The Plasmodium circumsporozoite protein is proteolytically processed during cell invasion
2005 ◽
Vol 201
(1)
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pp. 27-33
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Keyword(s):
The circumsporozoite protein (CSP) is the major surface protein of Plasmodium sporozoites, the infective stage of malaria. Although CSP has been extensively studied as a malaria vaccine candidate, little is known about its structure. Here, we show that CSP is proteolytically cleaved by a papain family cysteine protease of parasite origin. Our data suggest that the highly conserved region I, found just before the repeat region, contains the cleavage site. Cleavage occurs on the sporozoite surface when parasites contact target cells. Inhibitors of CSP processing inhibit cell invasion in vitro, and treatment of mice with E-64, a highly specific cysteine protease inhibitor, completely inhibits sporozoite infectivity in vivo.
The Plasmodium falciparum circumsporozoite protein produced in Lactococcus lactis is pure and stable
2019 ◽
Vol 295
(2)
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pp. 403-414
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Keyword(s):
2001 ◽
Vol 69
(12)
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pp. 7380-7386
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2006 ◽
Vol 50
(5)
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pp. 1731-1737
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Keyword(s):
Keyword(s):
2018 ◽
Vol 9
(1)
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pp. 4-11
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Keyword(s):