CICATRIZATION OF WOUNDS

The cicatrization of sterile wounds may be studied in the same way as an ordinary physicochemical phenomenon. It is possible, therefore, to express the law of cicatrization by a mathematical equation as soon as an accurate measure of the wound can be obtained. By means of the equation, a curve is obtained which represents the theoretical evolution of the cicatrization of a wound. This curve, being an expression of what should happen on a normal wound, healing aseptically, on a normal man, is a daily point of comparison to what appears actually on the observed wound, and allows one to study accurately the fluctuations of cicatrization on a given individual, and the action of different dressings and antiseptic substances

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The lysosomal trafficking regulator is necessary for normal wound healing

Wound Repair and Regeneration ◽

10.1111/wrr.12984 ◽

2021 ◽

Author(s):

Jacob C. Zbinden ◽

Gabriel J. M. Mirhaidari ◽

Kevin M. Blum ◽

Andrew J. Musgrave ◽

James W. Reinhardt ◽

...

Keyword(s):

Wound Healing ◽

Lysosomal Trafficking ◽

Normal Wound Healing

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Xanthine Oxidoreductase Function Contributes to Normal Wound Healing

Molecular Medicine ◽

10.2119/molmed.2014.00191 ◽

2015 ◽

Vol 21 (1) ◽

pp. 313-322 ◽

Cited By ~ 10

Author(s):

Michael C. Madigan ◽

Ryan M. McEnaney ◽

Ankur J. Shukla ◽

Guiying Hong ◽

Eric E. Kelley ◽

...

Keyword(s):

Wound Healing ◽

Xanthine Oxidoreductase ◽

Normal Wound Healing

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Single layer suturing in intracapsular myomectomy of intramural myomas is sufficient for a normal wound healing

European Journal of Obstetrics & Gynecology and Reproductive Biology ◽

10.1016/j.ejogrb.2020.03.042 ◽

2020 ◽

Vol 248 ◽

pp. 204-210

Author(s):

Yannis Prapas ◽

Athanasios Zikopoulos ◽

Stamatios Petousis ◽

Panayotis Xiromeritis ◽

Andrea Tinelli ◽

...

Keyword(s):

Wound Healing ◽

Single Layer ◽

Normal Wound Healing

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Functional Mining of the Crotalus Spp. Venom Protease Repertoire Reveals Potential for Chronic Wound Therapeutics

Molecules ◽

10.3390/molecules25153401 ◽

2020 ◽

Vol 25 (15) ◽

pp. 3401

Author(s):

David Meléndez-Martínez ◽

Luis Fernando Plenge-Tellechea ◽

Ana Gatica-Colima ◽

Martha Sandra Cruz-Pérez ◽

José Manuel Aguilar-Yáñez ◽

...

Keyword(s):

Wound Healing ◽

Serine Proteases ◽

Chronic Wounds ◽

Chronic Wound ◽

Healing Process ◽

Wound Healing Process ◽

Major Health Problem ◽

Normal Wound Healing ◽

Alternative Sources ◽

Fibrin Clots

Chronic wounds are a major health problem that cause millions of dollars in expenses every year. Among all the treatments used, active wound treatments such as enzymatic treatments represent a cheaper and specific option with a fast growth category in the market. In particular, bacterial and plant proteases have been employed due to their homology to human proteases, which drive the normal wound healing process. However, the use of these proteases has demonstrated results with low reproducibility. Therefore, alternative sources of proteases such as snake venom have been proposed. Here, we performed a functional mining of proteases from rattlesnakes (Crotalus ornatus, C. molossus nigrescens, C. scutulatus, and C. atrox) due to their high protease predominance and similarity to native proteases. To characterize Crotalus spp. Proteases, we performed different protease assays to measure and confirm the presence of metalloproteases and serine proteases, such as the universal protease assay and zymography, using several substrates such as gelatin, casein, hemoglobin, L-TAME, fibrinogen, and fibrin. We found that all our venom extracts degraded casein, gelatin, L-TAME, fibrinogen, and fibrin, but not hemoglobin. Crotalus ornatus and C. m. nigrescens extracts were the most proteolytic venoms among the samples. Particularly, C. ornatus predominantly possessed low molecular weight proteases (P-I metalloproteases). Our results demonstrated the presence of metalloproteases capable of degrading gelatin (a collagen derivative) and fibrin clots, whereas serine proteases were capable of degrading fibrinogen-generating fibrin clots, mimicking thrombin activity. Moreover, we demonstrated that Crotalus spp. are a valuable source of proteases that can aid chronic wound-healing treatments.

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Suppressor cell generation during normal wound healing

Journal of Surgical Research ◽

10.1016/0022-4804(88)90173-4 ◽

1988 ◽

Vol 44 (4) ◽

pp. 321-325 ◽

Cited By ~ 5

Author(s):

Robert J. Breslin ◽

Hannah L. Wasserkrug ◽

Gershon Efron ◽

Adrian Barbul

Keyword(s):

Wound Healing ◽

Suppressor Cell ◽

Cell Generation ◽

Normal Wound Healing

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From Grafts to Human Bioengineered Vascularized Skin Substitutes

International Journal of Molecular Sciences ◽

10.3390/ijms21218197 ◽

2020 ◽

Vol 21 (21) ◽

pp. 8197

Author(s):

Wasima Oualla-Bachiri ◽

Ana Fernández-González ◽

María I. Quiñones-Vico ◽

Salvador Arias-Santiago

Keyword(s):

Tissue Engineering ◽

Wound Healing ◽

Chronic Wounds ◽

Thermal Regulation ◽

Skin Substitute ◽

Skin Substitutes ◽

Normal Wound Healing ◽

Physiological Homeostasis ◽

Promising Solution ◽

Native Skin

The skin plays an important role in the maintenance of the human’s body physiological homeostasis. It acts as a coverage that protects against infective microorganism or biomechanical impacts. Skin is also implied in thermal regulation and fluid balance. However, skin can suffer several damages that impede normal wound-healing responses and lead to chronic wounds. Since the use of autografts, allografts, and xenografts present source limitations and intense rejection associated problems, bioengineered artificial skin substitutes (BASS) have emerged as a promising solution to address these problems. Despite this, currently available skin substitutes have many drawbacks, and an ideal skin substitute has not been developed yet. The advances that have been produced on tissue engineering techniques have enabled improving and developing new arising skin substitutes. The aim of this review is to outline these advances, including commercially available skin substitutes, to finally focus on future tissue engineering perspectives leading to the creation of autologous prevascularized skin equivalents with a hypodermal-like layer to achieve an exemplary skin substitute that fulfills all the biological characteristics of native skin and contributes to wound healing.

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Viral Infections and Wounds

Canadian Journal of Plastic Surgery ◽

10.1177/229255039800600309 ◽

1998 ◽

Vol 6 (3) ◽

pp. 159-161 ◽

Cited By ~ 1

Author(s):

Naznin Karsan ◽

Ronald M Zuker

Keyword(s):

Wound Healing ◽

Case Report ◽

Detrimental Effect ◽

Viral Infections ◽

Healing Process ◽

Wound Healing Process ◽

Normal Wound Healing

The effects of viral infections on normal wound healing are discussed. The case report presented suggests that viruses can have a detrimental effect on the normal wound healing process.

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Role of Nitric Oxide in Wound Healing

Biological Research For Nursing ◽

10.1177/1099800402004001002 ◽

2002 ◽

Vol 4 (1) ◽

pp. 5-15 ◽

Cited By ~ 26

Author(s):

Beverly B. Childress ◽

Joyce K. Stechmiller

Keyword(s):

Nitric Oxide ◽

Wound Healing ◽

Growth Factors ◽

Animal Studies ◽

Chronic Wounds ◽

Current Knowledge ◽

Wound Care ◽

Impaired Wound Healing ◽

Normal Wound Healing ◽

Age Related

Chronic wounds mainly affect elderly individuals and persons with comorbid diseases due to a compromised immune status. An age-related decline in immune function deters proper healing of wounds in an orderly and timely manner. Thus, older adults with 1 or more concomitant illnesses are more likely to experience and suffer from a nonhealing wound, which may drastically decrease their quality of life and financial resources. Novel therapies in wound care management rely heavily on our current knowledge of wound healing physiology. It is well established that normal wound healing occurs sequentially and is strictly regulated by pro-inflammatory cytokines and growth factors. A multitude of commercial products such as growth factors are available; however, their effectiveness in healing chronic wounds has yet to be proven. Recently, investigators have implicated nitric oxide (NO) in the exertion of regulatory forces on various cellular activities of the inflammatory and proliferative phases of wound healing. Gene therapy in animal studies has shown promising results and is furthering our understanding of impaired wound healing. The purpose of this article is to review the literature on NO and its role in wound healing. A discussion of the physiology of normal healing and the pathophysiology of chronic wounds is provided.

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