scholarly journals Optimization Process In The Synthesis of Stannous Chloride (SnCl2) by Redox Method In The Context of Downstream Tin Derivative Product

2021 ◽  
Vol 1764 (1) ◽  
pp. 012034
Author(s):  
Nurul Wulandari ◽  
A S Wismogroho ◽  
W B Widayatno ◽  
M I Amal ◽  
D Y Kusuma
Keyword(s):  
Stannous Chloride ◽  
Optimization Process ◽  
Redox Method

A Facile One-Pot Synthesis of 3-Methylbenzisoxazoles via a Key Intermediate of ortho-Ethoxyvinyl Nitroaryls by Domino Rearrangement and Their Anti- Inflammatory Activity

2020 ◽  
Vol 16 (8) ◽  
pp. 1161-1165
Author(s):  
Bashetti Nagaraju ◽  
Jagarlapudi V. Shanmukhakumar ◽  
Nareshvarma Seelam ◽  
Tondepu Subbaiah ◽  
Bethanamudi Prasanna
Keyword(s):  
Stannous Chloride ◽  
Biologically Active ◽  
Inflammatory Activity ◽  
Albino Rats ◽  
One Pot ◽  
Simple Method ◽  
Standard Drug ◽  
Entire Study ◽  
One Pot Synthesis ◽  
Anti Inflammatory

Background: Recently, there has been a lot of scientific interest in exploring the syntheses of oxygen and nitrogen-containing heterocyclic compounds due to their pharmacological activities. In addition, benzisoxazoles play a very important role in organic synthesis as key intermediates. Objective: In this paper, we focused on developing a novel synthetic route for biologically active arylisoxazoles under normal conditions, and simplified it to get high purities and yields, and also reported their anti-inflammatory activities. Method: An efficient and simple method has been explored for the synthesis of novel 3-methyl arylisoxazoles from o-nitroaryl halides via o-ethoxyvinylnitroaryls, using dihydrated stannous chloride (SnCl2.2H2O) in MeOH / EtOAc (1:1) via Domino rearrangement in one pot synthesis. Result: We synthesized novel 3-methylarylisoxazoles from o-nitroarylhalides via o-ethoxyvinylnitroaryls, using dihydrated stannous chloride (SnCl2.2H2O) in MeOH / EtOAc (1:1) via domino rearrangement. In this reduction, nitro group and ethoxy vinyl group change to the functional acyl ketones, followed by hetero cyclization. Here, the reaction proceeds without the isolation of intermediates like 2-acylnitroarenes and 2- acylanilines. All the synthesized compounds were completely characterized by the NMR and mass spectra. The compounds were also explored for their anti-inflammatory activity by carrageenan-induced inflammation in the albino rats (150-200 g) of either sex used in this entire study with the use of Diclofenac sodium as the standard drug. The initial evaluations identified leading targets with good to moderate anti-inflammatory activity. Conclusion: A simple, one-pot and convenient method has been explored for the synthesis of novel 3- methylarylisoxazoles with high purity and reaction yields. All the compounds 3a, 3c, 3d, 3f, 3g and 3h exhibited 51-64% anti-inflammatory activities.

scholarly journals Wire Electrical Discharge Machining (WEDM) optimization process: A conceptual view

2020 ◽  
Vol 864 ◽  
pp. 012089
Author(s):  
Sharifah Zarith Rahmah Syed Ahmad ◽  
Azlan Mohd Zain ◽  
Yusliza Yusoff ◽  
Nurzal Effiyana Ghazali ◽  
Kai-Qing Zhou
Keyword(s):  
Electrical Discharge ◽  
Electrical Discharge Machining ◽  
Optimization Process ◽  
Wire Electrical Discharge Machining

scholarly journals The impact of end-userś participation (cancer patients) during the optimization process

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
S Houwaart
Keyword(s):  
End Users ◽  
Public Health Care ◽  
Optimization Process ◽  
Patient Organization ◽  
End User ◽  
The Public ◽  
Patient Organizations ◽  
Crucial Information ◽  
The Individual ◽  
The Impact

Abstract End-user (e.g. patients or the public) testing of information material is becoming more common in the German public health care system. However, including the end-user (in this case patients) in an optimisation process and thus enabling a close collaboration while developing PIMs is still rare. This is surprising, given the fact that patients provide the exact perspective one is trying to address. Within the isPO project, a patient organization is included as a legal project partner to act as the patient representative and provide the patient's perspective. As such, the patient organization was included in the PHR approach as part of the PIM-optimisation team. During the optimisation process, the patients gave practical insights into the procedures of diagnosing and treating different types of cancer as well as into the patient's changing priorities and challenges at different time points. This was crucial information for the envisioned application of the individual PIMs and their hierarchical overview. Moreover, the developed PIM-checklist enabled the patients to give detailed feedback to the PIMs. With their experience of being in the exact situation in which the PIMs will be applied, their recommendations, especially on the wording and layout of the materials, have been a valuable contribution to the PIM optimisation process. In this part of the seminar, we will take a closer look at the following skill building aspects: What is gained from including patients as end-users in the development and optimization of PIM?How can we reach patients to contribute to a PIM optimization process? Which requirements and prerequisites do patients have to provide to successfully work on an optimisation team?How to compromise and weigh opinions when different ideas occur? Altogether, this part will construct a structured path of productive patient involvement and help to overcome uncertainties regarding a collaboration with patient organizations.

Analysis and improvement of GSA’s optimization process

2021 ◽  
pp. 107367
Author(s):  
Su Fang ◽  
Duan Chengrui ◽  
Wang Ruopeng
Keyword(s):  
Optimization Process

scholarly journals Optimization and Characteristics Analysis of High Torque Density 12/8 Switched Reluctance Motor Using Metaheuristic Gray Wolf Optimization Algorithm

Energies ◽  
2021 ◽  
Vol 14 (7) ◽  
pp. 2013
Author(s):  
Md Sydur Rahman ◽  
Grace Firsta Lukman ◽  
Pham Trung Hieu ◽  
Kwang-II Jeong ◽  
Jin-Woo Ahn
Keyword(s):  
Switched Reluctance Motor ◽  
Optimization Process ◽  
Grey Wolf Optimizer ◽  
Gray Wolf ◽  
Switched Reluctance ◽  
Torque Density ◽  
Optimization Constraints ◽  
Reluctance Motor ◽  
Characteristics Analysis ◽  
And Performance

In this paper, the optimization and characteristics analysis of a three-phase 12/8 switched reluctance motor (SRM) based on a Grey Wolf Optimizer (GWO) for electric vehicles (EVs) application is presented. This research aims to enhance the output torque density of the proposed SRM. Finite element method (FEM) was used to analyze the characteristics and optimization process of the proposed motor. The proposed metaheuristic GWO combines numerous objective functions and design constraints with different weight factors. Maximum flux density, current density, and motor volume are selected as the optimization constraints, which play a significant role in the optimization process. GWO performs optimization for each iteration and sends it to FEM software to analyze the performance before starting another iteration until the optimized value is found. Simulations are employed to understand the characteristics of the proposed motor. Finally, the optimized prototype motor is manufactured and performance is verified by experiment. It is shown that the torque can be increased by 120% for the same outer volume, by using the proposed method.

scholarly journals Achieving selectivity in porphyrin bromination through a DoE-driven optimization under continuous flow conditions

2020 ◽  
Author(s):  
Paolo Zardi ◽  
Michele Maggini ◽  
Tommaso Carofiglio
Keyword(s):  
Reaction Time ◽  
Design Of Experiment ◽  
Continuous Flow ◽  
Optimization Process ◽  
Porphyrin Ring ◽  
Flow Conditions ◽  
Reaction Parameters ◽  
Synthetic Procedure ◽  
Relevant Factors ◽  
Post Functionalization

AbstractThe post-functionalization of porphyrins through the bromination in β position of the pyrrolic rings is a relevant transformation because the resulting bromoderivatives are useful synthons to covalently link a variety of chemical architectures to a porphyrin ring. However, single bromination of porphyrins is a challenging reaction for the abundancy of reactive β-pyrrolic positions in the aromatic macrocycle. We herein report a synthetic procedure for the efficient preparation of 2-bromo-5,10,15,20-tetraphenylporphyrin (1) under continuous flow conditions. The use of flow technology allows to reach an accurate control over critical reaction parameters such as temperature and reaction time. Furthermore, by performing the optimization process through a statistical DoE (Design of Experiment) approach, these parameters could be properly adjusted with a limited number of experiments. This process led us to a better understanding of the relevant factors that govern porphyrins monobromination and to obtain compound 1 with an unprecedent 80% yield.

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