Protein S100B and Brain Lipid-Binding Protein concentrations in the Serum of Recently Concussed Rugby Players

2021 ◽  
Author(s):  
Matthew James Rogatzki ◽  
Jessica E Morgan ◽  
Julien S Baker ◽  
Allan Knox ◽  
Jorge M Serrador
Keyword(s):  
Binding Protein ◽  
Lipid Binding ◽  
Brain Lipid ◽  
Lipid Binding Protein ◽  
Protein S100b ◽  
Rugby Players

Brain lipid–binding protein: a marker of differentiation in neuroblastic tumors

2011 ◽  
Vol 46 (6) ◽  
pp. 1197-1200 ◽  
Author(s):  
Giuseppe Retrosi ◽  
Neil J. Sebire ◽  
Mark Bishay ◽  
Edward M. Kiely ◽  
John Anderson ◽  
...  
Keyword(s):  
Binding Protein ◽  
Protein A ◽  
Lipid Binding ◽  
Brain Lipid ◽  
Lipid Binding Protein ◽  
Neuroblastic Tumors

scholarly journals Brain lipid-binding protein promotes proliferation and modulates cell cycle in C6 rat glioma cells

2017 ◽  
Vol 51 (5) ◽  
pp. 1439-1448
Author(s):  
Xiao Han ◽  
Haoming Li ◽  
Ye Zhang ◽  
Jianbing Qin ◽  
Qingqing Yang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Binding Protein ◽  
Glioma Cells ◽  
Lipid Binding ◽  
Brain Lipid ◽  
Rat Glioma ◽  
Lipid Binding Protein

scholarly journals Brain Lipid Binding Protein (FABP7) as Modulator of Astrocyte Function

2011 ◽  
pp. S49-S60 ◽  
Author(s):  
M. KIPP ◽  
T. CLARNER ◽  
S. GINGELE ◽  
F. POTT ◽  
S. AMOR ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Binding Protein ◽  
Active Role ◽  
Lipid Binding ◽  
Brain Lipid ◽  
Local Inflammation ◽  
Lipid Binding Protein ◽  
Proliferation And Differentiation ◽  
Oligodendrocyte Precursor ◽  
Glial Scarring

Over a century ago, hyperplasia and hypertrophy of astrocytes was noted as a histopathological hallmark of multiple sclerosis and was hypothesized to play an important role in the development and course of this disease. However until today, the factual contribution of astrocytes to multiple sclerosis is elusive. Astrocytes may play an active role during degeneration and demyelination by controlling local inflammation in the CNS, provoking damage of oligodendrocytes and axons, and glial scarring but might also be beneficial by creating a permissive environment for remyelination and oligodendrocyte precursor migration, proliferation, and differentiation. Recent findings from our lab suggest that brain lipid binding protein (FABP7) is implicated in the course of multiple sclerosis and the regulation of astrocyte function. The relevance of our findings and data from other groups are highlighted and discussed in this paper in the context of myelin repair.

scholarly journals Brain Lipid Binding Protein in Axon-Schwann Cell Interactions and Peripheral Nerve Tumorigenesis

2003 ◽  
Vol 23 (6) ◽  
pp. 2213-2224 ◽  
Author(s):  
Shyra J. Miller ◽  
Hongzhen Li ◽  
Tilat A. Rizvi ◽  
Yuan Huang ◽  
Gunnar Johansson ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Peripheral Nerve ◽  
Schwann Cells ◽  
Binding Protein ◽  
Lipid Binding ◽  
Dominant Negative ◽  
Brain Lipid ◽  
Lipid Binding Protein ◽  
Peripheral Nerve Sheath Tumors ◽  
Egfr Expression

ABSTRACT Loss of axonal contact characterizes Schwann cells in benign and malignant peripheral nerve sheath tumors (MPNST) from neurofibromatosis type 1 (NF1) patients. Tumor Schwann cells demonstrate NF1 mutations, elevated Ras activity, and aberrant epidermal growth factor receptor (EGFR) expression. Using cDNA microarrays, we found that brain lipid binding protein (BLBP) is elevated in an EGFR-positive subpopulation of Nf1 mutant mouse Schwann cells (Nf1 −/− TXF) that grows away from axons; BLBP expression was not affected by farnesyltransferase inhibitor, an inhibitor of H-Ras. BLBP was also detected in EGFR-positive cell lines derived from Nf1:p53 double mutant mice and human MPNST. BLBP expression was induced in normal Schwann cells following transfection with EGFR but not H-Ras12V. Furthermore, EGFR-mediated BLBP expression was not inhibited by dominant-negative H-Ras, indicating that BLBP expression is downstream of Ras-independent EGFR signaling. BLBP-blocking antibodies enabled process outgrowth from Nf1 −/− TXF cells and restored interaction with axons, without affecting cell proliferation or migration. Following injury, BLBP expression was induced in normal sciatic nerves when nonmyelinating Schwann cells remodeled their processes. These data suggest that BLBP, stimulated by Ras-independent pathways, regulates Schwann cell-axon interactions in normal peripheral nerve and peripheral nerve tumors.

scholarly journals Ligand Specificity of Brain Lipid-binding Protein

1996 ◽  
Vol 271 (40) ◽  
pp. 24711-24719 ◽  
Author(s):  
Liang Zhong Xu ◽  
Roberto Sánchez ◽  
Andrej Sali ◽  
Nathaniel Heintz
Keyword(s):  
Binding Protein ◽  
Lipid Binding ◽  
Ligand Specificity ◽  
Brain Lipid ◽  
Lipid Binding Protein
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