scholarly journals Vaccination among HIV-infected, HIV-exposed uninfected and HIV-uninfected children: a systematic review and meta-analysis of evidence related to vaccine efficacy and effectiveness

2019 ◽  
Vol 15 (11) ◽  
pp. 2578-2589 ◽  
Author(s):  
Olatunji O. Adetokunboh ◽  
Duduzile Ndwandwe ◽  
Ajibola Awotiwon ◽  
Olalekan A. Uthman ◽  
Charles S. Wiysonge
Keyword(s):  
Systematic Review ◽  
Vaccine Efficacy ◽  
Meta Analysis ◽  
Hiv Exposed ◽  
Exposed Uninfected

scholarly journals Effect of in utero exposure to HIV and antiretroviral drugs on growth in HIV-exposed uninfected children: a systematic review and meta-analysis protocol

BMJ Open ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. e023937 ◽  
Author(s):  
Gabriel L Ekali ◽  
Julie Jesson ◽  
Pascal B Enok ◽  
Valériane Leroy
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
In Utero ◽  
Antiretroviral Drugs ◽  
Morbidity And Mortality ◽  
Cochrane Library ◽  
Growth Disorders ◽  
Growth Impairment ◽  
Hiv Exposed ◽  
Exposed Uninfected

IntroductionHIV-exposed uninfected (HEU) children have higher morbidity and mortality compared with HIV unexposed uninfected children. Despite the fact that malnutrition contributes to about half of all infant deaths below 5 years of age in low-income and middle-income countries and that growth impairment has been reported in the HEU population, the spectrum of growth disorders associated with HIV and antiretroviral therapy (ART) exposure during the in utero and perinatal periods is yet to comprehensively summarised among the global HEU population. This protocol for a systematic review and meta-analysis aims to critically synthesise data concerning the prevalence of underweight, stunting and wasting at different ages in the global HEU population.Methods and analysisMedline, EMBASE, Cochrane Library, TOXLINE, WHO Global Index Medicus and the Web of Science will be searched for relevant articles published between 1 January 1989 and 1 December 2017 without language restriction. In addition, conference abstracts and reference lists of eligible papers and relevant review articles will be screened. Authors will screen and select studies, extract data, assess the risk of bias as well as studies individually for heterogeneity. Study-specific estimates will be pooled through a random-effects meta-analysis model for studies that are clinically homogeneous while funnel plots and Egger’s test will be used to detect publication bias. Results will be presented by ART availability period, country income levels and mode of breastfeeding.Ethics and disseminationEthical approval will not be required for this study because it will be based on published data. The final report of this study will be published in a peer-reviewed journal and presented at scientific conferences. This review will summarise the evidence and quantify the problem of growth impairment in HEU infants and so shed more light on our understanding of the higher morbidity and mortality in this growing population.PROSPERO registration numberCRD42018091762.

scholarly journals Safety and Immunogenicity of Measles Vaccination in HIV-Infected and HIV-Exposed Uninfected Children: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 1 ◽  
pp. 28-42 ◽  
Author(s):  
Eleonora A.M.L. Mutsaerts ◽  
Marta C. Nunes ◽  
Martijn N. van Rijswijk ◽  
Kerstin Klipstein-Grobusch ◽  
Diederick E. Grobbee ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Measles Vaccination ◽  
Hiv Exposed ◽  
Exposed Uninfected

A meta-analysis assessing all-cause mortality in HIV-exposed uninfected compared with HIV-unexposed uninfected infants and children

AIDS ◽  
2016 ◽  
Vol 30 (15) ◽  
pp. 2351-2360 ◽  
Author(s):  
Alana T. Brennan ◽  
Rachael Bonawitz ◽  
Christopher J. Gill ◽  
Donald M. Thea ◽  
Mary Kleinman ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Infants And Children ◽  
All Cause Mortality ◽  
Hiv Exposed ◽  
Exposed Uninfected

Influenza Vaccine Efficacy and Effectiveness in Pregnant Women: Systematic Review and Meta-analysis

2019 ◽  
Vol 24 (2) ◽  
pp. 229-240 ◽  
Author(s):  
Trang Ho Thu Quach ◽  
Nicholas Alexander Mallis ◽  
José F. Cordero
Keyword(s):  
Systematic Review ◽  
Influenza Vaccine ◽  
Pregnant Women ◽  
Vaccine Efficacy ◽  
Meta Analysis

scholarly journals Mobile phone communication for improving uptake of antiretroviral therapy in HIV-infected pregnant women: updated systematic review and meta-analysis

2021 ◽  
Author(s):  
Jacques L. Tamuzi ◽  
Gomer Lulendo ◽  
Patrick Mbuesse ◽  
Thierry Ntambwe
Keyword(s):  
Systematic Review ◽  
Mobile Phone ◽  
Pregnant Women ◽  
Hiv Testing ◽  
Text Messaging ◽  
Post Partum ◽  
Meta Analysis ◽  
Cochrane Central Register ◽  
Hiv Exposed ◽  
Mobile Phone Communication

Objective The aim of this systematic review is to provide some evidence on the use of mobile phone communication for improving ARV adherence during pregnancy, as well as to investigate whether text messaging on mobile phones could improve follow up in HIV exposed infants. Methods We did a systematic review and meta-analysis, using CENTRAL (Cochrane Central Register of Controlled Trials), Scopus, MEDLINE via PubMed, Web of Science, and CINAHL to search for studies in English published between 5 may 2016 to May 2021 that assessed the effects of mobile phone in HIV infected pregnant women. We used MetaPro version 3.0 to compute the OR 2 and RR and their 95%CI. We performed random-effects model meta analysis for estimating pooled outcomes. Results Nine studies were included in the meta-analysis. The pooled maternal postpartum retention was (OR 2.20, 95%CI: 1.55 to 3.13, I2 = 53.20%, P < 0.001). In the same line, the pooled odds of ART uptake was (OR 1.5, 95%CI: 1.07 to 2.11, I2 =0%, P = 0.020) and we found statistically significant impact of mobile phone on HIV testing at 6 weeks and above among HIV exposed children (OR 1.89, 95%CI: 1.04 to 3. 48, I2 = OR 1.89, 95%CI: 1.04 to 3. 48, I2 =88.04%, P = 0.032). Conclusion In comparison to our previous review, this updated review focuses on moderate evidence for mobile phone communication in HIV-infected pregnant women. The results showed that using a mobile phone improved maternal post-partum retention, ART uptake, and infant HIV testing at 6 weeks and older.

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