Evaluation of the role of thiol / disulfide homeostasis in the etiology of idiopathic male infertility with a novel and automated assay

Objective: Infertility affects 15% of couples in fertile age. Male factor is a cause of infertility in almost half of cases, mainly due to oligoasthenoteratozoospermia (OAT). The purpose of this study is to review the effects of nutritional supplements as medical treatment for idiopathic male infertility. Material and methods: A Pub Med and Medline review of the published studies utilizing nutritional supplements for the treatment of male infertility has been performed. Results: Clinical trials on Vitamin E, Vitamin A, Vitamin C. Arginine, Carnitine, N-Acetyl-Carnitine, Glutathione, Coenzyme Q10, Selenium and Zinc were reviewed. Although there is a wide variability in selected population, dose regimen and final outcomes, nutritional supplements both alone and in combination seems to be able to improve semen parameters (sperm count, sperm motility and morphology) and pregnancy rate in infertile men. Conclusions: There are rising evidences from published randomized trials and systematic review suggesting that nutritional supplementation may improve semen parameters and the likelihood of pregnancy in men affected by OAT. This improvement, however, is not consistent and there is a wide variation in the treatment regimens used. Well designed and adequately powered RCTs are needed to better clarify the role of nutritional supplements as treatment for male infertility.

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1385: Role of Transcription Factors SF-1 and DAX-1 in Steroidogenesis and Spermatogenesis of Idiopathic Male Infertility

The Journal of Urology ◽

10.1016/s0022-5347(18)38610-5 ◽

2004 ◽

Vol 171 (4S) ◽

pp. 365-365

Author(s):

Yoshiyuki Kojima ◽

Shoichi Sasaki ◽

Yutaro Hayashi ◽

Kenjiro Kohri

Keyword(s):

Transcription Factors ◽

Male Infertility ◽

Idiopathic Male Infertility

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Molecular Biology of Spermatogenesis: Novel Targets of Apparently Idiopathic Male Infertility

International Journal of Molecular Sciences ◽

10.3390/ijms21051728 ◽

2020 ◽

Vol 21 (5) ◽

pp. 1728 ◽

Cited By ~ 5

Author(s):

Rossella Cannarella ◽

Rosita A. Condorelli ◽

Laura M. Mongioì ◽

Sandro La Vignera ◽

Aldo E. Calogero

Keyword(s):

Molecular Biology ◽

Male Infertility ◽

Current Evidence ◽

Idiopathic Male Infertility ◽

Oocyte Fertilization ◽

Human Fertilization ◽

Sperm Dna ◽

Infertile Couples ◽

Insight Into

Male infertility affects half of infertile couples and, currently, a relevant percentage of cases of male infertility is considered as idiopathic. Although the male contribution to human fertilization has traditionally been restricted to sperm DNA, current evidence suggest that a relevant number of sperm transcripts and proteins are involved in acrosome reactions, sperm‒oocyte fusion and, once released into the oocyte, embryo growth and development. The aim of this review is to provide updated and comprehensive insight into the molecular biology of spermatogenesis, including evidence on spermatogenetic failure and underlining the role of the sperm-carried molecular factors involved in oocyte fertilization and embryo growth. This represents the first step in the identification of new possible diagnostic and, possibly, therapeutic markers in the field of apparently idiopathic male infertility.

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Role of Kisspeptin Gene Polymorphism in Idiopathic Male Infertility in Iraq

Iraqi Journal of Science ◽

10.24996/ijs.2021.62.10.1 ◽

2021 ◽

pp. 3428-3435

Author(s):

Firas Kareem Al-Kalabi ◽

Adnan F Al-Azzawie ◽

Estabraq AR. Al-Wasiti

Keyword(s):

Male Infertility ◽

Semen Quality ◽

Control Group ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Idiopathic Male Infertility ◽

Polymerase Chain ◽

Infertile Group ◽

Control Study

This case control study aimed to determine single nucleotide polymorphisms (SNPs) in the Kisspeptin (KISS1) gene in males with idiopathic infertility and their association with sex hormones and semen quality. The study included a total of 60 infertile and 30 healthy fertile males. Our results show that the level of the measured hormones (LH, FSH, Testosterone, Prolactin and Kisspeptin-54) were higher in the control group than in the male infertile group at p<0.05. We used polymerase chain reaction restriction fragment length polymorphism (PCR-RELP) for the genotyping of KISS1 position rs35431622 (Q36R) KISS1, which showed three different genotypes of different sizes; a wild-type homozygous AA of 233 bp and a heterozygous AG that has digestion products of 233, 161, and 72 bp. The AG was more frequent in the patients group which also had high OR value of G allele (3.105). While for the rs4889 (C/G(, there was a correlation between the CC genotype and the patients group, but it was non-significant. Patients had an OR value of 2.5 for the CC genotype with 95% CI: 0.21 – 29.26, whereas the OR value for the C allele was 1.14 with 95% CI: 0.613 – 2.135. In conclusion, variations in SNPs of the KISS1 gene may be considered as a risk factor for idiopathic male infertility in Iraqi population.

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Inhibin B and activin A in the pathogenesis of idiopathic male infertility

Kazan medical journal ◽

10.17750/kmj2015-749 ◽

2015 ◽

Vol 96 (5) ◽

pp. 749-752

Author(s):

E F Galimova ◽

G Kh Akhmadullina ◽

K V Bulygin ◽

K S Mochalov ◽

Sh N Galimov

Keyword(s):

Male Infertility ◽

Seminal Fluid ◽

Biological Fluids ◽

Regulatory Peptides ◽

Activin A ◽

Inhibin B ◽

Enzyme Linked Immunosorbent Assay ◽

Reproductive Disorders ◽

Idiopathic Male Infertility

Aim. To assess the role of serum and ejaculate inhibin-activin status disorders in the development of reproductive disorders at idiopathic male infertility. Methods. The research includes data of laboratory and clinical examination of 82 infertile and 60 fertile men. Serum and semen levels of reproduction regulatory peptides inhibin B and activin A were determined using standard commercially available kits for enzyme-linked immunosorbent assay. Other parameters of ejaculate were also investigated. Results. In men with infertility of the unknown cause, sperm cell concentration was significantly decreased, and the proportion of sex cells with morphological anomalies was increased. The main features of inhibin-activin profile of biological fluids in healthy males with proven fertility were revealed, which were the significant gradient of inhibin and activin intertissue concentrations and domination of these molecular fertility factors in seminal plasma, corresponding with the views of their key role in sperm fertilizing capacity. In patients with pathospermia, the significant decrease of inhibin B concentration in the ejaculate but not in serum, associated with increased activin A levels was revealed, accompanied by characteristic shift of inhibin-activin ratio associated with the deterioration of quality and quantity parameters of semen. Conclusion. Revealed changes in the inhibin-activin sperm plasma mirror may be a pathogenetic basis for the idiopathic infertility in couples. Inhibin-activin coefficient in blood serum and seminal fluid may be used as a promising diagnostic and prognostic marker of reproductive dysfunction risk.

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