scholarly journals The prevention of carbon tetrachloride-induced hepatotoxicity in mice by α-hederin: Inhibiton of cytochrome P450 2E1 expression

IUBMB Life ◽  
1998 ◽  
Vol 45 (1) ◽  
pp. 163-170 ◽  
Author(s):  
Hye Gwang Jeong ◽  
Hyeon Yong Park
Keyword(s):  
Cytochrome P450 ◽  
Carbon Tetrachloride ◽  
Cytochrome P450 2E1

scholarly journals Increased Cytotoxicity of Carbon Tetrachloride in a Human Hepatoma Cell Line Overexpressing Cytochrome P450 2E1

2002 ◽  
Vol 30 (4) ◽  
pp. 400-405 ◽  
Author(s):  
S Takahashi ◽  
T Takahashi ◽  
S Mizobuchi ◽  
M Matsumi ◽  
K Morita ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cytochrome P450 ◽  
Carbon Tetrachloride ◽  
Cell Line ◽  
Hepatoma Cell ◽  
Mrna Level ◽  
Hepatoma Cell Line ◽  
Cytochrome P450 2E1 ◽  
Hsp70 Mrna ◽  
Potential Marker

Cytotoxic free radicals generated during the metabolism of carbon tetrachloride by cytochrome P450 2E1 (CYP2E1) are thought to cause hepatotoxicity. Here, the cytotoxic effects of carbon tetrachloride in a liver cell line expressing CYP2E1 (HLE/2E1) are compared with those in the mother cell line (HLE). The effects of carbon tetrachloride on the gene expression of HSP70, a potential marker of oxidative stress, were also examined. The viability of HLE/2E1 cells after exposure to carbon tetrachloride was significantly decreased compared with that of HLE cells. Northern blot analysis revealed that the HSP70 mRNA level was significantly increased after carbon tetrachloride treatment in both cell lines, while the magnitude of its increase was much greater in HLE/2E1 cells than in HLE cells. These results suggest that the oxidative stress induced by CYP2E1 plays an important role in the increase in cytotoxicity of carbon tetrachloride in CYP2E1-overexpressing cells.

Molecular chaperone, HSP60, and cytochrome P450 2E1 co-expression in dilated cardiomyopathy

2005 ◽  
Vol 29 (1) ◽  
pp. 51-55 ◽  
Author(s):  
L SIDORIK ◽  
R KYYAMOVA ◽  
V BOBYK ◽  
L KAPUSTIAN ◽  
O ROZHKO ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Dilated Cardiomyopathy ◽  
Molecular Chaperone ◽  
Cytochrome P450 2E1

Association of N-acetyltransferase 2 and cytochrome P450 2E1 gene polymorphisms with antituberculosis drug-induced hepatotoxicity in Western India

2013 ◽  
Vol 28 (8) ◽  
pp. 1368-1374 ◽  
Author(s):  
Vinod H Gupta ◽  
Deepak N Amarapurkar ◽  
Meenakshi Singh ◽  
Preetha Sasi ◽  
Jyotsna M Joshi ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Gene Polymorphisms ◽  
Western India ◽  
Antituberculosis Drug ◽  
Cytochrome P450 2E1 ◽  
Drug Induced
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