Serum Concentrations ◽  
Response To Stress ◽  
Minute Apgar Score

Plasma total corticosteroid concentrations were measured in 44 premature infants with the respiratory distress syndrome (RDS). Further assay of serum concentrations of cortisol, cortisone, corticosterone, corticosterone sulfate, and 11-deoxycorticosterone sufate was carried out in 24 of these infants and in 10 healthy, nonstressed premature controls. Infants with RDS had higher concentrations of cortisol (22.1±4.3µg/100 ml) and corticosterone sulfate (7.7 ± 0.8 µg/100 ml) than control infants (6.6 ± 0.8 µg/100 ml, 1.2 ± 0.3 µg/100 ml, and 4.2 ± 0.4 µg/100 ml, respectively). A significant correlation was found with the five-minute Apgar score (negative correlation, p = 0.005) and a possible correlation with the A-aDO2 gradient. Among premature infants with RDS, those of 32 weeks' gestation or less had higher concentrations of cortisol (28.3 ± 23.6 µg/100 ml) and corticosterone (3.9 ± 2.7 µg/100 ml) than those of more than 32 weeks (11.5 ± 5.4 µg/100 ml and 1.7 ± 0.7 µg/100 ml, respectively), suggesting either elevated response to stress or a diminished ability to metabolize these compounds.

Hypercoagulability in Premature Infants with Special Reference to the Respiratory Distress Syndrome and Hemorrhage

Neonatology ◽  
1971 ◽  
Vol 17 (1-2) ◽  
pp. 98-111 ◽  
Author(s):  
Marguerite Markarian ◽  
L.O. Lubchenco ◽  
Eliana Rosenblüt ◽  
F. Fernandez ◽  
D. Lang ◽  
...  
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Special Reference ◽  
Premature Infants ◽  
Distress Syndrome

scholarly journals Vitamin D deficiency and its effect on respiratory distress syndrome in premature infants: results from a prospective study in a tertiary care centre

2020 ◽  
Vol 20 (1) ◽  
pp. 437-443
Author(s):  
Pelin Dogan ◽  
Hilal Ozkan ◽  
Nilgun Koksal ◽  
Onur Bagci ◽  
Ipek Guney Varal
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Prospective Study ◽  
Premature Infants ◽  
Lung Development ◽  
Distress Syndrome ◽  
Tertiary Care ◽  
Hydroxyvitamin D ◽  
Positive Effects ◽  
25 Hydroxyvitamin D

Background: The positive effects of steroids on lung development are well known, and 1,25-dihydroxy vitamin D3 has been shown to exert positive effects on fetal lung development. Objective: We aimed to investigate the relationship between 25-hydroxyvitamin D [25(OH)D] levels and respiratory distress syn- drome (RDS) in premature infants. Methods: Infants aged ≤32 gestational weeks who were admitted to the neonatal intensive care unit (NICU) during 1 year were enrolled in this prospective study. 25(OH)D levels were obtained at the time of admission to NICU. Patients were divided into three groups according to their 25(OH)D levels: severe (group 1), moderate (group 2), and mild (group 3) 25(OH)D deficiencies. Results: The study comprised 72 patients; of them, RDS was observed in 49 and not observed in 23 patients. The mean 25(OH)D levels were significantly lower in RDS patients (p=0.04). Multivariate analysis showed that patients with higher 25(OH)D levels can be preventive for the development of RDS (odds ratio 0.89; 95% confidence interval 0.8–0.99; p=0.04). Conclusion: Our study revealed that 25(OH)D deficiency is an independent risk factor for RDS in premature infants. However, further studies are necessary to explore the association between 25(OH)D deficiency and RDS. Keywords: 25-hydroxyvitamin D; prematurity; respiratory distress syndrome. 

Sign in / Sign up

Export Citation Format

Share Document