scholarly journals Hydroxyl and superoxide anion radical scavenging activities of natural source antioxidants using the computerized JES-FR30 ESR spectrometer system

IUBMB Life ◽  
1997 ◽  
Vol 42 (1) ◽  
pp. 35-44 ◽  
Author(s):  
Yasuko Noda ◽  
Akitane Mori ◽  
Lester Packer ◽  
Kazunori Anzai ◽  
Masahiro Kohno ◽  
...  
Keyword(s):  
Superoxide Anion ◽  
Anion Radical ◽  
Radical Scavenging ◽  
Superoxide Anion Radical ◽  
Natural Source ◽  
Spectrometer System

scholarly journals Effect of extraction conditions of paprika oleoresins on their free radical scavenging and anticancer activity

2014 ◽  
Vol 12 (3) ◽  
pp. 377-385 ◽  
Author(s):  
Vesna Šaponjac ◽  
Dragana Četojević-Simin ◽  
Gordana Ćetković ◽  
Jasna Čanadanović-Brunet ◽  
Sonja Djilas ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Cell Line ◽  
Antiproliferative Activity ◽  
Superoxide Anion ◽  
Anion Radical ◽  
Radical Scavenging ◽  
Superoxide Anion Radical ◽  
Food Ingredients ◽  
Supercritical Carbon

AbstractGround spice paprika was extracted with hexane, by conventional Soxhlet procedure (SX oleoresin), and with supercritical carbon dioxide at three different pressures — 20, 30 and 40 MPa (SF20, SF30 and SF40 oleoresins). The effect of extraction method and conditions on the colour intesity of paprika oleoresins, content of α-tocopherol, as well as antioxidant and antiproliferative activity was examined. Hexane showed highest selectivity for paprika pigments (886.02 ASTA), while α-tocopherol showed highest solubility (3846.9 mg kg−1) in supercritical carbon dioxide at 20 MPa. All paprika oleoresins exhibited good superoxide anion radical scavenging activity SF30 being the best superoxide anion radical scavenger. Cell growth activity was evaluated in vitro in human cell lines:cervix epitheloid carcinoma (HeLa), breast adenocarcinoma (MCF7) and colon adenocarcinoma (HT-29). The highest antiproliferative activity was exhibited by SX in MCF7 cell line (IC50=14.28 mg mL−1). Extract SF40 produced significant and selective antiproliferative action towards HeLa cell line. These results suggest that paprika oleoresins, due to high antiradical and tumor cell-inhibiting activity, can be regarded as functional food ingredients.

Antioxidant and ROS inhibitory activities of heterocyclic 2-Aryl-4(3H)-quinazolinone derivatives

2021 ◽  
Vol 18 ◽  
Author(s):  
Shahida Perveen ◽  
Syed Muhammad Saad ◽  
Khalid Mohammed Khan ◽  
Muhammad Iqbal Choudhary
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Free Radicals ◽  
Cell Line ◽  
Superoxide Anion ◽  
Anion Radical ◽  
Radical Scavenging ◽  
Superoxide Anion Radical ◽  
Inhibitory Activities ◽  
Quinazolinone Derivatives

Background: Antioxidants are small molecules that prevent or delay the process of oxidations caused by highly reactive free radicals. These molecules are known for their ability to protect various cellular architecture and other biomolecules from oxidative stress and free radicals. Thus, antioxidants play a key role in the prevention of oxidative damages caused by highly reactive free radicals. Method: In the present study, a series of previously synthesized heterocyclic 2-aryl-4(3H)-quinazolinone derivatives 1-25 was screened for antioxidant activity by employing in vitro DPPH and superoxide anion radical scavenging activities. ROS inhibitory activities were also evaluated by serum-opsonized zymosan activated whole blood phagocytes and isolated neutrophils. Cytotoxicity studies were carried out by employing an MTT assay against the 3T3 cell line. Results: Most of the 2-aryl-4(3H)-quinazolinone derivatives showed potent antioxidant activities in superoxide anion radical scavenging assay with IC50 value ranging between 0.57 µM – 48.93 µM, as compared to positive control quercetin dihydrate (IC50 = 94.1± 1.1 µM ). Compounds 5, 6, and 14 showed excellent activity in DPPH assay. Compounds 5-8, 12-15, 17, and 20 showed promising activities in the ROS inhibition assay. All compounds were found to be non-cytotoxic against the 3T3 cell line. Structure antioxidant activity has been established. Conclusion: It can be concluded that most of the heterocyclic 2-aryl-4(3H)-quinazolinone derivatives 1-25 are identified as promising antioxidant agents that are capable of fighting against free radicals and oxidative stress. Thus, they can serve as a lead towards treating oxidative stress and related pathologies.

Study on Scavenging Free Radical Activity with Polysaccharides Materials in Chuanxiong Based on Composite Properties of Biomaterials

2012 ◽  
Vol 583 ◽  
pp. 244-247
Author(s):  
Yong Guang Bi ◽  
Chun Chun Liu
Keyword(s):  
Free Radical ◽  
Superoxide Anion ◽  
Anion Radical ◽  
Radical Scavenging ◽  
Natural Antioxidants ◽  
Superoxide Anion Radical ◽  
Dose Effect ◽  
Spectrophotometric Detection ◽  
Free Radical Activity ◽  
Composite Properties

By using spectrophotometric detection of the Chuanxiong polysaccharides on the free radical scavenging. The results show that the Chuanxiong polysaccharides on DPPH radical, hydroxyl radical (HO•) and superoxide anion radical (•) clearance. Scavenging ability with the the Chuanxiong polysaccharide concentration increased, and showed the dose-effect relationship. Concentration of 2.0mg/mL when DPPH radicals clear the rate of 35.61%, while the rate of hydroxyl radicals and superoxide anion radical scavenging, clear the rate of 57.78% and 57.14%. Chuanxiong polysaccharide is an ideal natural antioxidants and good prospects for the development of biomedical composites.

scholarly journals Superoxide anion radical scavenging activity of bilberry (Vaccinium myrtillus L.)

2010 ◽  
Vol 1 (1) ◽  
pp. 13-23 ◽  
Author(s):  
Vesna Tumbas ◽  
Jasna Čanadanović-Brunet ◽  
Lars Gille ◽  
Sonja Đilas ◽  
Gordana Ćetković
Keyword(s):  
Superoxide Anion ◽  
Anion Radical ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Vaccinium Myrtillus ◽  
Superoxide Anion Radical ◽  
Scavenging Activity ◽  
Vaccinium Myrtillus L

Note: Antioxidant Properties of Lees Produced during Sake Making Using Fugu Muscle and Fin

2003 ◽  
Vol 9 (2) ◽  
pp. 123-126 ◽  
Author(s):  
T. Nagai
Keyword(s):  
Hydroxyl Radical ◽  
Food Processing ◽  
Superoxide Anion ◽  
Anion Radical ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Superoxide Anion Radical ◽  
Industrial Wastes ◽  
Dpph Radical ◽  
Enzymatic Hydrolysates

Enzymatic hydrolysates were prepared from lees produced during sake making using fugu muscle and fin. The antioxidant properties of these hydrolysates were measured using four different methods: autoxidation test, superoxide anion radical, DPPH radical and hydroxyl radical scavenging test. The yields of enzymatic hydrolysates were around 8.0% and their protein average content 0.66 mg/mg. The lees had remarkable antioxidant properties and high superoxide anion radical and hydroxyl radical scavenging abilities in comparison with those of ascorbic acid and α-tocopherol. According to the former results, lees produced during sake making could be used as a protein source with antioxidant properties for different applications in food processing, and its use could contribute to reduce industrial wastes.

Correlation between Anthocyanins, Total Phenolics Content and Antioxidant Activity of Purple Corn (Zea mays L.)

2014 ◽  
Vol 651-653 ◽  
pp. 220-226
Author(s):  
Min Zhu ◽  
Zhen Sheng Shi ◽  
Feng Hai Li
Keyword(s):  
Superoxide Anion ◽  
Anion Radical ◽  
Total Phenolics ◽  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Superoxide Anion Radical ◽  
Scavenging Activity ◽  
Purple Corn

Six purple corn grains were chosen to investigate their antioxidant activities and the relationships between anthocyanins and phenolics contents with antioxidant activities. Purple grains were screened for their antioxidant potentials using various in-vitro models such as superoxide anion radical scavenging activity and reducing power at various concentrations. The result showed that ZS39 and FS11 exhibited the highest anthocyanins and total phenolics contents. ZS39 and FS11 also exhibited the highest superoxide anion radical scavenging activity. There was no significant difference among the reducing power of six different purple corn grain extracts. It was found that there were positive correlations between anthocyanins and superoxide anion radical scavenging activity or reducing power, R2=0.9911, R2=0.9873, respectively. Whereas the correlations between total phenolics and superoxide anion radical scavenging activity or reducing power, R2=0.9863, R2=0.9826, respectively. It suggested that purple corn appeared to be a rich and interesting source of natural antioxidants.

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