Biological thermometer based on the temperature sensitivity of magnetic nanoparticle paraSHIFT

2021 ◽  
Author(s):  
Silin Guo ◽  
WenTong Yi ◽  
Wenzhong Liu
Keyword(s):  
Magnetic Resonance ◽  
Chemical Shift ◽  
Magnetic Nanoparticle ◽  
Chemical Shifts ◽  
Peak Shift ◽  
Resonance Imaging ◽  
Temperature Dependent ◽  
Temperature Imaging ◽  
Measurement Temperature ◽  
Magnetic Resonance Imaging Mri

Abstract In the paper, the temperature dependence of magnetic nanoparticle (MNP) paramagnetic chemical shift (paraSHIFT) was studied by magnetic resonance (MR) spectroscopy. Based on it, iron oxide MNPs are considered as MR shifting probes for determining the temperature in liquids. With the increase in measurement temperature of the MNP reagent with MNPs, the decrease of MNP magnetization would make the peak of spectroscopy shift to the higher chemical shift area. The peak shift is related to the magnetic susceptibility of MNPs, which can be determined by MR frequency as a function of temperature and particle size. Experiments on temperature-dependent chemical shifts are performed for MNP samples with different core sizes and the estimated temperature accuracy can achieve 0.1K. Combined with the contrast effect of magnetic nanoparticles in magnetic resonance imaging (MRI) at 3 T, this technology can realize temperature imaging.

Could we assess the functional status, of hormone secreting, or non-secreting of the adrenal masses regarding their Magnetic Resonance Imaging (MRI) characteristics?

2021 ◽  
Vol 22 ◽  
Author(s):  
Gamze Akkus ◽  
Ferhat Piskin ◽  
Barış Karagun ◽  
Murat Sert ◽  
Mehtap Evran ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Chemical Shift ◽  
Functional Status ◽  
Signal Intensity ◽  
Adrenal Mass ◽  
Resonance Imaging ◽  
Intensity Index ◽  
Adrenal Masses ◽  
Magnetic Resonance Imaging Mri

Background: Diagnostic imaging techniques including magnetic resonance imaging (MRI) should also perform on all patients with incidentalomas. However, there is a limited study whether the quantitative measurements (signal intensity index, adrenal to spleen ratio) in MRI could predict the functional status of adrenal adenomas. Material-Method: Between 2015-2020; 404 patients (265 females, 139 males) with adrenal mass who were referred to the university hospital for further investigation were included. After detailed diagnostic hormonal evaluation, all patients underwent MRI 1.5 T device (Signa, GE Medical Systems; Milwaukee, USA). The signal intensities of the adrenal lesions on T2W images were qualitatively evaluated and noted as homogenous or heterogeneous in comparison with the liver signal intensity (SI). A chemical-shift SI index and chemical shift adrenal-to-spleen SI ratio were also calculated. Results: While 331(81.9%) of the patients had nonfunctional adrenal mass, the rest of them (n=73, 18.1%) were patients with functional (autonomous cortisol secretion-ACS, cushing syndrome-CS, pheochromocytoma, primary hyperaldosteronism-PA) adrenal masses. In phase vs phase values of patients with NFAI, Pheo(n=17), ACS (n=30), CS (n=11), and PA (n=15) were 474.04±126.7 vs 226.6±132.4, 495.3±182.8 vs 282.17±189.1, 445.2±134.8 vs 203.3±76.2, 506.8±126.5 vs 212.2±73.6 and 496.2±147.5 vs 246.6±102.1, respectively. Mean signal intensity index (SII) and adrenal to spleen ratio (ASR) of all groups (NFAI, Pheo, ACS, CS, PA) were 52.0±24.8 and 0.51, 44.9±22.5 and 0.55, 49.5±24.5 and 0.53, 56.2±16.4 and 0.43, 47.6±25.1 and 0.54, respectively. Based the current accepted measurements in the case of ASR and SII, all lesions were similar and shown as fat rich adenomas (p*= 0.552, p** = 0.45). Conclusion: The quantitative assessment (SII, ASR) of intracellular lipids in an incidentally discovered adrenal tumour could only help distinguish adrenal masses in case of adenomas or non-adenomas As initial diagnostic evaluation, clinical and laboratory assessment ,to distinguish hormone secretion, should be taken in all patients with adrenal incidentalomas.

scholarly journals Noninvasive Localization of Petroleum-derived Spray Oil in Plants with Chemical Shift Selective Magnetic Resonance Imaging

HortScience ◽  
2005 ◽  
Vol 40 (3) ◽  
pp. 720-725 ◽  
Author(s):  
B.L. Tan ◽  
N. Reddy ◽  
V. Sarafis ◽  
G.A.C. Beattie ◽  
R. Spooner-Hart
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Chemical Shift ◽  
Mineral Oil ◽  
Resonance Imaging ◽  
Outer Cortex ◽  
Peak Resolution ◽  
Oil Deposits ◽  
Magnetic Resonance Imaging Mri

Nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging (MRI) were used to detect petroleum-derived spray oils (PDSOs) in citrus seedlings and trees. The NMR spectrum of the phantom containing 10% (v/v) of a nC24 agricultural mineral oil (AMO) showed the resonance of the water protons at δ ≈ 5 ppm, while the resonance of the oil protons at δ = 1.3 to 1.7 ppm. The peak resolution and the chemical shift difference of more than 3.3 ppm between water and oil protons effectively differentiated water and the oil. Chemical shift selective imaging (CSSI) was performed to localize the AMO within the stems of Citrus trifoliata L. seedlings after the application of a 4% (v/v) spray. The chemical shift selective images of the oil were acquired by excitation at δ = 1.5 ppm by averaging over 400 transients in each phase-encoding step. Oil was mainly detected in the outer cortex of stems within 10 d of spray application; some oil was also observed in the inner vascular bundle and pith of the stems at this point. CSSI was also applied to investigate the persistence of oil deposits in sprayed mature Washington navel orange (Citrus ×aurantium L.) trees in an orchard. The trees were treated with either fourteen 0.25%, fourteen 0.5%, four 1.75%, or single 7% sprays of a nC23 horticultural mineral oil (HMO) 12 to 16 months before examination of plant tissues by CSSI, and were still showing symptoms of chronic phytotoxicity largely manifested as reduced yield. The oil deposits were detected in stems of sprayed flushes and unsprayed flushes produced 4 to 5 months after the last spray was applied, suggesting a potential movement of the oil via phloem and a correlation of the persistence of oil deposit in plants and the phytotoxicity. The results demonstrate that MRI is an effective method to probe the uptake and localization of PDSOs and other xenobiotics in vivo in plants noninvasively and nondestructively.

scholarly journals A Thymic Hyperplasia Case without Suppressing on Chemical Shift Magnetic Resonance Imaging

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Tuan Phung ◽  
Thach Nguyen ◽  
Dung Tran ◽  
Nga Phan ◽  
Hung Nguyen
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Chemical Shift ◽  
Thoracoscopic Surgery ◽  
Tumor Resection ◽  
Lymphoid Hyperplasia ◽  
Resonance Imaging ◽  
Chemical Shift Mri ◽  
Magnetic Resonance Imaging Mri ◽  
One Year

A 22-year-old woman with myasthenia gravis (MG) presented with ptosis and mild muscle weakness symptoms for one year. Computed tomography (CT) presented a diffuse bilobulate enlargement gland with a high density of soft tissue. Magnetic resonance imaging (MRI) showed the gland with no suppression on the opposed-phase chemical shift. After the thymic tumor diagnosis, she underwent thoracoscopic surgery for tumor resection. The postoperative histopathological finding was thymic lymphoid hyperplasia. This case suggests chemical shift MRI is not enough in distinguishing, and supplementary examination is essential to avoid unnecessary thymic biopsy and surgery.

scholarly journals Visualizing Electromagnetic Vacuum by MRI

2016 ◽  
Author(s):  
Chandrika S. Chandrashekar ◽  
Annadanesh Shellikeri ◽  
S. Chandrashekar ◽  
Erika A. Taylor ◽  
Deanne M. Taylor
Keyword(s):  
Magnetic Resonance ◽  
Chemical Shifts ◽  
Metal Strip ◽  
Surface Chemical ◽  
Resonance Imaging ◽  
Bulk Metal ◽  
Magnetic Resonance Imaging Mri ◽  
Further Development ◽  
Metal Block ◽  
Orthogonal Pairs

Based upon Maxwell's equations, it has long been established that oscillating electromagnetic (EM) fields incident upon a metal surface decay exponentially inside the conductor, leading to a virtual EM vacuum at sufficient depths. Magnetic resonance imaging (MRI) utilizes radiofrequency (r.f.) EM fields to produce images. Here we present the first visualization of an EM vacuum inside a bulk metal strip by MRI, amongst several novel findings. We uncover unexpected MRI intensity patterns arising from two orthogonal pairs of faces of a metal strip, and derive formulae for their intensity ratios. Further, we furnish chemical shift imaging (CSI) results that discriminate different faces (surfaces) of a metal block according to their distinct nuclear magnetic resonance (NMR) chemical shifts, which holds much promise for monitoring surface chemical reactions noninvasively. Bulk metals are ubiquitous, and MRI is a premier noninvasive diagnostic tool. Combining the two, the emerging field of bulk metal MRI can be expected to grow in importance. The fundamental nature of results presented here can impact and spur further development of bulk metal MRI and CSI across many fields.

scholarly journals Visualizing Electromagnetic Vacuum by MRI

2016 ◽  
Author(s):  
Chandrika S. Chandrashekar ◽  
Annadanesh Shellikeri ◽  
S. Chandrashekar ◽  
Erika A. Taylor ◽  
Deanne M. Taylor
Keyword(s):  
Magnetic Resonance ◽  
Chemical Shifts ◽  
Metal Strip ◽  
Surface Chemical ◽  
Resonance Imaging ◽  
Bulk Metal ◽  
Intensity Ratios ◽  
Magnetic Resonance Imaging Mri ◽  
Metal Block ◽  
Orthogonal Pairs

Based upon Maxwell's equations, it has long been established that oscillating electromagnetic (EM) fields incident upon a metal surface decay exponentially inside the conductor, leading to a virtual EM vacuum at sufficient depths. Magnetic resonance imaging (MRI) utilizes radiofrequency (r.f.) EM fields to produce images. Here we present the first visualization of a virtual EM vacuum inside a bulk metal strip by MRI, amongst several novel findings.We uncover unexpected MRI intensity patterns arising from two orthogonal pairs of faces of a metal strip, and derive formulae for their intensity ratios, revealing differing effective elemental volumes (voxels) underneath these faces.Further, we furnish chemical shift imaging (CSI) results that discriminate different faces (surfaces) of a metal block according to their distinct nuclear magnetic resonance (NMR) chemical shifts, which holds much promise for monitoring surface chemical reactions noninvasively.Bulk metals are ubiquitous, and MRI is a premier noninvasive diagnostic tool. Combining the two, the emerging field of bulk metal MRI can be expected to grow in importance. The fundamental nature of results presented here may impact bulk metal MRI and CSI across many fields.

Recent Advances in Magnetic Nanoparticle-based Molecular Probes for Hepatocellular Carcinoma Diagnosis and Therapy

2018 ◽  
Vol 24 (21) ◽  
pp. 2432-2437 ◽  
Author(s):  
Qi Zhang ◽  
Sudan Wang ◽  
Ruirui Qiao ◽  
Michael R. Whittaker ◽  
John F. Quinn ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Hepatocellular Carcinoma ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Magnetic Nanoparticle ◽  
Molecular Probes ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Mri ◽  
Screening And Diagnosis

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, leading to the second most likely cause of cancer-related deaths. Medical imaging is crucial in clinic for HCC screening and diagnosis. Due to the relatively high special resolution and excellent sensitivity, magnetic resonance imaging (MRI) by using magnetic nanoparticle-based contrast agents has been used so far in HCC imaging and staging, demonstrating great potential and promising in vivo applications. This review focuses on the use of different magnetic nanoparticles for construction of HCC nanoprobes for MR imaging and theranostic purpose.

scholarly journals Visualizing Electromagnetic Vacuum by MRI

2016 ◽  
Author(s):  
Chandrika S. Chandrashekar ◽  
Annadanesh Shellikeri ◽  
S. Chandrashekar ◽  
Erika A. Taylor ◽  
Deanne M. Taylor
Keyword(s):  
Magnetic Resonance ◽  
Chemical Shifts ◽  
Metal Strip ◽  
Surface Chemical ◽  
Resonance Imaging ◽  
Bulk Metal ◽  
Intensity Ratios ◽  
Magnetic Resonance Imaging Mri ◽  
Metal Block ◽  
Orthogonal Pairs

Based upon Maxwell's equations, it has long been established that oscillating electromagnetic (EM) fields incident upon a metal surface decay exponentially inside the conductor, leading to a virtual EM vacuum at sufficient depths. Magnetic resonance imaging (MRI) utilizes radiofrequency (r.f.) EM fields to produce images. Here we present the first visualization of a virtual EM vacuum inside a bulk metal strip by MRI, amongst several novel findings.We uncover unexpected MRI intensity patterns arising from two orthogonal pairs of faces of a metal strip, and derive formulae for their intensity ratios, revealing differing effective elemental volumes (voxels) underneath these faces.Further, we furnish chemical shift imaging (CSI) results that discriminate different faces (surfaces) of a metal block according to their distinct nuclear magnetic resonance (NMR) chemical shifts, which holds much promise for monitoring surface chemical reactions noninvasively.Bulk metals are ubiquitous, and MRI is a premier noninvasive diagnostic tool. Combining the two, the emerging field of bulk metal MRI can be expected to grow in importance. The fundamental nature of results presented here may impact bulk metal MRI and CSI across many fields.

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