scholarly journals Brazilian Medicinal Plant Acts on Prostaglandin Level and Helicobacter pylori

2008 ◽  
Vol 11 (4) ◽  
pp. 701-708 ◽  
Author(s):  
Z.P. Lima ◽  
T.R. Calvo ◽  
E.F. Silva ◽  
C.H. Pellizzon ◽  
W. Vilegas ◽  
...  
Antibiotics ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 258
Author(s):  
Corinne Raïssa Ngnameko ◽  
Lucia Marchetti ◽  
Barbara Zambelli ◽  
Antonio Quotadamo ◽  
Davide Roncarati ◽  
...  

The medicinal plant Spathodea campanulata P. Beauv. (Bignoniaceae) has been traditionally applied for the prevention and treatment of diseases of the kidney and urinary system, the skin, the gastrointestinal tract, and inflammation in general. The present work shows for the first time how chemical components from this plant inhibit Helicobacter pylori growth by urease inhibition and modulation of virulence factors. The crude extract and the main fractions of S. campanulata bark were tested on H. pylori isolated strains and the active ones were further fractionated. Fractions and sub-fractions of the plant crude extract were characterized by ultra-high-performance liquid chromatographic tandem high resolution-mass spectrometry detection (UHPLC-HRMS). Several phenolics and triterpenoids were identified. Among the sub-fractions obtained, SB2 showed the capacity to inhibit H. pylori urease in a heterologous bacterial model. One additional sub-fraction (SE3) was able to simultaneously modulate the expression of two adhesins (HopZ and BabA) and one cytotoxin (CagA). The flavonol kaempferol was identified as the most interesting compound that deserves further investigation as a new hit for its capacity to modulate H. pylori virulence factors.


2002 ◽  
Vol 122 (4) ◽  
pp. 291-294 ◽  
Author(s):  
Takahiko ISOBE ◽  
Ayumi OHSAKI ◽  
Kumiko NAGATA

2011 ◽  
Vol 25 (11) ◽  
pp. 1059-1066 ◽  
Author(s):  
M. Hajimahmoodi ◽  
M. Shams-Ardakani ◽  
P. Saniee ◽  
F. Siavoshi ◽  
M. Mehrabani ◽  
...  

2015 ◽  
Vol 159 ◽  
pp. 285-295 ◽  
Author(s):  
Laísa Pinheiro Silva ◽  
Célio Damacena de Angelis ◽  
Flavia Bonamin ◽  
Hélio Kushima ◽  
Francisco José Mininel ◽  
...  

2016 ◽  
Vol 55 (1) ◽  
pp. 603-610 ◽  
Author(s):  
Laure Brigitte Kouitcheu Mabeku ◽  
Bertrand Eyoum Bille ◽  
Thibau Flaurant Tchouangueu ◽  
Eveline Nguepi ◽  
Hubert Leundji

Author(s):  
A. R. Crooker ◽  
W. G. Kraft ◽  
T. L. Beard ◽  
M. C. Myers

Helicobacter pylori is a microaerophilic, gram-negative bacterium found in the upper gastrointestinal tract of humans. There is strong evidence that H. pylori is important in the etiology of gastritis; the bacterium may also be a major predisposing cause of peptic ulceration. On the gastric mucosa, the organism exists as a spiral form with one to seven sheathed flagella at one (usually) or both poles. Short spirals were seen in the first successful culture of the organism in 1983. In 1984, Marshall and Warren reported a coccoid form in older cultures. Since that time, other workers have observed rod and coccal forms in vitro; coccoid forms predominate in cultures 3-7 days old. We sought to examine the growth cycle of H. pylori in prolonged culture and the mode of coccoid body formation.


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