The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health

Gut microbiota is well known as playing a critical role in inflammation and asthma development. The very low-calorie ketogenic diet (VLCKD) is suggested to affect gut microbiota; however, the effects of VLCKD during pregnancy and lactation on the infant gut microbiota are unclear. The VLCKD appears to be more effective than caloric/energy restriction diets for the treatment of several diseases, such as obesity and diabetes. However, whether adherence to VLCKD affects the infant gut microbiota and the protective effects thereof on asthma remains uncertain. The exact mechanisms underlying this process, and in particular the potential role of short chain fatty acids (SCFAs), are still to be unravelled. Thus, the aim of this review is to identify the potential role of SCFAs that underlie the effects of VLCKD during pregnancy and lactation on the infant gut microbiota, and explore whether it incurs significant implications for reducing asthma.

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The interplay among gut microbiota, hypertension and kidney diseases: The role of short-chain fatty acids

Pharmacological Research ◽

10.1016/j.phrs.2019.01.019 ◽

2019 ◽

Vol 141 ◽

pp. 366-377 ◽

Cited By ~ 16

Author(s):

R.J.F. Felizardo ◽

I. K.M. Watanabe ◽

Patrizia Dardi ◽

L.V. Rossoni ◽

N.O.S. Câmara

Keyword(s):

Fatty Acids ◽

Gut Microbiota ◽

Kidney Diseases ◽

Short Chain Fatty Acids ◽

Short Chain ◽

Chain Fatty Acids

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Faculty Opinions recommendation of Gut microbiota-derived short-chain Fatty acids, T cells, and inflammation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725300895.793509795 ◽

2015 ◽

Author(s):

Jonathan Kaunitz

Keyword(s):

Fatty Acids ◽

T Cells ◽

Gut Microbiota ◽

Short Chain Fatty Acids ◽

Short Chain ◽

Chain Fatty Acids

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The Consumption of Galactomannan Effervescent Drinks made from Coconut Pulp Waste and Colonic Microbiota in Wistar Rats

International Journal of Probiotics and Prebiotics ◽

10.37290/ijpp2641-7197.15:52-56 ◽

2020 ◽

Vol 15 (1) ◽

pp. 52-56

Author(s):

Sri Winarti ◽

Agung Pasetyo

Keyword(s):

Fatty Acids ◽

Gut Microbiota ◽

Wistar Rats ◽

Short Chain Fatty Acids ◽

Short Chain ◽

E Coli ◽

Colonic Microbiota ◽

Male Wistar Rats ◽

Lactobacillus Spp ◽

Chain Fatty Acids

The consumption of prebiotics is known to affect the balance of gut microbiota. The purpose of this study was to explore how a galactomannan-rich effervescent drink can affect the population of Lactobacillus, Bifidobacterium, E. coli, and the concentration of short-chain fatty acids in the cecum of rats. Twenty-eight male Wistar rats (aged 2 months) were divided equally into 7 groups and treated orally each day for 15 days with 2 mL effervescent drinks with increasing levels of prebiotic galactomannan. The dosage of 500 mg galactomannan increased the growth of Lactobacillus spp. and Bifidobacterium spp. with inhibition of the growth of E.coli with increased formation of short-chain fatty acids such as acetate, propionate, and butyrate in the cecum of rats.

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Impact of oral COMT-inhibitors on gut microbiota and short chain fatty acids in Parkinson's disease

Parkinsonism & Related Disorders ◽

10.1016/j.parkreldis.2019.11.020 ◽

2020 ◽

Vol 70 ◽

pp. 20-22 ◽

Cited By ~ 1

Author(s):

Daniel Grün ◽

Valerie C. Zimmer ◽

Jil Kauffmann ◽

Jörg Spiegel ◽

Ulrich Dillmann ◽

...

Keyword(s):

Parkinson’S Disease ◽

Fatty Acids ◽

Parkinson's Disease ◽

Gut Microbiota ◽

Short Chain Fatty Acids ◽

Short Chain ◽

Comt Inhibitors ◽

Chain Fatty Acids

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Glycerol Monocaprylate Modulates Gut Microbiota and Increases Short-Chain Fatty Acids Production without Adverse Effects on Metabolism and Inflammation

Nutrients ◽

10.3390/nu13051427 ◽

2021 ◽

Vol 13 (5) ◽

pp. 1427

Author(s):

Junhui Zhang ◽

Fengqin Feng ◽

Minjie Zhao

Keyword(s):

Fatty Acids ◽

Gut Microbiota ◽

Dose Group ◽

Low Dose ◽

Short Chain Fatty Acids ◽

Normal Diet ◽

Short Chain ◽

High Dose ◽

Dose Treatment ◽

Chain Fatty Acids

Glycerol monocaprylate (GMC) is a glycerol derivative of medium-chain fatty acids (MCFAs) and is widely used as a preservative in food processing. However, GMC and its hydrolytic acid (octylic acid) have antibacterial properties that may affect the physiology and intestinal microecology of the human body. Therefore, in this study, the effects of two different dosages of GMC (150 and 1600 mg kg−1) on glucose, lipid metabolism, inflammation, and intestinal microecology of normal diet-fed C57BL/6 mice were comprehensively investigated. The obtained results showed that the level of triglycerides (TGs) in the low-dose group down-regulated significantly, and the anti-inflammatory cytokine interleukin 10 (IL-10) significantly increased, while the pro-inflammatory cytokines monocyte chemotactic protein 1 (MCP-1) and interleukin 1beta (IL-1β) in the high-dose group were significantly decreased. Importantly, GMC promoted the α-diversity of gut microbiota in normal-diet-fed mice, regardless of dosages. Additionally, it was found that the low-dose treatment of GMC significantly increased the abundance of Lactobacillus, while the high-dose treatment of GMC significantly increased the abundance of SCFA-producers such as Clostridiales, Lachnospiraceae, and Ruminococcus. Moreover, the content of short-chain fatty acids (SCFAs) was significantly increased by GMC supplementation. Thus, our research provides a novel insight into the effects of GMC on gut microbiota and physiological characteristics.

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