This chapter examines William Gibson's The Difference Engine, a collaboration with Bruce Sterling, as well as his screenplays, poetry, song lyrics, and nonfiction. Sterling used an irresistibly marketable concept for The Difference Engine: a novel by what he could describe as the two leading cyberpunk authors that would appealingly blend three popular subgenres of science fiction—cyberpunk, alternate history, and “steampunk” literature. Despite the prominence of cyberspace in his Sprawl trilogy, Gibson claimed that he has “never really been very interested in computers themselves.” This chapter first offers a reading of The Difference Engine before discussing Gibson's screenplays written for Hollywood in the late 1980s, including one for a proposed Alien 3 film and another for the film version of Johnny Mnemonic. It also considers Gibson's poems such as “The Beloved: Voices for Three Heads,” his ventures into writing song lyrics, and the approach he used in some of his later nonfiction works: looking at the real world in terms of science fiction, conveying that we indeed live in a science fiction world.