This article describes a study designed to examine the association of demographic, psychological, and environmental characteristics of a sample of low socioeconomic status, Mexican American students in elementary and middle school and their reported use of nine substances. Students in grades four, five, and six ( N = 2295; males 52% and females 48%) located in a metropolitan school district in South Texas were surveyed in order to ascertain information pertaining to the initiation and/or ongoing use of substances. Regression analyses were employed to determine the relative contribution of variables measured to lifetime use of both minor and major substances. Results indicate that a specific combination of variables were predictive of both minor and major substance use for the subjects surveyed. Implications for future research and substance intervention are included.
