scholarly journals Low Intensity Beam Extraction Mode on the Protom Synchrotron for Proton Radiography Implementation

2021 ◽  
Vol 2058 (1) ◽  
pp. 012041
Author(s):  
A A Pryanichnikov ◽  
P B Zhogolev ◽  
A E Shemyakov ◽  
M A Belikhin ◽  
A P Chernyaev ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Bragg Peak ◽  
Stopping Power ◽  
Experimental Measurements ◽  
Beam Extraction ◽  
Proton Radiography ◽  
Faraday Cup ◽  
Special Mode ◽  
Low Intensity ◽  
The Status

Abstract Proton radiography is one of the most important and actual areas of research that can significantly improve the quality and accuracy of proton therapy. Currently, the calculation of the proton range in patients receiving proton therapy is based on the conversion of Hounsfield CT units of the patient's tissues into the relative stopping power of protons. Proton radiography is able to reduce these uncertainties by directly measuring proton stopping power. The study demonstrates the possibility of Protom synchrotron-based proton therapy facilities to operate in a special mode which makes it possible to implement proton radiography. This work presents the status of the new low beam intensity extraction mode. The paper describes algorithms of low flux beam control, calibration procedures and experimental measurements. Measurements and calibration procedures were performed with certified Protom Faraday Cup, PTW Bragg Peak Chamber and specially designed experimental external.

scholarly journals Patient-specific stopping power calibration for proton therapy planning based on single-detector proton radiography

2015 ◽  
Vol 60 (5) ◽  
pp. 1901-1917 ◽  
Author(s):  
P J Doolan ◽  
M Testa ◽  
G Sharp ◽  
E H Bentefour ◽  
G Royle ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Stopping Power ◽  
Patient Specific ◽  
Therapy Planning ◽  
Proton Radiography ◽  
Single Detector

scholarly journals Role of GNPS on the Enhancement of Proton Therapy of Breast Tumor Using MCNPX Simulation

2021 ◽  
Author(s):  
seyede nasrin hosseinimotlagh ◽  
nasrin niknam ◽  
zohreh parang
Keyword(s):  
Proton Therapy ◽  
Breast Tumor ◽  
Bragg Peak ◽  
Absorbed Dose ◽  
Breast Tumors ◽  
Stopping Power ◽  
Optimal Range ◽  
Promising Strategy ◽  
Breast Phantom

Abstract Background: The beam therapy plays an important role in the treatment of cancer, which is the most common and successful form of treatment used after surgery. In proton therapy, proton beam (PB) particles irradiate the tumor. To enhance the treatment of breast tumor it is possible to inject gold nanoparticles (GNPS) into the tumor at the same time as irradiating the PB. The aim of this paper is the simulation of the treatment of breast tumors by using PBs and injecting GNPS with different concentrations, simultaneously. Therefore, we introduce the breast phantom (BP), then we irradiate it with a proton pencil beam, which is also injected with GNPS at the same time. In order to show the enhancement of the absorbed dose in the tumor, we use MCNPX.2.6 code. Results: The findings of our simulations show that the location of the Bragg's peak within the tumor shifts to higher depths with increasing energy. Also, by injecting GNPS in different amounts of 10, 25, 50 and 75 mg / ml with simultaneously irradiation of the PB, the rate of absorbed dose increases up to 1.75% compared to the non-injected state. Our results also show that the optimal range of proton energy that creates Bragg peaks within the tumor is between 52 to 65 MeV, which causes the creation of spread out of Bragg peak. It should be noted that the amount of absorbed dose is affected by quantities such as total stopping power, average Coulomb scattering angle, CSDA range and straggling range. Conclusion: This work offers new insights based on the use of GNPS in the treatment of breast cancer through proton therapy and indicates that the addition of GNPS is a promising strategy to increase the killing of cancer cells while irradiating fast PBs. In fact, the results of this study confirm the ability of GNPS to enhance treatment by increasing the absorbed dose in breast tumors using proton therapy.

Full treatment of the proton radiography technique for laser-driven capacitor-coil targets

2021 ◽  
Author(s):  
Xiaoxia Yuan ◽  
Cangtao Zhou ◽  
Hua Zhang ◽  
Jiayong Zhong ◽  
Bo Han ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Electromagnetic Fields ◽  
Small Angle ◽  
Primary Source ◽  
Numerical Calculations ◽  
Stopping Power ◽  
Magnetic Field Generation ◽  
Proton Radiography ◽  
Field Source ◽  
Comprehensive Study

Abstract Ultrafast proton radiography has been frequently used for direct measurement of the electromagnetic fields around laser-driven capacitor-coil targets. The goal is to accurately infer the coil currents and their magnetic field generation for a robust magnetic field source that can lead to many applications. The technique often involves numerical calculations for synthetic proton images to reproduce experimental measurements. While electromagnetic fields are the primary source for proton deflections around the capacitor coils, stopping power and small angle deflection can also contribute to the observed experimental features. Here we present a comprehensive study of the proton radiography technique including all sources of proton deflections as a function of coil shapes, current magnitudes, and proton energies. Good agreements were achieved between experimental data and numerical calculations that include both the stopping power and small angle deflections, particularly when the induced coil currents were small.

scholarly journals Evaluation of the effect of soft tissue composition on the characteristics of spread-out Bragg peak in proton therapy

2016 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
SayyedBijan Jia ◽  
Mahdi Ghorbani ◽  
Mohsen Khosroabadi ◽  
HamidReza Sadoughi ◽  
Courtney Knaup
Keyword(s):  
Soft Tissue ◽  
Proton Therapy ◽  
Bragg Peak ◽  
Tissue Composition ◽  
Soft Tissue Composition ◽  
Spread Out Bragg Peak

scholarly journals Measurement of the Beam Energy Distribution of a Medical Cyclotron with a Multi-Leaf Faraday Cup

Instruments ◽  
2019 ◽  
Vol 3 (1) ◽  
pp. 4 ◽  
Author(s):  
Konrad P. Nesteruk ◽  
Luca Ramseyer ◽  
Tommaso S. Carzaniga ◽  
Saverio Braccini
Keyword(s):  
Energy Distribution ◽  
Beam Energy ◽  
University Hospital ◽  
Stopping Power ◽  
Particle Accelerators ◽  
Faraday Cup ◽  
Range Distribution ◽  
Accurate Knowledge ◽  
Thin Aluminum ◽  
Design Construction

Accurate knowledge of the beam energy distribution is crucial for particle accelerators, compact medical cyclotrons for the production of radioisotopes in particular. For this purpose, a compact instrument was developed, based on a multi-leaf Faraday cup made of thin aluminum foils interleaved with plastic absorbers. The protons stopping in the aluminum foils produce a measurable current that is used to determine the range distribution of the proton beam. On the basis of the proton range distribution, the beam energy distribution is assessed by means of stopping-power Monte Carlo simulations. In this paper, we report on the design, construction, and testing of this apparatus, as well as on the first measurements performed with the IBA Cyclone 18-MeV medical cyclotron in operation at the Bern University Hospital.

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