THE PATHOLOGIC EFFECTS OF INTRAVENOUSLY ADMINISTERED SOLUBLE ANTIGEN-ANTIBODY COMPLEXES

The intravenous administration to rats of soluble antigen-antibody complexes in antigen excess resulted in acute glomerulonephritis. This occurred with both rabbit antiovalbumin and rabbit anti-BSA systems. The rats so treated regularly showed proteinuria and elevation of blood urea nitrogen. These findings are compared with those reported in rats injected with anti-kidney serum.

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Production of Acute Glomerulonephritis in Mice with Soluble Antigen-Antibody Complexes Prepared from Homologous Antibody.

Experimental Biology and Medicine ◽

10.3181/00379727-104-25960 ◽

1960 ◽

Vol 104 (4) ◽

pp. 706-709 ◽

Cited By ~ 9

Author(s):

F. Miller ◽

B. Benacerraf ◽

R. T. McCluskey ◽

J. L. Potter

Keyword(s):

Acute Glomerulonephritis ◽

Soluble Antigen ◽

Antigen Antibody

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622 Blood urea nitrogen — an important prognostic marker in patients with chronic heart failure

European Journal of Heart Failure Supplements ◽

10.1016/s1567-4215(06)80419-4 ◽

2006 ◽

Vol 5 (1) ◽

pp. 145-146

Author(s):

M ROIK ◽

M STARCZEWSKA ◽

S STAWICKI ◽

Z HUCZEK ◽

J KOCHANOWSKI ◽

...

Keyword(s):

Heart Failure ◽

Chronic Heart Failure ◽

Prognostic Marker ◽

Blood Urea Nitrogen ◽

Urea Nitrogen

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Association between Blood Urea Nitrogen-to-creatinine Ratio and Three-Month Outcome in Patients with Acute Ischemic Stroke

Current Neurovascular Research ◽

10.2174/1567202616666190412123705 ◽

2019 ◽

Vol 16 (2) ◽

pp. 166-172 ◽

Cited By ~ 1

Author(s):

Linghui Deng ◽

Changyi Wang ◽

Shi Qiu ◽

Haiyang Bian ◽

Lu Wang ◽

...

Keyword(s):

Logistic Regression ◽

Ischemic Stroke ◽

Clinical Outcome ◽

Acute Ischemic Stroke ◽

Blood Urea Nitrogen ◽

Univariate Analysis ◽

Density Lipoprotein ◽

Hydration Status ◽

Creatinine Ratio ◽

Urea Nitrogen

Background: Hydration status significantly affects the clinical outcome of acute ischemic stroke (AIS) patients. Blood urea nitrogen-to-creatinine ratio (BUN/Cr) is a biomarker of hydration status. However, it is not known whether there is a relationship between BUN/Cr and three-month outcome as assessed by the modified Rankin Scale (mRS) score in AIS patients. Methods: AIS patients admitted to West China Hospital from 2012 to 2016 were prospectively and consecutively enrolled and baseline data were collected. Poor clinical outcome was defined as three-month mRS > 2. Univariate and multivariate logistic regression analyses were performed to determine the relationship between BUN/Cr and three-month outcome. Confounding factors were identified by univariate analysis. Stratified logistic regression analysis was performed to identify effect modifiers. Results: A total of 1738 patients were included in the study. BUN/Cr showed a positive correlation with the three-month outcome (OR 1.02, 95% CI 1.00-1.03, p=0.04). However, after adjusting for potential confounders, the correlation was no longer significant (p=0.95). An interaction between BUN/Cr and high-density lipoprotein (HDL) was discovered (p=0.03), with a significant correlation between BUN/Cr and three-month outcome in patients with higher HDL (OR 1.03, 95% CI 1.00-1.07, p=0.04). Conclusion: Elevated BUN/Cr is associated with poor three-month outcome in AIS patients with high HDL levels.

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Theaflavin Enriched Black Tea Extract Alleviates Diabetic Nephropathy by Suppressing Hyperglycaemia-Mediated Oxidative Stress and Inflammation in Streptozotocin-Induced Rats

The Natural Products Journal ◽

10.2174/2210315510999200607182700 ◽

2020 ◽

Vol 10 ◽

Author(s):

Dhrubajyoti Sarkar ◽

Sekhar Kumar Bose ◽

Tania Chakraborty ◽

Souvik Roy

Keyword(s):

Oxidative Stress ◽

Diabetic Nephropathy ◽

Blood Glucose ◽

Blood Urea Nitrogen ◽

Phenolic Content ◽

Black Tea ◽

Total Phenolic ◽

Urea Nitrogen ◽

Black Tea Extract ◽

Tea Extract

Background: Diabetic nephropathy (DN), a microvascular complication of diabetes has been a significant health issue globally. However, theaflavin enriched black tea extract (BTE-TF) could restrain DN. Objective: The main objective of this exploration was to elucidate the effect of BTE-TF on DN, though the underlying mechanism remains unclear and requires further investigation. Method: The tea leaves were fermented to get black tea extract. Total phenolic content and HPLC were carried out to determine the phenolic content and theaflavin in the extract. Streptozotocin induced diabetic rats were treated with 100, 200, and 400 mg/kg/day BTE-TF extract for 12 weeks. Biochemical parameters like blood glucose, creatinine, blood urea nitrogen (BUN), triglyceride and antioxidant parameters of kidney tissue were measured. Histology, immunohistochemistry and TUNEL assay were performed to observe the effect of the extract with comparison to the standard drug (Metformin 200mg/kg/day). Result: Treated animals exhibited reduced blood glucose levels, blood urea nitrogen (BUN), creatinine, and serum triglycerides. Further, BTE-TF restored the histological alterations in the kidney. Chronic hyperglycaemia resulted in a significant increase in oxidative stress and pro-inflammatory cytokines of NF-kβ pathway. BTE-TF attenuated oxidative stress (p<0.01), inflammation (p<0.05) and apoptosis (p<0.05). Conclusion: This study suggests that BTE-TF exerts a protective role against diabetes-induced renal injury by ameliorating oxidative stress, inflammation, and apoptosis.

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