Genetic variation in the maternal vitamin D receptor FokI gene as a risk factor for recurrent pregnancy loss

Many studies have reported the association of VEGF-1154G/A, VEGF 936C/T and p53 Arg72Pro polymorphisms with Recurrent Pregnancy Loss (RPL), but the outcomes are inconsistent. We have used meta-analysis to associate these polymorphisms with RPL, having the spiral artery remodelling as a major risk factor. The studies were identified from three different reputed databases, namely Science direct, PubMed/Medline and Scopus. The eligible studies of VEGF-1154G/A, VEGF 936C/T and p53Arg72Pro polymorphisms associated with the RPL were selected for the analysis. They were segregated into three different ethnic groups as Asians, Caucasians and mixed population. For the analysis, the overall prevalence, Odds ratio, Risk ratio, Relative risk ratio and P values were calculated. A total of 3241 RPL cases and 3205 healthy controls from 21 different case-control studies were analysed. RPL was highly prevalent in mixed population with VEGF-1154G/A and p53 Arg72Pro polymorphisms (70.04% and 66.46% respectively) and in Asian population with VEGF 936C/T polymorphism (53.58%). The homozygous recessive genotypes of VEGF and p53 exhibited significant association between the respective polymorphisms and RPL along with the increased risk of outcome. The current analysis conclusively reports the geographic distribution of the different genetic polymorphisms which shows high association with the progression of RPL. Understanding the spectrum of polymorphisms on different population with the spiral artery remodelling as a risk factor encloses the importance of the vasculature during the pregnancy.

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Antiphosphatidylethanolamine antibodies might not be an independent risk factor for further miscarriage in patients suffering recurrent pregnancy loss

Journal of Reproductive Immunology ◽

10.1016/j.jri.2010.03.002 ◽

2010 ◽

Vol 85 (2) ◽

pp. 186-192 ◽

Cited By ~ 11

Author(s):

Shintaro Obayashi ◽

Yasuhiko Ozaki ◽

Toshitaka Sugi ◽

Tamao Kitaori ◽

Kinue Katano ◽

...

Keyword(s):

Risk Factor ◽

Pregnancy Loss ◽

Independent Risk Factor ◽

Recurrent Pregnancy Loss ◽

Antiphosphatidylethanolamine Antibodies

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Vitamin D, autoimmunity and recurrent pregnancy loss: More than an association

American Journal of Reproductive Immunology ◽

10.1111/aji.12991 ◽

2018 ◽

Vol 80 (3) ◽

pp. e12991 ◽

Cited By ~ 14

Author(s):

Kassem Sharif ◽

Yousra Sharif ◽

Abdulla Watad ◽

Yarden Yavne ◽

Benjamin Lichtbroun ◽

...

Keyword(s):

Vitamin D ◽

Pregnancy Loss ◽

Recurrent Pregnancy Loss

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Abstract 14592: Pregnancy Loss and Cardiovascular Disease Risk Factors in Early Adulthood: Preliminary Findings From Add Health

Circulation ◽

10.1161/circ.142.suppl_3.14592 ◽

2020 ◽

Vol 142 (Suppl_3) ◽

Author(s):

Yamnia I Cortes ◽

Shuo Zhang ◽

Diane C Berry ◽

Jon Hussey

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Risk Factor ◽

Pregnancy Loss ◽

Recurrent Pregnancy Loss ◽

Early Adulthood ◽

Add Health ◽

Cvd Risk Factors ◽

Cvd Risk ◽

Live Births

Introduction: Pregnancy loss, including miscarriage and stillbirth, affect 15-20% of pregnancies in the United States annually. Accumulating evidence suggests that pregnancy loss is associated with greater cardiovascular disease (CVD) burden later in life. However, associations between pregnancy loss and CVD risk factors in early adulthood (age<35 years) have not been assessed. Objective: To examine associations between pregnancy loss and CVD risk factors in early adulthood. Methods: We conducted a secondary data analysis using the public-use data set for Wave IV (2007-2009) of the National Longitudinal Study of Adolescent to Adult Health (Add Health). Our sample consisted of women, ages 24-32 years, with a previous pregnancy who completed biological data collection (n=2,968). Pregnancy loss was assessed as any history of miscarriage or stillbirth; and as none, one, or recurrent (≥2) pregnancy loss. Dependent variables included physical measures and blood specimens: body mass index (BMI), blood pressure, diabetes status, and dyslipidemia. Associations between pregnancy loss and each CVD risk factor were tested using linear (for BMI) and logistic regression adjusting for sociodemographic factors, parity, pre-pregnancy BMI, smoking during pregnancy, and depression. Results: Six hundred and ninety-three women (23%) reported a pregnancy loss, of which 21% reported recurrent pregnancy loss. Women with all live births were more likely to identify as non-Hispanic White (73%) and report a higher annual income. After adjusting for sociodemographics (age, race/ethnicity, education, income), pregnancy loss was associated with a greater BMI (ß=0.90; SE,0.39). In fully-adjusted models, women with recurrent pregnancy loss were more likely to have hypertension (AOR, 2.50; 95%CI, 1.04-5.96) and prediabetes (AOR, 1.93; 95%CI. 1.11-3.37) than women with all live births; the association was non-significant for women with one pregnancy loss. Conclusions: Pregnancy loss is associated with a more adverse CVD risk factor profile in early adulthood. Findings suggest the need for CVD risk assessment in young women with a prior pregnancy loss. Further research is necessary to identify underlying risk factors of pregnancy loss that may predispose women to CVD.

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Genetic variation in the human vitamin D receptor is associated with muscle strength, fat mass and body weight in Swedish women

Acta Endocrinologica ◽

10.1530/eje.0.1500323 ◽

2004 ◽

pp. 323-328 ◽

Cited By ~ 115

Author(s):

E Grundberg ◽

H Brandstrom ◽

EL Ribom ◽

O Ljunggren ◽

H Mallmin ◽

...

Keyword(s):

Vitamin D ◽

Body Weight ◽

Genetic Variation ◽

Muscle Strength ◽

Body Mass ◽

Vitamin D Receptor ◽

Fat Mass ◽

Restriction Site ◽

Mineral Density ◽

Healthy Women

OBJECTIVE: Bone mineral density (BMD) is under strong genetic control and a number of candidate genes have been associated with BMD. Both muscle strength and body weight are considered to be important predictors of BMD but far less is known about the genes affecting muscle strength and fat mass. The purpose of this study was to investigate the poly adenosine (A) repeat and the BsmI SNP in the vitamin D receptor (VDR) in relation to muscle strength and body composition in healthy women. DESIGN: A population-based study of 175 healthy women aged 20-39 years was used. METHODS: The polymorphic regions in the VDR gene (the poly A repeat and the BsmI SNP) were amplified by PCR. Body mass measurements (fat mass, lean mass, body weight and body mass index) and muscle strength (quadriceps, hamstring and grip strength) were evaluated. RESULTS: Individuals with shorter poly A repeat, ss and/or absence of the linked BsmI restriction site (BB) have higher hamstring strength (ss vs LL, P=0.02), body weight (ss vs LL, P=0.049) and fat mass (ss vs LL, P=0.04) compared with women with a longer poly A repeat (LL) and/or the presence of the linked BsmI restriction site (bb). CONCLUSIONS: Genetic variation in the VDR is correlated with muscle strength, fat mass and body weight in premenopausal women. Further functional studies on the poly A microsatellite are needed to elucidate whether this is the functionally relevant locus or if the polymorphism is in linkage disequilibrium with a functional variant in a closely situated gene further downstream of the VDR 3'UTR.

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168: No additional value of first trimester maternal vitamin D over risk factor screening for predicting adverse pregnancy outcomes

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2012.10.333 ◽

2013 ◽

Vol 208 (1) ◽

pp. S82-S83

Author(s):

Francisco Schneuer ◽

Natasha Nassar ◽

Vitomir Tasevski ◽

Anthony Ashton ◽

Christine Roberts ◽

...

Keyword(s):

Vitamin D ◽

Risk Factor ◽

Pregnancy Outcomes ◽

First Trimester ◽

Adverse Pregnancy Outcomes ◽

Factor Screening ◽

Maternal Vitamin ◽

Risk Factor Screening ◽

Adverse Pregnancy ◽

Additional Value

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Prominent Levels of the Profibrotic Chemokine CCL18 during Peritonitis: In Vitro Downregulation by Vitamin D Receptor Agonists

BioMed Research International ◽

10.1155/2018/6415892 ◽

2018 ◽

Vol 2018 ◽

pp. 1-12 ◽

Cited By ~ 2

Author(s):

Marta Ossorio ◽

Virginia Martínez ◽

Maria-Auxiliadora Bajo ◽

Gloria Del Peso ◽

Maria-José Castro ◽

...

Keyword(s):

Vitamin D ◽

Risk Factor ◽

Vitamin D Receptor ◽

Peritoneal Macrophages ◽

Peritoneal Membrane ◽

Pharmacological Interventions ◽

Membrane Function ◽

Bacterial Peritonitis ◽

Ultrafiltration Failure

Peritoneal dialysis (PD) is used as a renal replacement therapy, which can be limited by peritoneal membrane ultrafiltration failure (UFF) secondary to fibrotic processes. Peritonitis, a frequent complication of PD, is a major risk factor for peritoneal membrane fibrosis and UFF. Low peritoneal levels of the chemokine CCL18 are associated with preservation of peritoneal membrane function in PD. Given that CCL18 is involved in fibrotic processes and recurrent peritonitis, it is a risk factor for peritoneal membrane failure; thus, we evaluated CCL18 concentrations in peritoneal effluents from patients undergoing peritonitis episodes. Pharmacological interventions aimed at diminishing the production of CCL18 were also explored. Fivefold higher CCL18 peritoneal concentrations were found during acute bacterial peritonitis, in parallel with the increased infiltration of macrophages. Unexpectedly, CCL18 was also highly (50-fold) increased during sterile eosinophilic peritonitis, and peritoneal eosinophils were found to express CCL18. In vitro treatment of peritoneal macrophages with the vitamin D receptor agonist paricalcitol was able to reduce the secretion and the expression of CCL18 in isolated peritoneal macrophages. In conclusion, our study suggests that the chemokine CCL18 can be a mediator of peritoneal membrane failure associated with peritonitis episodes as well as providing a new potential therapeutic target.

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