Abstract
Background: Epidemiological studies have demonstrated the association between noise exposure and diabetes, but few studies have reported the relationship between noise frequency components and fasting blood glucose. This study investigated the associations between noise levels, frequency characteristics, and the incident hyperglycemia. Methods: An industry-based cohort of 905 volunteers was enrolled and followed-up from the data of first employment to 2012. Personal noise levels and octave-band frequencies of environmental noise were measured systematically in 2012 to classify subjects’ exposure retrospectively. Cox regression models were applied to calculate the relative risk (RR) of hyperglycemia by continuous and categorical noise-exposure and frequency-component levels, adjusting for potential confounders. Results: Subjects exposed to ≥80 A-weighted decibels (dBA) had an increased RR for hyperglycemia of 1.78 (95% confidence interval [CI]: 1.11, 2.84) compared with those exposed to <70 dBA. The high-exposure groups at frequencies of 31.5 (≥33 decibel [dB]), 63 (≥44 dB), 125 (≥52 dB), 250 (≥59 dB), 500 (≥65 dB), 1000 (≥68 dB), and 2000 (≥68 dB) Hz had a significantly higher risk of hyperglycemia (all p values < 0.05) than did the low-exposure groups, and those exposed at 31.5 Hz had the highest risk (Adjusted RR=1.97, 95% CI: 1.23, 3.16). Per 5-dB increase in noise frequencies at 31.5, 63, 125, 250, 500 Hz, and 1000 Hz were associated with an elevated incidence of hyperglycemia (all p < 0.05), with the highest risk of 1.27 (95% CI: 1.10, 1.47) at 31.5 Hz (p = 0.001). Conclusions: Exposure to occupational noise may be associated with an increased incidence of hyperglycemia, with the highest risk observed at 31.5 Hz, providing a possible link between noise exposure and cardio-metabolic disease.