Tissue Engineering for the Correction of Deficits in Body Structure and Function

2002 ◽  
Vol 3 (1) ◽  
pp. 1-6
Author(s):  
Anthony Atala
2019 ◽  
Vol 33 (2) ◽  
pp. 96-111 ◽  
Author(s):  
Katia Monte-Silva ◽  
Daniele Piscitelli ◽  
Nahid Norouzi-Gheidari ◽  
Marc Aureli Pique Batalla ◽  
Philippe Archambault ◽  
...  

Background. Clinical trials have demonstrated some benefits of electromyogram-triggered/controlled neuromuscular electrical stimulation (EMG-NMES) on motor recovery of upper limb (UL) function in patients with stroke. However, EMG-NMES use in clinical practice is limited due to a lack of evidence supporting its effectiveness. Objective. To perform a systematic review and meta-analysis to determine the effects of EMG-NMES on stroke UL recovery based on each of the International Classification of Functioning, Disability, and Health (ICF) domains. Methods. Database searches identified clinical trials comparing the effect of EMG-NMES versus no treatment or another treatment on stroke upper extremity motor recovery. A meta-analysis was done for outcomes at each ICF domain (Body Structure and Function, Activity and Participation) at posttest (short-term) and follow-up periods. Subgroup analyses were conducted based on stroke chronicity (acute/subacute, chronic phases). Sensitivity analysis was done by removing studies rated as poor or fair quality (PEDro score <6). Results. Twenty-six studies (782 patients) met the inclusion criteria. Fifty percent of them were considered to be of high quality. The meta-analysis showed that EMG-NMES has a robust short-term effect on improving UL motor impairment in the Body Structure and Function domain. No evidence was found in favor of EMG-NMES for the Activity and Participation domain. EMG-NMES had a stronger effect for each ICF domain in chronic (≥3 months) compared to acute/subacute phases. Conclusion. EMG-NMES is effective in the short term in improving UL impairment in individuals with chronic stroke.


F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 2158 ◽  
Author(s):  
Ivana Gadjanski

Articular cartilage (AC) is a seemingly simple tissue that has only one type of constituting cell and no blood vessels and nerves. In the early days of tissue engineering, cartilage appeared to be an easy and promising target for reconstruction and this was especially motivating because of widespread AC pathologies such as osteoarthritis and frequent sports-induced injuries. However, AC has proven to be anything but simple. Recreating the varying properties of its zonal structure is a challenge that has not yet been fully answered. This caused the shift in tissue engineering strategies toward bioinspired or biomimetic approaches that attempt to mimic and simulate as much as possible the structure and function of the native tissues. Hydrogels, particularly gradient hydrogels, have shown great potential as components of the biomimetic engineering of the cartilaginous tissue.


2020 ◽  
Vol 8 (5) ◽  
pp. 863-877 ◽  
Author(s):  
Adam D. Martin ◽  
Pall Thordarson

Self-assembling short peptides have widespread applications in energy materials, tissue engineering, sensing and drug delivery. In this review we discuss the effect of functional N-terminal capping groups on peptide structure and function.


2017 ◽  
Vol 53 (53) ◽  
pp. 7412-7415 ◽  
Author(s):  
Alec S. T. Smith ◽  
Hyok Yoo ◽  
Hyunjung Yi ◽  
Eun Hyun Ahn ◽  
Justin H. Lee ◽  
...  

Topographic and graphene-functionalized culture substrates were fabricated to regulate cardiac structure and function through manipulation of micro- and nano-scale mechanical and electroconductive cues.


2021 ◽  
Vol 5 (1) ◽  
pp. 22
Author(s):  
Miranie Safaringga ◽  
Uliy Iffah ◽  
Adinda Permata Sari

Children under five years of age when the increase in body structure and function becomes more complex and the ability to move fine, fine motion, language, and independence. The number of children under five who do not develop according to their age is triggered by parental care, where this care aims to meet the basic needs of toddlers so that they can grow and develop more optimally. The purpose of this study was to determine the relationship between parenting and the development of children aged 1-5 years in the working area of Puskesmas Rawang, Padang City. This research uses quantitative design with a cross section. This research was conducted in the working area of Puskesmas Rawang, Padang City. Data collection was carried out in March 2020. The sample of this study is mothers who have children aged 1-5 years who are in the working area of Puskesmas Rawang, Padang City, amounting to 79 people. The technique used in this study is proportional random sampling, for data collection using a questionnaire. The results of this study obtained 79 respondents consisting of mothers and toddlers with an average age of 12-24 months. Descriptively democratic parenting has a proportion of under five development in accordance with the highest value, namely 95.6% while authoritarian is 11.5%. Democratic parenting style affects the optimal development of toddlers.


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