Understanding of Pulmonary Metastases in Pediatric Patients with Differentiated Thyroid Cancer Is Evolving

2021 ◽  
Vol 33 (5) ◽  
pp. 217-220
Author(s):  
Kara D. Meister ◽  
Lisa A. Orloff
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Pediatric Patients ◽  
Pulmonary Metastases

Radioiodide Treatment of Pulmonary Metastases of Differentiated Thyroid Cancer

1979 ◽  
Vol 18 (02) ◽  
pp. 86-90 ◽  
Author(s):  
V. Zamrazil ◽  
D. Pohunková ◽  
S. Röhling ◽  
J. Němec
Keyword(s):  
Thyroid Cancer ◽  
Bone Metastases ◽  
Differentiated Thyroid Cancer ◽  
Pulmonary Metastases ◽  
Survival Rates ◽  
Younger Patients ◽  
131I Uptake ◽  
Young Subjects ◽  
Radioiodide Therapy ◽  
Diagnosis Of Thyroid Cancer

Pulmonary metastases were found in 123 out of 840 patients with thyroid cancer between 1955-1977. 87 patients with pulmonary metastases of differentiated cancer were studied in detail, including an evaluation of prognostically important factors. In 66 of them, the induction of 131I uptake in metastases was attempted, in half of them successfully. Uptake was achieved more frequently in younger subjects, in papillary cancers and in patients with fine pulmonary metastases on chest films. Survival (not corrected for age) was evaluated 10 and 15 years following the diagnosis of thyroid cancer and was found to be 29,1 % and 12,2%, respectively. Significantly higher survival rates were seen in younger patients, in patients with the fine type of pulmonary metastases, in the absence of bone metastases and, particularly, in patients with induced 131I uptake in metastases. Papillary cancers were found to have higher survival rates in males and in young subjects only, in the whole group the survival rates were independent of either microscopic type or sex. It is believed that biologic behaviour of distant (pulmonary) metastases may be influenced by radioiodide therapy.

scholarly journals Pulmonary metastases in differentiated thyroid cancer: efficacy of radioiodine therapy and prognostic factors

2015 ◽  
Vol 173 (3) ◽  
pp. 399-408 ◽  
Author(s):  
Hong-Jun Song ◽  
Zhong-Ling Qiu ◽  
Chen-Tian Shen ◽  
Wei-Jun Wei ◽  
Quan-Yong Luo
Keyword(s):  
Thyroid Cancer ◽  
Prognostic Factors ◽  
Pulmonary Metastasis ◽  
Differentiated Thyroid Cancer ◽  
Radioiodine Therapy ◽  
Pulmonary Metastases ◽  
Lung Metastases ◽  
Whole Body ◽  
Metastatic Node ◽  
Serum Thyroglobulin

ContextData from a large cohort of patients with pulmonary metastases from differentiated thyroid cancer (DTC) were retrospectively analyzed.ObjectiveTo assess the effect of radioiodine therapy and investigate the prognostic factors of survival for patients with pulmonary metastasis secondary to DTC.MethodsA total of 372 patients with pulmonary metastasis from DTC treated with131I entered the study. According to the results of131I whole-body scan (WBS), pulmonary metastases were classified as131I-avid and non-131I-avid. For patients with131I-avid lung metastases, treatment response was measured by three parameters: serum thyroglobulin (Tg) levels, chest computed tomography (CT) and post-therapeutic131I-WBS. Overall survival was calculated by the Kaplan–Meier method. Factors predictive of the outcome were determined by multivariate analyses.ResultsAmong patients demonstrating131I-avid pulmonary metastases (256/372, 68.8%), 156 cases (156/256, 60.9%) showed a significant decrease in serum Tg levels after131I therapy and 138 cases (138/229, 60.3%) showed a reduction in pulmonary metastases on follow-up CT. A complete cure, however, was only achieved in 62 cases (62/256, 24.2%). Multivariate analysis showed that only age, the presence of multiple distant metastases and pulmonary metastatic node size were significant independent variables between the groups of131I-avid and non-131I-avid.ConclusionThis study indicated that, most131I-avid pulmonary metastases from DTC can obtain partial or complete remission after131I therapy. Younger patients (<40 years old) with only pulmonary metastases and small (‘fine miliaric’ or micronodular) metastases appear to have relative favorite outcomes. Patients who do not respond to131I treatment have a worse prognosis.

Risk Stratification of Pediatric Patients with Differentiated Thyroid Cancer: Is Total Thyroidectomy Necessary for Patients at Any Risk?

Thyroid ◽  
2020 ◽  
Vol 30 (4) ◽  
pp. 548-556 ◽  
Author(s):  
Kiminori Sugino ◽  
Mitsuji Nagahama ◽  
Wataru Kitagawa ◽  
Keiko Ohkuwa ◽  
Takashi Uruno ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Risk Stratification ◽  
Total Thyroidectomy ◽  
Differentiated Thyroid Cancer ◽  
Pediatric Patients

Performance of ATA Risk Classification in a Single Center Cohort of Pediatric Patients with Differentiated Thyroid Cancer—a Retrospective Study

2017 ◽  
Vol 41 (5) ◽  
pp. S40
Author(s):  
Raad Alwithenani ◽  
Sarah De Brabandere ◽  
Irina Rachinsky ◽  
S. Danielle Macneil ◽  
Mahmoud Badreddine ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Retrospective Study ◽  
Differentiated Thyroid Cancer ◽  
Pediatric Patients ◽  
Risk Classification ◽  
Single Center

Prognostic factors in pediatric differentiated thyroid cancer patients with pulmonary metastases

2015 ◽  
Vol 28 (7-8) ◽  
Author(s):  
Chandra Sekhar Bal ◽  
Aayushi Garg ◽  
Saurav Chopra ◽  
Sanjana Ballal ◽  
Ramya Soundararajan
Keyword(s):  
Thyroid Cancer ◽  
Prognostic Factors ◽  
Differentiated Thyroid Cancer ◽  
Pulmonary Metastases ◽  
Disease Course ◽  
Factors Associated ◽  
Disease Characteristics ◽  
Surgical Methods ◽  
Disease Free

AbstractThis study was aimed at identifying the prognostic factors predicting remission in pediatric differentiated thyroid cancer (DTC) patients presenting with pulmonary metastases. Little is known about the prognostic factors in reference to pediatric DTC patients presenting with pulmonary metastases.Fifty-three DTC patients aged ≤21 years were diagnosed with pulmonary metastases at initial presentation. The demographic and disease characteristics were compared between the patients who achieved remission and those who did not.During the median follow-up of 72 months, 38 patients became disease free, 14 patients had biochemically and/or structurally persistent disease, and one patient died due to disease progression. Patient age >15 years, presence of macronodular pulmonary metastases, and surgical methods lesser than total/near-total thyroidectomy were identified as factors associated with reduced odds of remission.This study describes the disease course and depicts the disease related prognostic factors in pediatric DTC patients with pulmonary metastases.

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