scholarly journals Public health and economic impact of seasonal influenza vaccination with quadrivalent influenza vaccines compared to trivalent influenza vaccines in Europe

2016 ◽  
Vol 12 (9) ◽  
pp. 2259-2268 ◽  
Author(s):  
Mathieu Uhart ◽  
Hélène Bricout ◽  
Emilie Clay ◽  
Nathalie Largeron
Keyword(s):  
Public Health ◽  
Influenza Vaccination ◽  
Economic Impact ◽  
Seasonal Influenza ◽  
Influenza Vaccines ◽  
Seasonal Influenza Vaccination

scholarly journals Influenza vaccination campaigns targeted at healthcare workers:results of four hospitals in Rome

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
A Tognetto ◽  
A Abbondanzieri ◽  
G Cerone ◽  
M Di Pumpo ◽  
A Nardi ◽  
...  
Keyword(s):  
Public Health ◽  
Influenza Vaccination ◽  
Vaccination Coverage ◽  
Seasonal Influenza ◽  
Teaching Hospitals ◽  
Easy Access ◽  
Cross Sectional ◽  
Seasonal Influenza Vaccination ◽  
Coverage Rates ◽  
Vaccination Campaigns

Abstract Background Seasonal influenza vaccination (SIV) of health care workers (HCWs) is well recognized as a public health measure that can protect both HCWs from infection and patients from the risk of influenza complications. Nevertheless, vaccination coverage rates among this specific population result generally lower than the recommended target. With our study, we aimed to describe the activities and the outcomes of four different SIV campaigns targeted at HCWs and organized during the season 2018/2019 in four hospitals in Rome. Methods A cross-sectional study involving four teaching hospitals was performed. The collected data were synthetized into a set of descriptors and indicators, validated through a previous study that had involved the same Centers. Results The Medical Directorates, in collaboration with the University Hygiene and Public Health Units of the four hospitals organized different strategies: Hospital 1, 3 and 4 realized educational courses for HCWs and actively promoted the campaigns through e-mail invitations to all HCWs. As for the access to vaccination, all the hospitals provided a dedicated unit for SIV; Hospital 1 and Hospital 4 organized also on-site vaccination sessions in the hospital wards, that required a large number of staff. The vaccination coverage rates resulted: 22.37% in Hospital 1, 18.10% in Hospital 4, 9.28% in Hospital 2 and 8,51% in Hospital 3. Conclusions Our results demonstrate that multi-activity campaigns, involving education, promotion and easy access to vaccination constitute an effective approach to reinforce the value of SIV. Our findings suggest that on-site vaccination may play a key role in determining a higher vaccination coverage. Key messages Multi-activity vaccination campaigns, involving education, promotion and easy access to vaccination constitute an effective approach to reinforce the value of seasonal influenza vaccination for HCWs. On-site vaccination may play a key role in determining a higher vaccination coverage.

scholarly journals Annual public health and economic benefits of seasonal influenza vaccination: a European estimate

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Emmanuelle Preaud ◽  
Laure Durand ◽  
Bérengère Macabeo ◽  
Norbert Farkas ◽  
Brigitte Sloesen ◽  
...  
Keyword(s):  
Public Health ◽  
Influenza Vaccination ◽  
Seasonal Influenza ◽  
Economic Benefits ◽  
Seasonal Influenza Vaccination

scholarly journals Heterotypic Neuraminidase Antibodies Against Different A(H1N1) Strains are Elicited after Seasonal Influenza Vaccination

Vaccines ◽  
2019 ◽  
Vol 7 (1) ◽  
pp. 30 ◽  
Author(s):  
Jose Mendez-Legaza ◽  
Raúl Ortiz de Lejarazu ◽  
Ivan Sanz
Keyword(s):  
Immune Response ◽  
Influenza Vaccination ◽  
Seasonal Influenza ◽  
Geometric Mean ◽  
Age Groups ◽  
Influenza Vaccines ◽  
Serum Samples ◽  
Seasonal Influenza Vaccination ◽  
Before And After ◽  
Original Antigenic Sin

Neuraminidase (NA) content is not standardized in current seasonal influenza vaccines; neither anti-NA antibodies (anti-NA Abs) are measured nor is it well-defined as a correlate of humoral protection. In this work, the presence of NA1 antibodies against classical A(H1N1) and A(H1N1) pdm09 subtypes was studied before and after vaccination with seasonal vaccines containing A/California/07/2009 strain (A(H1N1) pdm09 subtype). By Enzyme-Linked Lectin Assay (ELLA; Consortium for the Standardization of Influenza Seroepidemiology), we analyzed serum samples from two different cohorts (adults and elderly). The presence of anti-NA Abs at titers ≥1/40 against classical A(H1N1) and A(H1N1) pdm09 subtypes were frequently found in both age groups, in 81.3% and 96.3% of adults and elderly, respectively. The higher titers of anti-NA Abs (NAI titers) were detected more frequently against classical A(H1N1) strains according to the expected age when the first flu infection takes place. In this way, an Original Antigenic Sin phenomenon related to NA seems to be part of the immune response against flu. Seasonal-vaccination induced homologous seroconversion against NA of A(H1N1) pdm09 subtype in 52.5% and 55.0%, and increased the Geometric Mean Titers (GMTs) in 70.0% and 78.8% of adults and elderly, respectively. Seasonal vaccination also induced a heterotypic anti-NA Abs response against classical A(H1N1) strains (seroconversion at least in 8.8% and 11.3% of adults and elderly, respectively, and an increase in GMTs of at least 28.0% in both age groups). These anti-NA Abs responses occur even though the seasonal vaccine does not contain a standardized amount of NA. This work demonstrates that seasonal vaccines containing the A(H1N1) pdm09 subtype induce a broad antibody response against NA1, that may be a target for future influenza vaccines. Our study is one of the first to analyze the presence of Abs against NA and the response mediated by NAI titers after seasonal influenza vaccination.

Health and economic impact of the seasonal influenza vaccination programme in England

Vaccine ◽  
2012 ◽  
Vol 30 (23) ◽  
pp. 3459-3462 ◽  
Author(s):  
Marc Baguelin ◽  
Mark Jit ◽  
Elizabeth Miller ◽  
William John Edmunds
Keyword(s):  
Influenza Vaccination ◽  
Economic Impact ◽  
Vaccination Programme ◽  
Seasonal Influenza ◽  
Seasonal Influenza Vaccination

scholarly journals Impact of national influenza vaccination strategy in severe influenza outcomes among the high-risk Portuguese population

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Ausenda Machado ◽  
Irina Kislaya ◽  
Amparo Larrauri ◽  
Carlos Matias Dias ◽  
Baltazar Nunes
Keyword(s):  
High Risk ◽  
Influenza Vaccination ◽  
Seasonal Influenza ◽  
Vaccine Coverage ◽  
Vaccination Strategy ◽  
High Risk Population ◽  
Risk Population ◽  
Seasonal Influenza Vaccination ◽  
Severe Influenza ◽  
The Impact

Abstract Background All aged individuals with a chronic condition and those with 65 and more years are at increased risk of severe influenza post-infection complications. There is limited research on cases averted by the yearly vaccination programs in high-risk individuals. The objective was to estimate the impact of trivalent seasonal influenza vaccination on averted hospitalizations and death among the high-risk population in Portugal. Methods The impact of trivalent seasonal influenza vaccination was estimated using vaccine coverage, vaccine effectiveness and the number of influenza-related hospitalizations and deaths. The number of averted events (NAE), prevented fraction (PF) and number needed to vaccinate (NVN) were estimated for seasons 2014/15 to 2016/17. Results The vaccination strategy averted on average approximately 1833 hospitalizations and 383 deaths per season. Highest NAE was observed in the ≥65 years population (85% of hospitalizations and 95% deaths) and in the 2016/17 season (1957 hospitalizations and 439 deaths). On average, seasonal vaccination prevented 21% of hospitalizations in the population aged 65 and more, and 18.5% in the population with chronic conditions. The vaccination also prevented 29% and 19.5% of deaths in each group of the high-risk population. It would be needed to vaccinate 3360 high-risk individuals, to prevent one hospitalization and 60,471 high-risk individuals to prevent one death. Conclusion The yearly influenza vaccination campaigns had a sustained positive benefit for the high-risk population, reducing hospitalizations and deaths. These results can support public health plans toward increased vaccine coverage in high-risk groups.

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