scholarly journals Nadir CD4+ T Cell Count Predicts Response to Subcutaneous Recombinant Interleukin-2

2003 ◽  
Vol 37 (8) ◽  
pp. e115-e120 ◽  
Author(s):  
N. Markowitz ◽  
J. D. Bebchuk ◽  
D. I. Abrams ◽  
Keyword(s):  
T Cell ◽  
Cell Count ◽  
Interleukin 2 ◽  
Cd4 T Cell ◽  
Recombinant Interleukin 2 ◽  
Cd4 T Cell Count

scholarly journals CD4 T Cell Survival after Intermittent Interleukin‐2 Therapy Is Predictive of an Increase in the CD4 T Cell Count of HIV‐Infected Patients

2008 ◽  
Vol 198 (6) ◽  
pp. 843-850 ◽  
Author(s):  
Sarah W. Read ◽  
Richard A. Lempicki ◽  
Michele Di Mascio ◽  
Sharat Srinivasula ◽  
Rosanne Burke ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Survival ◽  
Cell Count ◽  
Interleukin 2 ◽  
Cd4 T Cell ◽  
T Cell Survival ◽  
Cd4 T Cell Count

Beta-2 Microglobulin and Soluble Interleukin-2 Receptor Serum Levels Correlates with Human Immunodeficiency Virus Associated Non-Hodgkins Lymphoma-Diffuse Large B-Cell Lymphoma (HIV-NHL-DLBCL).

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 4675-4675
Author(s):  
Eugene McPherson ◽  
J. Ng ◽  
E. Hazel ◽  
P. Tassy
Keyword(s):  
Viral Load ◽  
T Cell ◽  
Cell Count ◽  
Interleukin 2 ◽  
Serum Levels ◽  
Cd4 T Cell ◽  
Soluble Interleukin 2 Receptor ◽  
Beta 2 ◽  
Beta 2 Microglobulin ◽  
Cd4 T Cell Count

Abstract Beta-2-microglobulin (B2M) is a cell surface protein on many somatic cells including T and B lymphocytes and macrophages as a subunit of class I major histocompatibilty complex (MHC). Soluble interleukin-2 receptor (sIL-2R) is a T cell derived cytokine that induce proliferation of activated T cells, participates in differentiation of B cells and modulates macrophage function and phenotype. Both serum B2M and sIL-2R levels reflect immune-system activation and are elevated in patients with HIV-NHL-DLBCL. Combined detection of B2M and sIL-2R can be used to predict treatment response or failure in patients with aggressive HIV-NHL-DLBCL. When highly active antiretroviral therapy (HAART) chemotherapy is administered to refractoriness of elevated B2M and sIL-2R serum levels may be seen in HIV-NHL-DLBCL poor responders or failures. As sIL-2R levels decrease, B2M levels remain elevated in early stage HIV-NHL-DLBCL. Treatment of these patients with CHOP-rituximab and HAART both markers decrease. However, in late stage disease (stage III-IV, HIV-NHL-DLBCL based on DLBCL), B2M and sIL-2R remain significantly elevated and prognosis poor even after immune restoration of CD4+ T cell count and HIVRNA viral load approach normal. CASE: We present one of several cases - a 38 year old HIV positive male with DLBCL of his sinus turbinates, had turbinectomy surgery with sIL-2R level of 617 U/mL (5,460.226 pg/ml) postop which gradually increased to 27,673.95 pg/ml in less than six months. The B2M level while on HAART decreased from 18.8 mg/L to 4.4 mg/L. His LDH, CRP, and GGT levels were elevated but the CD4+ T cell count was 26% and his HIVRNA viral load became undetectable. After CHOP-rituximab therapy sIL-2R decreased to 10,806 pg/ml from 27,674 pg/ml but slowly rose to 39,975.25 pg/ml and B2M increased to 19 mg/L. The CD19+ B cell count was zero and a CD4/CD8 ratio improve to 0.546. CONCLUSION: B2M and sIL-2R serum level measurements provides data that when used together may offer a better management approach to these HIV-NHL-DLBCL patients. B2M and sIL-2R elevated refractory levels correlates with tumour burden and predicts poor prognosis in aggressive HIV-NHL-DLBCL.

The Effect of Antiretroviral Therapy on IL-6, IL-1β, TNF-α, IFN-γ Levels and their Relationship with HIV-RNA and CD4+ T Cells in HIV Patients

2020 ◽  
Vol 18 (5) ◽  
pp. 354-361
Author(s):  
Gülay Okay ◽  
Meliha Meric Koc ◽  
Eray Metin Guler ◽  
Ayşegül Yabaci ◽  
Abdürrahim Kocyigit ◽  
...  
Keyword(s):  
T Cell ◽  
Hiv Infection ◽  
Cell Count ◽  
Cd4 T Cell ◽  
Positive Correlation ◽  
Hiv Rna ◽  
Tnf Α ◽  
Cytokine Levels ◽  
Ifn Γ ◽  
Cd4 T Cell Count

Background: Serum cytokine levels over the course of HIV infection usually increase with immunosuppression and decrease after antiretroviral treatment (ART). Objectives: The aim of the study is to compare cytokine levels between HIV-infected patients (HIP) and controls and investigate the relationship between CD4+T cell count, HIV-RNA levels, and cytokine levels. Methods: The study subjects comprised ART-naive HIP (n=30) with no comorbidities and age-and sex-matched healthy controls. We measured levels of IL-6, IL-1β, TNF-α, and IFN-γ in serum samples of HIP at the beginning and at month 6 of ART and in controls. Results: The mean age of the study subjects was 38.7 ±10.3 years, with men making up 86.7% of the study subjects (n=26). IL-6, IL-1β, and TNF-α levels were significantly higher in both ART-naive (p<0.001, p=0.002, p=0.001) and ART-experienced HIP (p<0.001) than controls. The IFN-γ level was lower in both ART-naive and ART-experienced HIP compared to controls (p=0.082 and p=0.002). There was a positive correlation between the CD4+T cell count and serum concentration of IFN- γ(r=0.320, p<0.05). While the serum IFN-γ concentration showed a negative correlation with the HIVRNA level(r=-0.412, p<0.001), the serum IL-1β, IL-6, and TNF-α concentrations showed a positive correlation with the HIV-RNA level (r=0.349, p<0.001; r:0.54, p<0.001; r:0.438, p<0.00). Conclusions: Although serum concentrations of IL-6, IL-1β and TNF-α showed a significant decrease after ART, they were still significantly higher than the controls. IFN-γ responded differently to ART compared to the other cytokines, indicating that it may play a distinct and important role in the pathogenesis of HIV infection.

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