scholarly journals Anti-inflammatory effect of ethyl acetate fraction of galing plant extract (Cayratia trifolia) on male wistar rats induced by carrageenan

2019 ◽  
Vol 1146 ◽  
pp. 012021 ◽  
Author(s):  
D Santoso ◽  
I K Sudiana ◽  
A S Rahayu ◽  
M Yunus
Keyword(s):  
Ethyl Acetate ◽  
Plant Extract ◽  
Wistar Rats ◽  
Ethyl Acetate Fraction ◽  
Cayratia Trifolia ◽  
Male Wistar Rats ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals ANTIOBESITY OF FRACTIONS WATER EXTRACT OF TAMARIND (TAMARINDUS INDICA L.) IN MALE WISTAR RATS INDUCED HIGH CARBOHYDRATE DIET

2018 ◽  
Vol 11 (13) ◽  
pp. 200
Author(s):  
Nurul Hidayah ◽  
Ketut Adnyana I ◽  
Ketut Adnyana I ◽  
Neng Fisheri ◽  
Neng Fisheri ◽  
...  
Keyword(s):  
Body Weight ◽  
Ethyl Acetate ◽  
Wistar Rats ◽  
Water Extract ◽  
Ethyl Acetate Fraction ◽  
High Carbohydrate Diet ◽  
Carbohydrate Diet ◽  
High Carbohydrate ◽  
Male Wistar Rats ◽  
Weight Decrease

Objective: The prevalence of obesity increases each year globally. Multifactorial etiology of obesity requires therapy management including changing of diet and medicines. Some of obesity drugs have shown ineffectiveness and safety. The previous study showed that water extract of tamarind could reduce body weight (bw). This study aimed to test the activity fraction of water extract tamarind as antiobesity using high carbohydrate diet.Method: The preventive research of antiobesity had done by given water fraction and ethyl acetate fraction of water extract tamarind following with induced high carbohydrate diet during 6th weeks in male Wistar rats. The parameters had observed including consumption of food, body weight, weight of feces, volume of urine, total cholesterols, triglycerides, blood glucose, index of organs, and accumulation of body fat.Result: The ethyl acetate fraction at doses 4.5 mg/kg bw has shown significantly effect to decrease of total cholesterols level and decrease of triglycerides level at weeks 6 (p<0.05). All the tests of fraction have shown activity inhibition of increased body weight, decrease of appetite, total cholesterols, triglycerides, and blood glucose. Meanwhile, mechanism action of antiobesity as increase defecation, urination, and decrease index of organs and accumulation of body fat have not shown by all these test fractions.Conclusion: The ethyl acetate fraction at doses of 4.5 mg/kg bw can inhibit raising of body weight, decrease of total cholesterols, and triglycerides level greater than the other test groups, where increasing of these levels of blood biochemistry was closely related to the pathology of obesity.

scholarly journals DIURETIC ACTIVITY OF MATOA LEAVES EXTRACTS (Pometiapinnata) AND ITS INFLUENCE ON POTASSIUM AND SODIUM LEVELS

2017 ◽  
Vol 10 (14) ◽  
pp. 31
Author(s):  
Ika Purwidyaningrum ◽  
Elin Yulinah Sukandar ◽  
Irda Fidrianny
Keyword(s):  
Ethyl Acetate ◽  
Wistar Rats ◽  
Urine Volume ◽  
Ethyl Acetate Fraction ◽  
Control Group ◽  
Diuretic Activity ◽  
Observation Study ◽  
Aqueous Fraction ◽  
Male Wistar Rats ◽  
Sodium And Potassium

Objective: The purpose of this study was to determine diuretic activity of matoa leaves (Pometiapinnata) extracts and fraction and its influence on potassium and sodium levels.Methods: Matoa leaves were extracted by reflux method followed by evaporation using rotary evaporator. The subjects were male Wistar rats that were divided into 11 group furosemide (3.6 mg/kg bw), control group CMC 0.5%, matoa leaves extracts with doses of 50 mg/kg bw, 100 mg/kg bw, 150 mg/kg bw, matoa leaves aqueous fraction with dose of 10.94 mg/kg bw, 21.88 mg/kg bw, 32.82 mg/kg bw, matoa leaves ethyl acetate fraction with dose of 4.35 mg/kg bw, 8.71 mg/kg bw, 13.06 mg/kg bw. Rats were placed in metabolic cagesduring observation study. Urine volume was measured for 5 to 24 hours. Potassium and sodium levels in urine were determined by using Atomic Absorption Spectrophotometry.Results: The effective dose of matoa leaves extract and fractions for diuretic activity was matoaleaves ethyl acetate fraction 8.71 mg/kg bw which could increase the excretion of sodium and potassium in the urine of the male Wistar rats.Conclusion:Matoa leaves extract and fractions could increase the excretion of sodium and potassium in the urine of the male Wistar rats.  

scholarly journals Defatted Hydroethanolic Extract of Ammodaucus leucotrichus Cosson and Durieu Seeds: Antidiabetic and Anti-Inflammatory Activities

2020 ◽  
Vol 10 (24) ◽  
pp. 9147
Author(s):  
Imane Es-Safi ◽  
Hamza Mechchate ◽  
Amal Amaghnouje ◽  
Anna Calarco ◽  
Smahane Boukhira ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Fasting Blood Glucose ◽  
Diabetic Mice ◽  
North African ◽  
Glucose Levels ◽  
The North ◽  
Blood Glucose Levels ◽  
Anti Inflammatory ◽  
Hydroethanolic Extract ◽  
Inflammatory Effect

The seeds of Ammodaucus leucotrichus Cosson and Durieu have been used in the North African Sahara as a traditional medicine to treat diabetes. The present study investigates the antidiabetic, antihyperglycemic, and anti-inflammatory properties of the defatted hydroethanolic extract of Ammodaucus leucotrichus (DHEAM). The antidiabetic and the antihyperglycemic studies were assessed on alloxan-induced diabetic with orally administered doses of DHEAM (100 and 200 mg/kg). At the same time, its anti-inflammatory propriety was evaluated by measuring edema development in the Wistar rats paw induced with carrageenan. Treatment of diabetic mice with DHEAM for four weeks managed their high fasting blood glucose levels, improved their overall health, and also revealed an excellent antihyperglycemic activity. Following the anti-inflammatory results, DHEAM exhibited a perfect activity. HPLC results revealed the presence of seven molecules (chlorogenic acid, 3-p-coumaroylquinic acid, gallic acid, ferulic acid, myricetin, quercetin, luteolin). This work indicates that the DHEAM has an important antidiabetic, antihyperglycemic, and anti-inflammatory effect that can be well established as a phytomedicine to treat diabetes.

41. Anti-Inflammatory Effect of Honey Bee Venom on Wistar Rats Induced Poly Cystic Ovarian Syndrome by Estradiol Valerate

Toxicon ◽  
2012 ◽  
Vol 60 (2) ◽  
pp. 115-116
Author(s):  
Mohammad Nabiuni ◽  
Kazem Parivar ◽  
Bahman Zeynali ◽  
Azar Sheikholeslami ◽  
Latifeh Karimzadeh
Keyword(s):  
Honey Bee ◽  
Wistar Rats ◽  
Bee Venom ◽  
Estradiol Valerate ◽  
Anti Inflammatory ◽  
Ovarian Syndrome ◽  
Inflammatory Effect

Effect of Chayote (Sechium Edule Jacq. Swartz) Extract on Level of Interleukin-8 in Wistar Rats with Aspirin-Induced Gastritis

2020 ◽  
Author(s):  
Hendrika Andriana Silitonga ◽  
◽  
Gontar Alamsyah Siregar ◽  
Rosita Juwita Sembiring ◽  
Marline Nainggolan ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Wistar Rats ◽  
Ethanol Extract ◽  
Ethyl Acetate Fraction ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Interleukin 8 ◽  
Control Group ◽  
Sechium Edule

ABSTRACT Background: Recent studies showed that Interleukin-8 (IL-8), activated cytokine immune response which plays an important role in the development of acute and chronic gastritis. Harmless anti-inflammatory therapeutic alternatives have been proposed, for example, the consumption of Sechium Edule Jacq. Swartz (chayote). Antioxidant (flavonoid) and cell regeneration (alkaloid) agents were found in chayote. This study aimed to determine the effect of chayote Sechium Edule Jacq. Swartz extracts on the level of IL-8 in Wistar rats with aspirin- induced gastritis. Subjects and Method: This was a randomized controlled trial (RCT) conducted at the laboratory of Mathematics and Natural Science, Universitas Sumatra Utara from January to February 2020. A total of 35 male Wistar rats was selected for this study and randomly allocated into 7 groups: (1) Negative control; (2) Positive control; (3) 100 mg/ kg BW chayote ethanol extract ; (4) 200 mg/kg BW chayote ethanol extract; (5) 100 mg/ kg BW chayote ethyl acetate fraction; (6) 200 mg/kg BW chayote ethyl acetate fraction; and (7) 20 mg omeprazole. The rats in positive control and treatment groups were induced with aspirin (200mg/ kg BW). The negative control group received no intervention. The dependent variable was level of IL-8 measured by ELISA. The independent variables were treatment status. The data were analyzed by One Way Anova and post hoc test. Results: The mean differences of IL-8 level were not statistically significant between study groups (p= 0.327). Mean of IL-8 level was higher in positive control group (Mean= 160.80; SD= 6.90) than in negative control group (Mean= 141.20; SD= 10.98). The lowest IL-8 level was in 100mg/ kg BW chayote ethanol extract group (Mean= 149.94; SD= 40.4), followed by 200mg/ kg BW (Mean= 152.4; SD= 30.73) and 100mg/ kg BW (Mean= 164.60; SD= 25.04) chayote ethyl acetate fraction groups, 20 mg omeprazole group (Mean= 170.60; SD= 21.58), and 200 mg/ kg BW chayote ethanol extract group (Mean= 176.80; SD= 10.98). Conclusion: The low dose (100mg/ kg BW) chayote ethanol extract has the most potential antiinflammation effect on in vitro gastritis with the lowest IL-8 level of all doses of chayote ethanol extract, chayote ethyl acetate fraction, and omeprazole. Keywords: antiinflammation, IL-8, chayote ethanol extract, ethyl acetate fraction, omeprazole, aspirin induced gastritis Correspondence: Hendrika Andriana Silitonga. Department of Histology, Faculty of Medicine, Universitas Methodist Indonesia. Email: [email protected]. Mobile: +6281361430688. DOI: https://doi.org/10.26911/the7thicph.05.35

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