Progress of titanium strut for cervical reconstruction with nano-graphene oxide loaded hydroxyapatite/polyamide composite and interbody fusion after corpectomy with anterior plate fixation

Object An interspinous anchor (ISA) provides fixation to the lumbar spine to facilitate fusion. The biomechanical stability provided by the Aspen ISA was studied in applications utilizing an anterior lumbar interbody fusion (ALIF) construct. Methods Seven human cadaveric L3–S1 specimens were tested in the following states: 1) intact; 2) after placing an ISA at L4–5; 3) after ALIF with an ISA; 4) after ALIF with an ISA and anterior screw/plate fixation system; 5) after removing the ISA (ALIF with plate only); 6) after removing the plate (ALIF only); and 7) after applying bilateral pedicle screws and rods. Pure moments (7.5 Nm maximum) were applied in flexion and extension, lateral bending, and axial rotation while recording angular motion optoelectronically. Changes in angulation as well as foraminal height were also measured. Results All instrumentation variances except ALIF alone reduced angular range of motion (ROM) significantly from normal in all directions of loading. The ISA was most effective in limiting flexion and extension (25% of normal) and less effective in reducing lateral bending (71% of normal) and axial rotation (71% of normal). Overall, ALIF with an ISA provided stability that was statistically equivalent to ALIF with bilateral pedicle screws and rods. An ISA-augmented ALIF allowed less ROM than plate-augmented ALIF during flexion, extension, and lateral bending. Use of the ISA resulted in flexion at the index level, with a resultant increase in foraminal height. Compensatory extension at the adjacent levels prevented any significant change in overall sagittal balance. Conclusions When used with ALIF at L4–5, the ISA provides immediate rigid immobilization of the lumbar spine, allowing equivalent ROM to that of a pedicle screw/rod system, and smaller ROM than an anterior plate. When used with ALIF, the ISA may offer an alternative to anterior plate fixation or bilateral pedicle screw/rod constructs.

Download Full-text

Outcomes of stand-alone anterior lumbar interbody fusion of L5–S1 using a novel implant with anterior plate fixation

The Spine Journal ◽

10.1016/j.spinee.2020.05.555 ◽

2020 ◽

Vol 20 (10) ◽

pp. 1618-1628

Author(s):

Marc Szadkowski ◽

Henri d'Astorg ◽

Haroun Bouhali ◽

Ivan Aleksic ◽

Sonia Ramos-Pascual ◽

...

Keyword(s):

Interbody Fusion ◽

Plate Fixation ◽

Anterior Lumbar Interbody Fusion ◽

Lumbar Interbody Fusion ◽

Anterior Plate

Download Full-text

In vitro biomechanical comparison of an anterior and anterolateral lumbar plate with posterior fixation following single-level anterior lumbar interbody fusion

Journal of Neurosurgery Spine ◽

10.3171/spi-07/09/332 ◽

2007 ◽

Vol 7 (3) ◽

pp. 332-335 ◽

Cited By ~ 11

Author(s):

Wesley M. Johnson ◽

Tann A. Nichols ◽

Deepika Jethwani ◽

Bernard H. Guiot

Keyword(s):

Interbody Fusion ◽

Plate Fixation ◽

Anterior Lumbar Interbody Fusion ◽

Posterior Fixation ◽

Lumbar Interbody Fusion ◽

Lateral Bending ◽

Anterior Plate ◽

Axial Torsion ◽

Flexion Extension

Object Anterior lumbar interbody fusion (ALIF) is often supplemented with instrumentation to increase stability in the spine. If anterior plate fixation provided the same stability as posterior pedicle screw fixation (PSF), then a second approach and its associated morbidity could be avoided. Methods Seven human cadaveric L4–5 spinal segments were tested under three conditions: ALIF with an anterior plate, ALIF with an anterolateral plate, and ALIF supplemented by PSF. Range of motion (ROM) was calculated for flexion/extension, lateral bending, and axial torsion and compared among the three configurations. Results There were no significant differences in ROM during flexion/extension, lateral bending, or axial torsion among any of the three instrumentation configurations. Conclusions The addition of an anterior plate or posterior PS/rod instrumentation following ALIF provides substantially equivalent biomechanical stability. Additionally, the position of the plate system, either anterior or anterolateral, does not significantly affect the stability gained.

Download Full-text

Functionalized Nano-graphene Oxide as Multi-modal Clinic for Effective Drug Delivery

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2017.10.4.3 ◽

2017 ◽

Vol 10 (4) ◽

pp. 3768-3771

Author(s):

Soumitra Satapathi ◽

Rutusmita Mishra ◽

Manisha Chatterjee ◽

Partha Roy ◽

Somesh Mohapatra

Keyword(s):

Drug Delivery ◽

Graphene Oxide ◽

Cancer Cell ◽

High Surface ◽

High Surface Area ◽

Cancer Cell Line ◽

Xrd Analysis ◽

Graphene Derivatives ◽

Nano Graphene

Nano-materials based drug delivery modalities to specific organs and tissues has become one of the critical endeavors in pharmaceutical research. Recently, two-dimensional graphene has elicited considerable research interest because of its potential application in drug delivery systems. Here we report, the drug delivery applications of PEGylated nano-graphene oxide (nGO-PEG), complexed with a multiphoton active and anti-cancerous diarylheptanoid drug curcumin. Specifically, graphene-derivatives were used as nanovectors for the delivery of the hydrophobic anticancer drug curcumin due to its high surface area and easy surface functionalization. nGO was synthesized by modified Hummer’s method and confirmed by XRD analysis. The formation of nGO, nGO-PEG and nGO-PEG-Curcumin complex were monitored through UV-vis, IR spectroscopy. MTT assay and AO/EB staining found that nGO-PEG-Curcumin complex afforded highly potent cancer cell killing in vitro with a human breast cancer cell line MCF7.

Download Full-text