One-pot synthesis of highly magnetic and stable citrate coated superparamagnetic iron oxide nanoparticles by modified coprecipitation method

2020 ◽  
Vol 2 (4) ◽  
pp. 045005
Author(s):  
Osama Abu Noqta ◽  
Bashiru Kayode Sodipo ◽  
Azlan Abdul Aziz
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Coprecipitation Method ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
One Pot ◽  
One Pot Synthesis

Synthesis of PVP Coated Superparamagnetic Iron Oxide Nanoparticles with a High Saturation Magnetization

2019 ◽  
Vol 290 ◽  
pp. 301-306
Author(s):  
Osama Abu Noqta ◽  
Azlan Abdul Aziz ◽  
Adamu Ibrahim Usman
Keyword(s):  
Iron Oxide ◽  
Saturation Magnetization ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
High Saturation Magnetization ◽  
One Pot ◽  
High Saturation ◽  
Size Of Particles

Superparamagnetic iron oxide nanoparticles (SPION) were synthesized by one pot coprecipitation method at room temperature in the presence of Polyvinylpyrrolidone (PVP). X-ray powder diffraction (XRD), transmission electron microscopy (TEM), and Vibrating Sample Magnetometer (VSM) were used to analysis the physicochemical properties of PVP-SPION. The XRD patterns confirmed that the structure of as-synthesized sample is magnetite with cubic structure system. In TEM results, the image of PVP-SPION displayed that the size of particles was 14.05 nm with narrower size distribution and also the PVP played important role to minimize the agglomeration of SPION. Finally, the high saturation magnetization value of PVP-SPION (53.0 emu/g) indicate the as-synthesized sample has a great potential as a contrast agent for MRI.

One-pot Electro-synthesis and Characterization of Chitosan Capped Superparamagnetic Iron Oxide Nanoparticles (SPIONs) from Ethanol Media

2017 ◽  
Vol 14 (1) ◽  
pp. 42-49 ◽  
Author(s):  
Mustafa Aghazadeh ◽  
Isa Karimzadeh
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Magnetic Particles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Sem Images ◽  
One Pot ◽  
Xrd Patterns

Background: Superparamagnetic iron oxide nanoparticles (SPIONs) are known for various biomedical applications like hyperthermia, magnetic resonance imaging and drug delivery. These magnetic particles should be capped with certain biocompatible agents. In this regard, it is a technological challenge to control size, shape, stability, and dispersibility of SPIONs in desired mediums. Methods: Cathodic electrosynthesis procedure was used for the preparation of naked SPIONs. Naked SPIONs were prepared by galvanostatic electrodeposition by applying the current density of 5 mA cm-2 for 30 min. For preparation of chitosan capped SPIONs, only the composition of deposition electrolyte was changed with the addition of 1 g L–1 chitosan. The prepared NPs were characterized through FE-SEM, TEM, XRD, DLS and VSM techniques. Results: The XRD patterns have the well-defined and relative broad diffraction peaks, which confirmed spinal magnetite structure for both naked CS capped SPIONs. FE-SEM images which clearly showed that both samples have a well-defined 10nm particles with no obvious aggregation. IR bands related to the chemical bonds of chitosan were observed, which proved a chitosan coating. The superparamagnetic nature of the prepared naked and CS-SPIONs were confirmed by VSM data. Conclusion: In summary, a facile electrochemical based platform was developed for the synthesis of chitosan capped superparamagnetic iron oxide nanoparticles from ethanol media. The observed weight loss (~16%) during the calcination of the CS- SPIONs, and also the presence of vibration bands related to the chitosan bands confirmed the chitosan layer on the SPIONs. Also, superparamagnetic nature of the CS capped SPIONs was confirmed by VSM data.

scholarly journals Synthesis and Characterization of Citrate-Stabilized Gold-Coated Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications

Molecules ◽  
2020 ◽  
Vol 25 (19) ◽  
pp. 4425
Author(s):  
René Stein ◽  
Bernhard Friedrich ◽  
Marina Mühlberger ◽  
Nadine Cebulla ◽  
Eveline Schreiber ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Biomedical Applications ◽  
Particle Surface ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Jurkat Cells ◽  
Major Influence ◽  
Oxide Nanoparticles ◽  
One Pot

Surface-functionalized gold-coated superparamagnetic iron oxide nanoparticles (Au-SPIONs) may be a useful tool in various biomedical applications. To obtain Au-SPIONs, gold salt was precipitated onto citrate-stabilized SPIONs (Cit-SPIONs) using a simple, aqueous one-pot technique inspired by the Turkevich method of gold nanoparticle synthesis. By the further stabilization of the Au-SPION surface with additional citrate (Cit-Au-SPIONs), controllable and reproducible Z-averages enhanced long-term dispersion stability and moderate dispersion pH values were achieved. The citrate concentration of the reaction solution and the gold/iron ratio was found to have a major influence on the particle characteristics. While the gold-coating reduced the saturation magnetization to 40.7% in comparison to pure Cit-SPIONs, the superparamagnetic behavior of Cit-Au-SPIONs was maintained. The formation of nanosized gold on the SPION surface was confirmed by X-ray diffraction measurements. Cit-Au-SPION concentrations of up to 100 µg Fe/mL for 48 h had no cytotoxic effect on Jurkat cells. At a particle concentration of 100 µg Fe/mL, Jurkat cells were found to take up Cit-Au-SPIONs after 24 h of incubation. A significantly higher attachment of thiol-containing L-cysteine to the particle surface was observed for Cit-Au-SPIONs (53%) in comparison to pure Cit-SPIONs (7%).

TARGETING CYCLIN B1 WITH ANTISENSE OLIGONUCLETOTIDES- COATED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES

2018 ◽  
Vol 6 (10) ◽  
Author(s):  
Hosam Zaghloul ◽  
Doaa A. Shahin ◽  
Ibrahim El- Dosoky ◽  
Mahmoud E. El-awady ◽  
Fardous F. El-Senduny ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cellular Uptake ◽  
Superparamagnetic Iron Oxide ◽  
Cyclin B1 ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Mcf7 Cells ◽  
M Phase ◽  
The Impact

Antisense oligonucleotides (ASO) represent an attractive trend as specific targeting molecules but sustain poor cellular uptake meanwhile superparamagnetic iron oxide nanoparticles (SPIONs) offer stability of ASO and improved cellular uptake. In the present work we aimed to functionalize SPIONs with ASO targeting the mRNA of Cyclin B1 which represents a potential cancer target and to explore its anticancer activity. For that purpose, four different SPIONs-ASO conjugates, S-M (1–4), were designated depending on the sequence of ASO and constructed by crosslinking carboxylated SPIONs to amino labeled ASO. The impact of S-M (1–4) on the level of Cyclin B1, cell cycle, ROS and viability of the cells were assessed by flowcytometry. The results showed that S-M3 and S-M4 reduced the level of Cyclin B1 by 35 and 36%, respectively. As a consequence to downregulation of Cyclin B1, MCF7 cells were shown to be arrested at G2/M phase (60.7%). S-M (1–4) led to the induction of ROS formation in comparison to the untreated control cells. Furthermore, S-M (1–4) resulted in an increase in dead cells compared to the untreated cells and SPIONs-treated cells. In conclusion, targeting Cyclin B1 with ASO-coated SPIONs may represent a specific biocompatible anticancer strategy.

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