Near-infrared emitting graphene quantum dots synthesized from reduced graphene oxide for in vitro/in vivo/ex vivo bioimaging applications

2D Materials ◽  
2021 ◽  
Vol 8 (3) ◽  
pp. 035013
Author(s):  
Md Tanvir Hasan ◽  
Bong Han Lee ◽  
Ching-Wei Lin ◽  
Ainsley McDonald-Boyer ◽  
Roberto Gonzalez-Rodriguez ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Near Infrared ◽  
Ex Vivo ◽  
Graphene Quantum Dots ◽  
Reduced Graphene

Lidocaine-loaded reduced graphene oxide hydrogel for prolongation of effects of local anesthesia: In vitro and in vivo analyses

2021 ◽  
Vol 35 (8) ◽  
pp. 1034-1042
Author(s):  
Weifan Li ◽  
Guangqi Zhang ◽  
Xiaoxia Wei
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Local Anesthesia ◽  
Ex Vivo ◽  
Tail Flick ◽  
Tail Flick Test ◽  
Duration Of Action ◽  
Reduced Graphene

Lidocaine is widely used as a local anesthetic for alleviation of post-operative pain and for management of acute and chronic painful conditions. Although several approaches are currently used to prolong the duration of action, an effective strategy to achieve neural blockage for several hours remains to be identified. In this study, a lidocaine-loaded Pluronic® F68-reduced graphene oxide hydrogel was developed to achieve sustained release of lidocaine. Fourier transform infrared spectroscopy, X-ray diffraction, and Raman spectroscopy confirmed the synthesis of Pluronic® F68-reduced graphene oxide. Transmission electron microscopy showed wrinkled, flat nanosheets with micelles attached. The developed hydrogel showed desirable pH, viscosity, adhesiveness, hardness, and cohesiveness for topical application. The ex vivo release study demonstrated the ability of the Pluronic® F68-reduced graphene oxide hydrogel to prolong release up to 10 h, owing to the strong π–π interactions between the graphene oxide and the lidocaine. In comparison with a commercial lidocaine ointment, the developed graphene oxide hydrogel showed sustained anesthetic effect in the radiant heat tail flick test and sciatic nerve block model. Thus, this study demonstrates the potential of using Pluronic® F68-reduced graphene oxide nanocarriers to realize prolonged effects of local anesthesia for effective pain management.

scholarly journals Biomimetic reduced graphene oxide coated collagen scaffold for in situ bone regeneration

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sajad Bahrami ◽  
Nafiseh Baheiraei ◽  
Mostafa Shahrezaee
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Cranial Bone ◽  
Drying Methods ◽  
Porous Scaffolds ◽  
Alizarin Red ◽  
Reduced Graphene ◽  
Coated Collagen

AbstractA variety of bone-related diseases and injures and limitations of traditional regeneration methods require new tissue substitutes. Tissue engineering and regeneration combined with nanomedicine can provide different natural or synthetic and combined scaffolds with bone mimicking properties for implantation in the injured area. In this study, we synthesized collagen (Col) and reduced graphene oxide coated collagen (Col-rGO) scaffolds, and we evaluated their in vitro and in vivo effects on bone tissue repair. Col and Col-rGO scaffolds were synthesized by chemical crosslinking and freeze-drying methods. The surface topography, and the mechanical and chemical properties of scaffolds were characterized, showing three-dimensional (3D) porous scaffolds and successful coating of rGO on Col. The rGO coating enhanced the mechanical strength of Col-rGO scaffolds to a greater extent than Col scaffolds by 2.8 times. Furthermore, Col-rGO scaffolds confirmed that graphene addition induced no cytotoxic effects and enhanced the viability and proliferation of human bone marrow-derived mesenchymal stem cells (hBMSCs) with 3D adherence and expansion. Finally, scaffold implantation into rabbit cranial bone defects for 12 weeks showed increased bone formation, confirmed by Hematoxylin–Eosin (H&E) and alizarin red staining. Overall, the study showed that rGO coating improves Col scaffold properties and could be a promising implant for bone injuries.

scholarly journals Composites of Graphene Quantum Dots and Reduced Graphene Oxide as Catalysts for Nitroarene Reduction

ACS Omega ◽  
2017 ◽  
Vol 2 (10) ◽  
pp. 7293-7298 ◽  
Author(s):  
Jiali Zhang ◽  
Fangwei Zhang ◽  
Yaoyao Yang ◽  
Shouwu Guo ◽  
Jingyan Zhang
Keyword(s):  
Quantum Dots ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Graphene Quantum Dots ◽  
Reduced Graphene ◽  
Nitroarene Reduction

Facile and simultaneous synthesis of graphene quantum dots and reduced graphene oxide for bio-imaging and supercapacitor applications

2016 ◽  
Vol 40 (11) ◽  
pp. 9111-9124 ◽  
Author(s):  
A. Muthurasu ◽  
P. Dhandapani ◽  
V. Ganesh
Keyword(s):  
Quantum Dots ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Graphene Quantum Dots ◽  
Reduced Graphene ◽  
Bio Imaging ◽  
Simultaneous Synthesis ◽  
Supercapacitor Applications

A simple and facile method for the simultaneous preparation of graphene quantum dots (GQDs) having different emission colours, viz., yellow, green and blue, and reduced graphene oxide (RGO) utilized respectively for bio-imaging and supercapacitor applications is demonstrated.

scholarly journals Enhancement of Molten Nitrate Thermal Properties by Reduced Graphene Oxide and Graphene Quantum Dots

ACS Omega ◽  
2020 ◽  
Vol 5 (34) ◽  
pp. 21345-21354
Author(s):  
Esraa Hamdy ◽  
Laila Saad ◽  
Fuad Abulfotuh ◽  
Moataz Soliman ◽  
Shaker Ebrahim
Keyword(s):  
Quantum Dots ◽  
Graphene Oxide ◽  
Thermal Properties ◽  
Reduced Graphene Oxide ◽  
Graphene Quantum Dots ◽  
Reduced Graphene

Alcohol dehydration performance of pervaporation composite membranes with reduced graphene oxide and graphene quantum dots homostructured filler

Carbon ◽  
2020 ◽  
Vol 162 ◽  
pp. 318-327 ◽  
Author(s):  
Rumwald Leo G. Lecaros ◽  
Ma. Elizabeth Bismonte ◽  
Bonifacio T. Doma ◽  
Wei-Song Hung ◽  
Chien-Chieh Hu ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Graphene Quantum Dots ◽  
Composite Membranes ◽  
Alcohol Dehydration ◽  
Reduced Graphene

The Role of Reduced Graphene Oxide Concentration as Ablated Material on Optical Properties of Graphene Quantum Dots

2019 ◽  
Vol 948 ◽  
pp. 267-273 ◽  
Author(s):  
Fiqhri Heda Murdaka ◽  
Ahmad Kusumaatmaja ◽  
Isnaeni ◽  
Iman Santoso
Keyword(s):  
Quantum Dots ◽  
Optical Properties ◽  
Graphene Oxide ◽  
Band Gap ◽  
Reduced Graphene Oxide ◽  
Optical Band Gap ◽  
Graphene Quantum Dots ◽  
Absorption Peak ◽  
Oxygen Defect ◽  
Reduced Graphene

We report the synthesize of Graphene Quantum Dots (GQDs) using ablation method with reduced Graphene Oxide (rGO) solution as a starting material. We have varied the concentration of rGO as following: 0.5, 2, 5 mg/ml and then have ablated them using 800 nm Ti-Sapphire femtosecond laser to obtain GQDs. From the UV-Vis data, we observed that the more concentration of rGO is being ablated, the more secondary absorption peak at 255.1 nm appeared. This secondary absorption peak is a characteristic of n-π* bonding due to the presence of oxygen defect which occurs as a result of the interaction between the laser and the water in rGO solution. We conclude that the population of oxigen defect in GQDs is increasing, following the increase of rGO concentration and could alter the optical properties of GQD. On the other hand, using Tauc’s plot, we confirm that the increase of rGO concentration as the ablated material does not alter GQDs optical band gap. However, it will slightly reduce both, direct and indirect Oxygen defect related optical band gap.

(Invited) In Vitro and In Vivo Near-Infrared Imaging with Biocompatible Bottom-up and Top-Down-Synthesized Graphene Quantum Dots

2020 ◽  
Vol MA2020-01 (6) ◽  
pp. 648-648
Author(s):  
Anton V Naumov ◽  
Md Tanvir Hasan ◽  
Elizabeth Campbell ◽  
Ching-Wei Lin ◽  
Angela M. Belcher
Keyword(s):  
Quantum Dots ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Graphene Quantum Dots ◽  
Top Down ◽  
Near Infrared Imaging ◽  
Bottom Up
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