scholarly journals Using the automated Verasonics system for physical modeling of skeletal muscle biomechanics

2021 ◽  
Vol 2134 (1) ◽  
pp. 012006
Author(s):  
P M Sinitsyn ◽  
I Yu Demin ◽  
A A Lisin ◽  
A E Spivak ◽  
Yu V Sinitsyna
Keyword(s):  
Mathematical Model ◽  
Skeletal Muscle ◽  
Connective Tissue ◽  
Physical Modeling ◽  
Layered Medium ◽  
Research System ◽  
Acoustic System ◽  
Software Algorithms ◽  
Ultrasound Diagnostics ◽  
Muscle Biomechanics

Abstract The paper describes the use of the Verasonics research system for physical modeling of skeletal muscle biomechanics. The scheme of the acoustic system is described. The path of receiving and processing the signal is presented. A brief overview of the operation of software algorithms for the implementation of methods of ultrasound diagnostics is made. A mathematical model of skeletal muscle as a flat-layered medium is considered. The implementation of this model in the form of a fibers agar phantom is proposed. Using the Verasonics acoustic system shear velocities of physical fibers agar phantom were measured. Shear modules for agar and fibers were calculated. The obtained values are consistent with similar characteristics of native muscles and connective tissue fibers.

scholarly journals A mathematical model of healthy and dystrophic skeletal muscle biomechanics

2020 ◽  
Vol 134 ◽  
pp. 103747
Author(s):  
Marco Stefanati ◽  
Chiara Villa ◽  
Yvan Torrente ◽  
José Félix Rodriguez Matas
Keyword(s):  
Mathematical Model ◽  
Skeletal Muscle ◽  
Muscle Biomechanics

Theoretical studies on capillary microviscometry of skeletal muscle actin

1983 ◽  
Vol 3 (2) ◽  
pp. 195-206
Author(s):  
Mitsuhiko Masuhara ◽  
Hiroyuki Yokoyama ◽  
Noriyuki Tatsumi
Keyword(s):  
Mathematical Model ◽  
Skeletal Muscle ◽  
Large Volume ◽  
Theoretical Studies ◽  
Muscle Actin

For improving Ostwald's viscometry, which is time-consuming and requires a relatively large volume of specimen to determine viscosity, we developed a capillary microviscometric method with an appropriate mathematical model, and have compared this method with Ostwald's method.

scholarly journals AUTORADIOGRAPHIC LOCALIZATION OF NEW RNA SYNTHESIS IN HYPERTROPHYING SKELETAL MUSCLE

1973 ◽  
Vol 57 (3) ◽  
pp. 743-759 ◽  
Author(s):  
Charles K. Jablecki ◽  
John E. Heuser ◽  
Seymour Kaufman
Keyword(s):  
Skeletal Muscle ◽  
Connective Tissue ◽  
Rna Synthesis ◽  
Proliferating Cells ◽  
Quantitative Studies ◽  
Physiological Adaptations ◽  
Rat Soleus Muscle ◽  
Tissue Cells ◽  
A Site ◽  
Silver Grains

Work-induced growth of rat soleus muscle is accompanied by an early increase in new RNA synthesis. To determine the cell type(s) responsible for the increased RNA synthesis, we compared light autoradiographs of control and hypertrophying muscles from rats injected with tritiated uridine 12, 24, and 48 h after inducing hypertrophy. There was an increased number of silver grains over autoradiographs of hypertrophied muscle. This increase occurred over connective tissue cells; there was no increase in the number of silver grains over the muscle fibers. Quantitative studies demonstrated that between 70 and 80% of the radioactivity in the muscle that survived fixation and washing was in RNA. Pretreatment of the animals with actinomycin D reduced in parallel both the radioactivity in RNA and the number of silver grains over autoradiographs. Proliferation of the connective tissue in hypertrophying muscle was evident in light micrographs, and electron micrographs identified the proliferating cells as enlarged fibroblasts and macrophages; the connective tissue cells remained after hypertrophy was completed. Thus, proliferating connective tissue cells are the major site of the increase in new RNA synthesis during acute work-induced growth of skeletal muscle. It is suggested that in the analysis of physiological adaptations of muscle, the connective tissue cells deserve consideration as a site of significant molecular activity.

scholarly journals A Histoarchitectural Approach to Skeletal Muscle Injury: Searching for a Common Nomenclature

2020 ◽  
Vol 8 (3) ◽  
pp. 232596712090909 ◽  
Author(s):  
◽  
Ramon Balius ◽  
Marc Blasi ◽  
Carles Pedret ◽  
Xavier Alomar ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Connective Tissue ◽  
Muscle Injury ◽  
Muscle Injuries ◽  
Macroscopic Anatomy ◽  
Skeletal Muscle Injury ◽  
Tissue Structures ◽  
Definition Of

In recent years, different classifications for muscle injuries have been proposed based on the topographic location of the injury within the bone-tendon-muscle chain. We hereby propose that in addition to the topographic classification of muscle injuries, a histoarchitectonic (description of the damage to connective tissue structures) definition of the injury be included within the nomenclature. Thus, the nomenclature should focus not only on the macroscopic anatomy but also on the histoarchitectonic features of the injury.

scholarly journals Improvement of Skeletal Muscle Regeneration by Platelet-Rich Plasma in Rats with Experimental Chronic Hyperglycemia

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Raed Rtail ◽  
Olena Maksymova ◽  
Viacheslav Illiashenko ◽  
Olena Gortynska ◽  
Oleksii Korenkov ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Connective Tissue ◽  
Muscle Regeneration ◽  
Platelet Rich Plasma ◽  
Triceps Surae ◽  
Skeletal Muscle Regeneration ◽  
Male Rats ◽  
Tissue Development ◽  
Muscle Recovery ◽  
Chronic Hyperglycemia

Herein, the structural effect of autologous platelet-rich plasma (PRP) on posttraumatic skeletal muscle regeneration in rats with chronic hyperglycemia (CH) was tested. 130 white laboratory male rats divided into four groups (I—control; II—rats with CH; III—rats with CH and PRP treatment; and IV—rats for CH confirmation) were used for the experiment. CH was simulated by streptozotocin and nicotinic acid administration. Triceps surae muscle injury was reproduced by transverse linear incision. Autologous PRP was used in order to correct the possible negative CH effect on skeletal muscle recovery. On the 28th day after the injury, the regenerating muscle fiber and blood vessel number in the CH+PRP group were higher than those in the CH rats. However, the connective tissue area in the CH group was larger than that in the CH+PRP animals. The amount of agranulocytes in the regenerating muscle of the CH rats was lower compared to that of the CH+PRP group. The histological analysis of skeletal muscle recovery in CH+PRP animals revealed more intensive neoangiogenesis compared to that in the CH group. Herewith, the massive connective tissue development and inflammation signs were observed within the skeletal muscle of CH rats. Obtained results suggest that streptozotocin-induced CH has a negative effect on posttraumatic skeletal muscle regeneration, contributing to massive connective tissue development. The autologous PRP injection promotes muscle recovery process in rats with CH, shifting it away from fibrosis toward the complete muscular organ repair.

Fluid exchange in skeletal muscle with viscoelastic blood vessels

1987 ◽  
Vol 253 (6) ◽  
pp. H1548-H1556
Author(s):  
J. Lee ◽  
E. P. Salathe ◽  
G. W. Schmid-Schonbein
Keyword(s):  
Experimental Data ◽  
Mathematical Model ◽  
Skeletal Muscle ◽  
Blood Cells ◽  
Constant Pressure ◽  
Tissue Fluid ◽  
Flow State ◽  
Governing Equations ◽  
Fluid Exchange ◽  
Better Than

A mathematical model of capillary-tissue fluid exchange in a viscoelastic blood vessel is presented, and the Landis occlusion experiment is simulated. The model assumes that the fluid exchange is governed by Starling's law and that the protein and red blood cells are conserved in the capillary. Before occlusion, in the steady flow state, the pressure in the capillary decreases from the arterial to venous end due to viscous dissipation. After occlusion a constant pressure is established along the capillary. We assume the capillary to be distensible with viscoelastic wall properties. Immediately following occlusion an instantaneous distension of the capillary occurs. The vessel continues to expand viscoelastically while fluid is filtered for a period of several minutes, until it reaches an equilibrium state. A full numerical solution of the governing equations has been obtained. We use this model to compute the distance variation between two labeled erythrocytes as obtained in the Landis occlusion experiment and compare the results with experimental data obtained recently for the spinotrapezius muscle in our laboratory. The new model can fit the experimental data better than previous models that neglect the distensibility of the capillaries.

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