Predictors of virological failure among people living with HIV switching from an effective first-line antiretroviral regimen.

2021 ◽  
Author(s):  
Laura Magnasco ◽  
Rachele Pincino ◽  
Giuseppe Pasculli ◽  
Yagai Bouba ◽  
Francesco Saladini ◽  
...  
Keyword(s):  
Virological Failure ◽  
People Living With Hiv ◽  
First Line ◽  
Living With Hiv

scholarly journals Predictors of virological failure among people living with HIV receiving first line antiretroviral treatment in Myanmar: retrospective cohort analysis

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Anita Mesic ◽  
Alexander Spina ◽  
Htay Thet Mar ◽  
Phone Thit ◽  
Tom Decroo ◽  
...  
Keyword(s):  
Viral Load ◽  
Virological Failure ◽  
Antiretroviral Treatment ◽  
People Living With Hiv ◽  
First Line ◽  
Hiv Viral Load ◽  
Loss To Follow Up ◽  
History Of ◽  
Living With Hiv

Abstract Background Progress toward the global target for 95% virological suppression among those on antiretroviral treatment (ART) is still suboptimal. We describe the viral load (VL) cascade, the incidence of virological failure and associated risk factors among people living with HIV receiving first-line ART in an HIV cohort in Myanmar treated by the Médecins Sans Frontières in collaboration with the Ministry of Health and Sports Myanmar. Methods We conducted a retrospective cohort study, including adult patients with at least one HIV viral load test result and having received of at least 6 months’ standard first-line ART. The incidence rate of virological failure (HIV viral load ≥ 1000 copies/mL) was calculated. Multivariable Cox’s regression was performed to identify risk factors for virological failure. Results We included 25,260 patients with a median age of 33.1 years (interquartile range, IQR 28.0–39.1) and a median observation time of 5.4 years (IQR 3.7–7.9). Virological failure was documented in 3,579 (14.2%) participants, resulting in an overall incidence rate for failure of 2.5 per 100 person-years of follow-up. Among those who had a follow-up viral load result, 1,258 (57.1%) had confirmed virological failure, of which 836 (66.5%) were switched to second-line treatment. An increased hazard for failure was associated with age ≤ 19 years (adjusted hazard ratio, aHR 1.51; 95% confidence intervals, CI 1.20–1.89; p < 0.001), baseline tuberculosis (aHR 1.39; 95% CI 1.14–1.49; p < 0.001), a history of low-level viremia (aHR 1.60; 95% CI 1.42–1.81; p < 0.001), or a history of loss-to-follow-up (aHR 1.24; 95% CI 1.41–1.52; p = 0.041) and being on the same regimen (aHR 1.37; 95% CI 1.07–1.76; p < 0.001). Cumulative appointment delay was not significantly associated with failure after controlling for covariates. Conclusions VL monitoring is an important tool to improve programme outcomes, however limited coverage of VL testing and acting on test results hampers its full potential. In our cohort children and adolescents, PLHIV with history of loss-to-follow-up or those with low-viremia are at the highest risk of virological failure and might require more frequent virological monitoring than is currently recommended.

Risk Factor Of Substitution ARV First Line People Living With HIV/AIDS In General Hospital Buleleng Bali

2020 ◽  
Vol 9 (1) ◽  
pp. 190-197
Author(s):  
Luh Putu Desy Puspaningrat ◽  
Gusti Putu Candra ◽  
Putu Dian Prima Kusuma Dewi ◽  
I Made Sundayana ◽  
Indrie Lutfiana
Keyword(s):  
Risk Factor ◽  
General Hospital ◽  
Medical Records ◽  
Secondary Data ◽  
District General Hospital ◽  
People Living With Hiv ◽  
First Line ◽  
The Past ◽  
Factor Substitution ◽  
Living With Hiv

Substitution is still a threat to the failure of ARV therapy so that no matter how small it must be noted and monitored in ARV therapy. The aims  was analysis risk factor substitution ARV first line in therapy ARV. This study was an analytic longitudinal study with retrospective secondary data analysis in a cohort of patients receiving ARV therapy at the District General Hospital of Buleleng District for the period of 2006-2015 and secondary data from medical records of PLHA patients receiving ART.  Result in this study that the percentage of first-line ARV substitution events is 9.88% (119/1204) who received ARV therapy for the past 11 years. Risk factors that increase the risk of substitution in ARV therapy patients are zidovudine (aOR 4.29 CI 1.31 -2.65 p 0.01), nevirapine (aOR1.86 CI 2.15 - 8.59 p 0.01) and functional working status (aOR 1.46 CI 1.13 - 1.98 p 0.01). 

scholarly journals Tuberculosis incidence among people living with HIV/AIDS with virological failure of antiretroviral therapy in Salvador, Bahia, Brazil

2017 ◽  
Vol 21 (5) ◽  
pp. 562-566 ◽  
Author(s):  
Monaliza Cardozo Rebouças ◽  
Márcio Oliveira da Silva ◽  
Tatiana Haguihara ◽  
Carlos Brites ◽  
Eduardo Martins Netto
Keyword(s):  
Antiretroviral Therapy ◽  
Virological Failure ◽  
People Living With Hiv ◽  
Tuberculosis Incidence ◽  
Living With Hiv ◽  
Hiv Aids

scholarly journals First-line antiretroviral therapy and dyslipidemia in people living with HIV-1 in Cameroon: a cross-sectional study

2011 ◽  
Vol 8 (1) ◽  
pp. 33 ◽  
Author(s):  
Eric Pefura Yone ◽  
Awa Betyoumin ◽  
André Kengne ◽  
François Kaze Folefack ◽  
Jeanne Ngogang
Keyword(s):  
Antiretroviral Therapy ◽  
Cross Sectional Study ◽  
People Living With Hiv ◽  
Sectional Study ◽  
First Line ◽  
Cross Sectional ◽  
Living With Hiv ◽  
Hiv 1

scholarly journals Intermittent HIV-1 Viremia (Blips) and Virological Failure in a Cohort of People Living with HIV from São Paulo, Brazil

2012 ◽  
Vol 26 (9) ◽  
pp. 512-515 ◽  
Author(s):  
Karim Yaqub Ibrahim ◽  
Patricia Recordon-Pinson ◽  
Denis Malvy ◽  
Hervé Fleury ◽  
Aluisio Cotrim Segurado
Keyword(s):  
Virological Failure ◽  
Sao Paulo ◽  
People Living With Hiv ◽  
São Paulo ◽  
Living With Hiv ◽  
Hiv 1

scholarly journals Predictors of Virological Failure after Adherence-Enhancement Counseling among First-Line Adults Living with HIV/AIDS in Kombolcha Town, Northeast Ethiopia

2021 ◽  
Vol Volume 13 ◽  
pp. 91-97
Author(s):  
Getachew Bisetegn ◽  
Mastewal Arefaynie ◽  
Anissa Mohammed ◽  
Zinabu Fentaw ◽  
Amare Muche ◽  
...  
Keyword(s):  
Virological Failure ◽  
First Line ◽  
Northeast Ethiopia ◽  
Living With Hiv ◽  
Hiv Aids

scholarly journals Prevalence and determinants of virological failure, genetic diversity and drug resistance among people living with HIV in a minority area in China: a population-based study

2020 ◽  
Author(s):  
Dan Yuan ◽  
Meijing Liu ◽  
Peng Jia ◽  
Yiping Li ◽  
Yuling Huang ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Virological Failure ◽  
Illicit Drugs ◽  
Clinical Stage ◽  
Venous Blood ◽  
Hiv Treatment ◽  
People Living With Hiv ◽  
Living With Hiv ◽  
Hiv 1

Abstract Background Liangshan Yi Autonomous Prefecture is one of the areas that most severely affected by human immunodeficiency virus (HIV) in China, and virological failure on antiretroviral therapy (ART) is serious in this area. Analyses of prevalence and determinants of ART failure, the genetic diversity and drug resistance among people living with HIV (PLWH) helps improve HIV treatment efficiency and prevent HIV transmission. Methods A total of 5157 PLWH were recruited from 2016 to 2017. The venous blood samples were subjected to RT-PCR, followed by sequencing of the HIV-1 pol gene, targeting the protease and reverse transcriptase fragments. HIV-1 diversity was analyzed using the DNAStar software and drug resistance mutations were analyzed using the Stanford University HIV Drug Resistance Database. Results A total of 2156 (41.81%) PLWH showed virological failure on ART. Males (ORm=1.25), heterosexual behaviors and drug injection (ORm=1.44) and mother to child transmission routes (ORm=1.58), the clinical stage of AIDS (ORm=1.35), having used illicit drugs and shared the needles (1-4 times: ORm=1.34; more than 5 times: ORm=1.52), having ever replaced ART regimen (ORm=1.48) increased the risk of virological failure among PLWH, while higher education lever (ORm=0.77) and ≥12 months on ART (12~36 months: ORm=0.72; ≥36 months: ORm=0.66) was associated with lower likelihood of virological failure. The data revealed that CRF07_BC (1508, 95.62%) were the most common strains, and the drug-resistant rate was 32.10% among PLWH with virological failure in this area. The high frequencies of drug resistance were found in EFV and NVP of NNRTIs, ABC, FTC and 3TC of NRTIs, and TPV/r in PIs. The most common mutations in NNRTIs, NRTIs and PIs were K103N/KN (64.69%), M184V/MV/I (36.29%) and Q58E/QE (4.93%), respectively. Conclusion We concluded that surveillance of virological failure, HIV-1 subtypes, and drug resistance to understand HIV-1 epidemiology and guide modification of ART guidelines, and target prevention and control strategies should be formatted to reduce the virological failure and drug resistance to promote viral suppression and prevent HIV-1 transmission.

INTEGRASE INHIBITORS USE AND CMV INFECTION PREDICT IMMUNE RECOVERY IN PEOPLE LIVING WITH HIV STARTING FIRST-LINE THERAPY

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Massimiliano Fabbiani ◽  
Alberto Borghetti ◽  
Nicola Squillace ◽  
Manuela Colafigli ◽  
Lucia Taramasso ◽  
...  
Keyword(s):  
People Living With Hiv ◽  
Immune Recovery ◽  
Integrase Inhibitors ◽  
Cmv Infection ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy ◽  
Living With Hiv
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