PLASMA CORTICOSTEROIDS IN INFANTS WITH THE RESPIRATORY DISTRESS SYNDROME

PEDIATRICS ◽  
1973 ◽  
Vol 52 (6) ◽  
pp. 782-787 ◽  
Author(s):  
Melvin Baden ◽  
Charles R. Bauer ◽  
Eleanor Colle ◽  
George Klein ◽  
Apostolos Papageorgiou ◽  
...  
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Premature Infants ◽  
Negative Correlation ◽  
Apgar Score ◽  
Distress Syndrome ◽  
Serum Concentrations ◽  
Response To Stress ◽  
Minute Apgar Score

Plasma total corticosteroid concentrations were measured in 44 premature infants with the respiratory distress syndrome (RDS). Further assay of serum concentrations of cortisol, cortisone, corticosterone, corticosterone sulfate, and 11-deoxycorticosterone sufate was carried out in 24 of these infants and in 10 healthy, nonstressed premature controls. Infants with RDS had higher concentrations of cortisol (22.1±4.3µg/100 ml) and corticosterone sulfate (7.7 ± 0.8 µg/100 ml) than control infants (6.6 ± 0.8 µg/100 ml, 1.2 ± 0.3 µg/100 ml, and 4.2 ± 0.4 µg/100 ml, respectively). A significant correlation was found with the five-minute Apgar score (negative correlation, p = 0.005) and a possible correlation with the A-aDO2 gradient. Among premature infants with RDS, those of 32 weeks' gestation or less had higher concentrations of cortisol (28.3 ± 23.6 µg/100 ml) and corticosterone (3.9 ± 2.7 µg/100 ml) than those of more than 32 weeks (11.5 ± 5.4 µg/100 ml and 1.7 ± 0.7 µg/100 ml, respectively), suggesting either elevated response to stress or a diminished ability to metabolize these compounds.

scholarly journals Frequency of neonatal complications after premature delivery

2013 ◽  
Vol 3 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Gordana Grgić ◽  
Elvira Brkičević ◽  
Dženita Ljuca ◽  
Edin Ostrvica ◽  
Azur Tulumović
Keyword(s):  
Body Weight ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Intracranial Hemorrhage ◽  
Premature Infants ◽  
Apgar Score ◽  
Distress Syndrome ◽  
Premature Delivery ◽  
Average Body ◽  
Average Body Weight

Introduction: Preterm delivery is the delivery before 37 weeks of gestation are completed. The incidence of preterm birth ranges from 5 to 15%. Aims of the study were to determine the average body weight, Apgar score after one and five minutes, and the frequency of the most common complications in preterminfants.Methods: The study involved a total of 631 newborns, of whom 331 were born prematurely Aims of this study were to (24th-37th gestational weeks-experimental group), while 300 infants were born in time (37-42 weeks of gestation-control group).Results: Average body weight of prematurely born infants was 2382 grams, while the average Apgar score in this group after the fi rst minute was 7.32 and 7.79 after the fifth minute. The incidence of respiratory distress syndrome was 50%, intracranial hemorrhage, 28.1% and 4.8% of sepsis. Respiratory distresssyndrome was more common in infants born before 32 weeks of gestation. Mortality of premature infants is present in 9.1% and is higher than that of infants born at term.Conclusions: Birth body weight and Apgar scores was lower in preterm infants. Respiratory distress syndrome is the most common fetal complication of prematurity. Intracranial hemorrhage is the second most common complication of prematurity. Mortality of premature infants is higher than the mortality of infants born at term birth.

scholarly journals Analysis of the perinatal risk causes and the structure of pathology in premature children in Chelyabinsk, born with extremely low and very low body weight

2019 ◽  
Vol 64 (4) ◽  
pp. 92-98
Author(s):  
A. N. Uzunova ◽  
N. A. Onishcenko
Keyword(s):  
Body Weight ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Bronchopulmonary Dysplasia ◽  
Premature Infants ◽  
Apgar Score ◽  
Intraventricular Hemorrhage ◽  
Distress Syndrome ◽  
Congenital Deformity ◽  
Perinatal Risk

The purpose of the study is to analyze the history and structure of the pathology of premature infants with extremely low body weight and very low body weight under dynamic follow up in the monitoring department for children of the perinatal risk group. Using the method of continuous sampling we analyzed observation maps of 95 premature infants with extremely low body weight and very low body weight of gestation age from 24 to 36 weeks.All newborns have a low Apgar score at birth and at the 5th minute, and Apgar score was lower in  children with extremely low body weight as compared with children with very low body weight. All children had congenital anomalies of the organs and systems, marked signs of immaturity, with prevailing changes in  the cardiovascular system, passability of  the renal pelvis, and congenital deformity of thigh.Among the conditions that occurred in the perinatal period, the authors diagnosed intraventricular hemorrhage in 50.5% of patients, 89.6% of them had hemorrhage of grade II – III, all children had respiratory distress syndrome. Bronchopulmonary dysplasia was diagnosed in 60% of premature infants, its moderate and severe forms in 1/3 of the patients. All children had anemia, and 13.7% of children had a neonatal syndrome from mothers with diabetes mellitus. 1/3 of premature infants had retinopathy; its frequency did not depend on the body weight at birth. All children had a combination of pathologies. Bronchopulmonary dysplasia was combined with respiratory distress syndrome and anemia in 100% of children. The combination of bronchopulmonary dysplasia with intraventricular hemorrhage was more often recorded in patients with extremely low body weight than in patients with very low body weight. 

scholarly journals 1342 CORD BLOOD THYROID FUNCTION STUDIES IN PREMATURE INFANTS WITH AND WITHOUT RESPIRATORY DISTRESS SYNDROME (RDS)

1981 ◽  
Vol 15 ◽  
pp. 667-667
Author(s):  
Alan H Klein ◽  
Barbara Foley ◽  
Thomas P Foley ◽  
Hugh H Macdonald ◽  
Delbert A Fisher
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Cord Blood ◽  
Thyroid Function ◽  
Premature Infants ◽  
Distress Syndrome

Hypercoagulability in Premature Infants with Special Reference to the Respiratory Distress Syndrome and Hemorrhage

Neonatology ◽  
1971 ◽  
Vol 17 (1-2) ◽  
pp. 98-111 ◽  
Author(s):  
Marguerite Markarian ◽  
L.O. Lubchenco ◽  
Eliana Rosenblüt ◽  
F. Fernandez ◽  
D. Lang ◽  
...  
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Special Reference ◽  
Premature Infants ◽  
Distress Syndrome

scholarly journals Vitamin D deficiency and its effect on respiratory distress syndrome in premature infants: results from a prospective study in a tertiary care centre

2020 ◽  
Vol 20 (1) ◽  
pp. 437-443
Author(s):  
Pelin Dogan ◽  
Hilal Ozkan ◽  
Nilgun Koksal ◽  
Onur Bagci ◽  
Ipek Guney Varal
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Prospective Study ◽  
Premature Infants ◽  
Lung Development ◽  
Distress Syndrome ◽  
Tertiary Care ◽  
Hydroxyvitamin D ◽  
Positive Effects ◽  
25 Hydroxyvitamin D

Background: The positive effects of steroids on lung development are well known, and 1,25-dihydroxy vitamin D3 has been shown to exert positive effects on fetal lung development. Objective: We aimed to investigate the relationship between 25-hydroxyvitamin D [25(OH)D] levels and respiratory distress syn- drome (RDS) in premature infants. Methods: Infants aged ≤32 gestational weeks who were admitted to the neonatal intensive care unit (NICU) during 1 year were enrolled in this prospective study. 25(OH)D levels were obtained at the time of admission to NICU. Patients were divided into three groups according to their 25(OH)D levels: severe (group 1), moderate (group 2), and mild (group 3) 25(OH)D deficiencies. Results: The study comprised 72 patients; of them, RDS was observed in 49 and not observed in 23 patients. The mean 25(OH)D levels were significantly lower in RDS patients (p=0.04). Multivariate analysis showed that patients with higher 25(OH)D levels can be preventive for the development of RDS (odds ratio 0.89; 95% confidence interval 0.8–0.99; p=0.04). Conclusion: Our study revealed that 25(OH)D deficiency is an independent risk factor for RDS in premature infants. However, further studies are necessary to explore the association between 25(OH)D deficiency and RDS. Keywords: 25-hydroxyvitamin D; prematurity; respiratory distress syndrome. 

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