Mesenchymal stem cell-derived extracellular vesicles suppress hyperoxia-induced transdifferentiation of rat alveolar type 2 epithelial cells

2021 ◽  
Author(s):  
Danyang Ai ◽  
Jieru Shen ◽  
Jiali Sun ◽  
Zhicheng Zhu ◽  
Ruiwei Gao ◽  
...  
Keyword(s):  
Stem Cell ◽  
Epithelial Cells ◽  
Mesenchymal Stem Cell ◽  
Extracellular Vesicles ◽  
Alveolar Type

scholarly journals Bone mesenchymal stem cell-derived extracellular vesicles promote the repair of intervertebral disc degeneration by transferring microRNA-199a

Cell Cycle ◽  
2021 ◽  
Vol 20 (3) ◽  
pp. 256-270
Author(s):  
Tao Wen ◽  
Hongshen Wang ◽  
Yongjin Li ◽  
Yongpeng Lin ◽  
Shuai Zhao ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Extracellular Vesicles ◽  
Intervertebral Disc Degeneration

scholarly journals Uptake and Distribution of Administered Bone Marrow Mesenchymal Stem Cell Extracellular Vesicles in Retina

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 730
Author(s):  
Biji Mathew ◽  
Leianne A. Torres ◽  
Lorea Gamboa Gamboa Acha ◽  
Sophie Tran ◽  
Alice Liu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Extracellular Vesicles ◽  
Time Course ◽  
Ganglion Cells ◽  
Ex Vivo ◽  
Dependent Manner ◽  
Paracrine Effects

Cell replacement therapy using mesenchymal (MSC) and other stem cells has been evaluated for diabetic retinopathy and glaucoma. This approach has significant limitations, including few cells integrated, aberrant growth, and surgical complications. Mesenchymal Stem Cell Exosomes/Extracellular Vesicles (MSC EVs), which include exosomes and microvesicles, are an emerging alternative, promoting immunomodulation, repair, and regeneration by mediating MSC’s paracrine effects. For the clinical translation of EV therapy, it is important to determine the cellular destination and time course of EV uptake in the retina following administration. Here, we tested the cellular fate of EVs using in vivo rat retinas, ex vivo retinal explant, and primary retinal cells. Intravitreally administered fluorescent EVs were rapidly cleared from the vitreous. Retinal ganglion cells (RGCs) had maximal EV fluorescence at 14 days post administration, and microglia at 7 days. Both in vivo and in the explant model, most EVs were no deeper than the inner nuclear layer. Retinal astrocytes, microglia, and mixed neurons in vitro endocytosed EVs in a dose-dependent manner. Thus, our results indicate that intravitreal EVs are suited for the treatment of retinal diseases affecting the inner retina. Modification of the EV surface should be considered for maintaining EVs in the vitreous for prolonged delivery.

scholarly journals Helicobacter pylori Infection of Gastrointestinal Epithelial Cells in vitro Induces Mesenchymal Stem Cell Migration through an NF-κB-Dependent Pathway

PLoS ONE ◽  
2011 ◽  
Vol 6 (12) ◽  
pp. e29007 ◽  
Author(s):  
Jonathan Ferrand ◽  
Philippe Lehours ◽  
Annie Schmid-Alliana ◽  
Francis Mégraud ◽  
Christine Varon
Keyword(s):  
Helicobacter Pylori ◽  
Stem Cell ◽  
Cell Migration ◽  
Epithelial Cells ◽  
Mesenchymal Stem Cell ◽  
Helicobacter Pylori Infection ◽  
Stem Cell Migration ◽  
Dependent Pathway

scholarly journals FP456CD362+ MESENCHYMAL STEM CELL TREATMENT OF KIDNEY DISEASE IN TYPE 2 DIABETIC LEPR DB/DB MICE

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii223-iii224 ◽  
Author(s):  
Satish Kumar Devarapu ◽  
Xie Junhui ◽  
Murthy Darisipudi ◽  
Anais Rocanin Arjo ◽  
Hans Joachim Anders
Keyword(s):  
Stem Cell ◽  
Kidney Disease ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Treatment ◽  
Mesenchymal Stem Cell Treatment ◽  
Type 2 Diabetic

scholarly journals Experimental artefacts can lead to misattribution of bioactivity from soluble mesenchymal stem cell paracrine factors to extracellular vesicles

2020 ◽  
Vol 9 (1) ◽  
pp. 1807674 ◽  
Author(s):  
Thomas E. Whittaker ◽  
Anika Nagelkerke ◽  
Valeria Nele ◽  
Ulrike Kauscher ◽  
Molly M. Stevens
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Extracellular Vesicles ◽  
Paracrine Factors
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