Hashimoto's Thyroiditis Is Not Associated with Increased Risk of Thyroid Cancer in Patients with Thyroid Nodules: A Single-Center Prospective Study

Thyroid ◽  
2010 ◽  
Vol 20 (6) ◽  
pp. 601-606 ◽  
Author(s):  
Cüneyd Anil ◽  
Sibel Goksel ◽  
Alptekin Gursoy
Keyword(s):  
Thyroid Cancer ◽  
Prospective Study ◽  
Hashimoto’S Thyroiditis ◽  
Thyroid Nodules ◽  
Hashimoto's Thyroiditis ◽  
Single Center ◽  
Increased Risk

scholarly journals Prevalence and predictor for malignancy of contralateral thyroid nodules in patients with unilateral PTMC: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Weidi Wang ◽  
Ling-Jun Kong ◽  
Hong-Kun Guo ◽  
Xiang-Jin Chen
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Thyroid Nodules ◽  
Meta Analysis ◽  
Lesion Size ◽  
Cochrane Library ◽  
Categorical Variables ◽  
Hashimoto's Thyroiditis ◽  
Capsular Invasion ◽  
Thyroid Microcarcinoma ◽  
Increased Risk

Background: The presence of clinically negative nodules on the contralateral lobe is common in patients with unilateral papillary thyroid microcarcinoma (PTMC). The appropriate operational strategies of contralateral thyroid nodules remain controversial. In this study, we analyzed clinical features that could be predictors for malignancy of contralateral thyroid nodules coexisting with diagnosed unilateral PTMC. Methods: The literatures published from January 2000 to December 2019 were searched in PubMed, Cochrane Library, Embase, Web of Science, CNKI, and Wan Fang database. Odds ratio (OR) with 95% confidence intervals (CI) were used to describe categorical variables. Heterogeneity among studies was examined by the Q test and I2 test; potential publication bias was detected by Harbord test and ‘trim and fill’ method. Results: 2541 studies were searched and 8 studies were finally included in this meta-analysis. The results showed that the rate of carcinoma in contralateral nodules was 23% (OR=0.23, 95%CI=0.18-0.29). The pooled data indicated that contralateral malignancy was not associated with age, gender, primary lesion size, ipsilateral central lymph node metastasis and multifocality of contralateral lesion. The following variables have correlations with an increased risk of contralateral malignancy: multifocality of primary carcinomas (OR=3.93, 95%CI=2.70-5.73, p<0.0001), capsular invasion (OR=1.61, 95%CI=1.10-2.36, p=0.01), and Hashimoto's thyroiditis (OR=1.57，95%CI=1.13-2.20, P=0.008). Conclusions: Based on our meta-analysis, the rate at which contralateral malignancy are preoperatively misdiagnosed as benign is 23%. The risk factors for contralateral malignancy in unilateral PTMC patients with contralateral clinical negative nodules include multifocality of primary carcinomas, capsular invasion, and Hashimoto's thyroiditis.

Thyroid nodules in childhood‐onset Hashimoto’s thyroiditis: Frequency, risk factors, follow‐up course, and genetic alterations of thyroid cancer

2021 ◽  
Author(s):  
Yun Jeong Lee ◽  
Yeon Jin Cho ◽  
You Joung Heo ◽  
Eun‐Jae Chung ◽  
Young Hun Choi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Thyroid Cancer ◽  
Hashimoto’S Thyroiditis ◽  
Thyroid Nodules ◽  
Genetic Alterations ◽  
Hashimoto's Thyroiditis ◽  
Childhood Onset

Genetic variation in NFE2L2 and SEPS1S associated with increased risk of Hashimoto's thyroiditis

2017 ◽  
Author(s):  
Liliana R Santos ◽  
Cecila Duraes ◽  
Ana Pestana ◽  
Cesar Esteves ◽  
Celestino Neves ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Increased Risk

Role of Pro-inflammatory biomarkers in Hashimoto's thyroiditis: A prospective study

2018 ◽  
Author(s):  
B Ramesh ◽  
B Rajesh ◽  
Reddy B Rajkiran ◽  
G Gayathri ◽  
Reddy M Venkateshwara ◽  
...  
Keyword(s):  
Prospective Study ◽  
Hashimoto’S Thyroiditis ◽  
Inflammatory Biomarkers ◽  
Hashimoto's Thyroiditis ◽  
A Prospective Study

scholarly journals Ultrasonographic Findings of Papillary Thyroid Cancer with or without Hashimoto's Thyroiditis

2010 ◽  
Vol 63 (2) ◽  
pp. 97
Author(s):  
Jun Young Park ◽  
Tae Hyun Lee ◽  
Dong Hee Park
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Papillary Thyroid

scholarly journals Role of biomarkers in predicting the occurrence of thyroid neoplasms in radiation-exposed children

2018 ◽  
Vol 25 (4) ◽  
pp. 481-491
Author(s):  
Joseph M Shulan ◽  
Leonid Vydro ◽  
Arthur B Schneider ◽  
Dan V Mihailescu
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Nodules ◽  
Subsequent Development ◽  
Thyroid Neoplasms ◽  
Childhood Cancer Survivors ◽  
Malignant Neoplasms ◽  
Increased Risk ◽  
Need To Evaluate

With increasing numbers of childhood cancer survivors who were treated with radiation, there is a need to evaluate potential biomarkers that could signal an increased risk of developing thyroid cancer. We aimed to examine the relationships between thyrotropin and thyroglobulin levels and the risk of developing thyroid nodules and cancer in a cohort of radiation-exposed children. 764 subjects who were irradiated in the neck area as children were examined and followed for up to 25 years. All subjects underwent a clinical examination, measurements of thyrotropin, thyroglobulin levels and thyroid imaging. At baseline, 216 subjects had thyroid nodules and 548 did not. Of those with nodules, 176 underwent surgery with 55 confirmed thyroid cancers. During the follow-up, 147 subjects developed thyroid nodules including 22 with thyroid cancer. Thyroglobulin levels were higher in subjects with prevalent thyroid nodules (26.1 ng/mL vs 9.37 ng/mL; P < 0.001) and in those who had an initial normal examination but later developed thyroid nodules (11.2 ng/mL vs 8.87 ng/mL; P = 0.017). There was no relationship between baseline thyrotropin levels and the prevalent presence or absence of thyroid nodules, whether a prevalent neoplasm was benign or malignant, subsequent development of thyroid nodules during follow-up or whether an incident nodule was benign or malignant. In conclusion, in radiation-exposed children, higher thyroglobulin levels indicated an increased risk of developing thyroid nodules but did not differentiate between benign and malignant neoplasms. There was no association between the baseline TSH level and the risk of developing thyroid nodules or cancer.

scholarly journals Association between Hashimoto’s Thyroiditis and Thyroid Cancer in 64,628 Patients

2017 ◽  
Vol 7 ◽  
Author(s):  
Christina Resende de Paiva ◽  
Christian Grønhøj ◽  
Ulla Feldt-Rasmussen ◽  
Christian von Buchwald
Keyword(s):  
Thyroid Cancer ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis

Hashimoto's thyroiditis and thyroid cancer: Indications for operation

1980 ◽  
Vol 140 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Orlo H. Clark ◽  
Frances S. Greenspan ◽  
J.Englebert Dunphy
Keyword(s):  
Thyroid Cancer ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Indications For Operation
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