Genetic variation in NFE2L2 and SEPS1S associated with increased risk of Hashimoto's thyroiditis

2017 ◽  
Author(s):  
Liliana R Santos ◽  
Cecila Duraes ◽  
Ana Pestana ◽  
Cesar Esteves ◽  
Celestino Neves ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Increased Risk

scholarly journals Prevalence and predictor for malignancy of contralateral thyroid nodules in patients with unilateral PTMC: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Weidi Wang ◽  
Ling-Jun Kong ◽  
Hong-Kun Guo ◽  
Xiang-Jin Chen
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Thyroid Nodules ◽  
Meta Analysis ◽  
Lesion Size ◽  
Cochrane Library ◽  
Categorical Variables ◽  
Hashimoto's Thyroiditis ◽  
Capsular Invasion ◽  
Thyroid Microcarcinoma ◽  
Increased Risk

Background: The presence of clinically negative nodules on the contralateral lobe is common in patients with unilateral papillary thyroid microcarcinoma (PTMC). The appropriate operational strategies of contralateral thyroid nodules remain controversial. In this study, we analyzed clinical features that could be predictors for malignancy of contralateral thyroid nodules coexisting with diagnosed unilateral PTMC. Methods: The literatures published from January 2000 to December 2019 were searched in PubMed, Cochrane Library, Embase, Web of Science, CNKI, and Wan Fang database. Odds ratio (OR) with 95% confidence intervals (CI) were used to describe categorical variables. Heterogeneity among studies was examined by the Q test and I2 test; potential publication bias was detected by Harbord test and ‘trim and fill’ method. Results: 2541 studies were searched and 8 studies were finally included in this meta-analysis. The results showed that the rate of carcinoma in contralateral nodules was 23% (OR=0.23, 95%CI=0.18-0.29). The pooled data indicated that contralateral malignancy was not associated with age, gender, primary lesion size, ipsilateral central lymph node metastasis and multifocality of contralateral lesion. The following variables have correlations with an increased risk of contralateral malignancy: multifocality of primary carcinomas (OR=3.93, 95%CI=2.70-5.73, p<0.0001), capsular invasion (OR=1.61, 95%CI=1.10-2.36, p=0.01), and Hashimoto's thyroiditis (OR=1.57，95%CI=1.13-2.20, P=0.008). Conclusions: Based on our meta-analysis, the rate at which contralateral malignancy are preoperatively misdiagnosed as benign is 23%. The risk factors for contralateral malignancy in unilateral PTMC patients with contralateral clinical negative nodules include multifocality of primary carcinomas, capsular invasion, and Hashimoto's thyroiditis.

Risk of Thyroid Disorders in Patients with Gout and Hyperuricemia

2019 ◽  
Vol 51 (08) ◽  
pp. 522-530
Author(s):  
Jian Xu ◽  
Bin Wang ◽  
Qian Li ◽  
Qiuming Yao ◽  
Xi Jia ◽  
...  
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Thyroid Dysfunction ◽  
Meta Analysis ◽  
Thyroid Autoimmunity ◽  
Cross Sectional Study ◽  
Hashimoto's Thyroiditis ◽  
Thyroid Disorders ◽  
Sectional Study ◽  
Cross Sectional ◽  
Increased Risk

AbstractThe risk of thyroid autoimmunity and thyroid dysfunction among patients with gout and hyperuricemia has not been well defined. This study was undertaken to examine the impact of gout and hyperuricemia on risk of thyroid disorders including thyroid autoimmunity and thyroid dysfunction. A population-based cross-sectional study was conducted to assess the risk of thyroid autoimmunity and thyroid dysfunction related to gout and hyperuricemia, which included 115 gout patients, 439 hyperuricemic patients, and 2 254 individuals without gout and hyperuricemia. A systematic review and meta-analysis of 14 observational studies was also done to systematically evaluate the risk of thyroid dysfunction among patients with gout and hyperuricemia. Findings from the cross-sectional study suggested a significantly increased risk of hypothyroidism among female gout patients (OR=2.44, 95% CI 1.15–5.17, p=0.02). Besides, gout could also substantially increase risk of Hashimoto’s thyroiditis in women (OR=3.15, 95% CI 1.53–6.49, p=0.002). The meta-analysis proved a considerably increased risk of hypothyroidism among both gout patients (OR=1.51, 95% CI 1.23–1.85, p<0.001) and hyperuricemic patients (OR=1.34, 95% CI 1.11–1.61, p=0.002). Moreover, this meta-analysis also suggested that gout could also significantly increase the risk of hyperthyroidism (OR=1.25, 95% CI 1.06–1.48, p=0.01). The findings from the study suggest increasing risk of hypothyroidism and Hashimoto’s thyroiditis among gout patients. Moreover, gout but not hyperuricemia is linked to increased risk of hyperthyroidism. More studies are warranted to elucidate the influence of gout and hyperuricemia on thyroid disorders.

scholarly journals Profile of Hashimoto's Thyroiditis in Sri Lankans: Is There an Increased Risk of Ancillary Pathologies in Hashimoto's Thyroiditis?

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Eranga Himalee Siriweera ◽  
Neelakanthi Vajira Illangakoon Ratnatunga
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Age Group ◽  
Benign Neoplasms ◽  
Benign Lesions ◽  
Cell Adenoma ◽  
Male Ratio ◽  
Increased Risk ◽  
The Mean ◽  
Thyroid Malignancies

Hashimoto's thyroiditis has been reported to be associated with many neoplastic and nonneoplastic thyroid pathologies. This retrospective study aims to determine the demographic profile of Hashimoto's thyroiditis in Sri Lankans, document ancillary pathologies in Hashimoto's thyroiditis, and determine whether there is an increased risk of occurrence of malignancies, benign neoplasms, and nonneoplastic benign lesions in Hashimoto's thyroiditis by comparing with thyroids showing multinodular goiters, follicular adenomas, and colloid nodules. The mean age of Hashimoto's thyroiditis is 43.3 years with the majority in the 41 to 60 year age group and a female to male ratio of 10.3 : 1. This study revealed a statistically significant increase of thyroid malignancies in association with Hashimoto's thyroiditis. The association of Papillary carcinoma, Non-Hodgkin's lymphoma, and Hurthle cell adenoma with Hashimoto's thyroiditis was statistically significant.

Lipoatrophy Is Associated with an Increased Risk of Hashimoto's Thyroiditis and Coeliac Disease in Female Patients with Type 1 Diabetes

2013 ◽  
Vol 79 (6) ◽  
pp. 368-372 ◽  
Author(s):  
Burak Salgin ◽  
Thomas Meissner ◽  
Peter Beyer ◽  
Holger Haberland ◽  
Martin Borkenstein ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Coeliac Disease ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Female Patients ◽  
Increased Risk

Hashimoto’s Thyroiditis is an Important Risk Factor of Papillary Thyroid Microcarcinoma in Younger Adults

2017 ◽  
Vol 49 (10) ◽  
pp. 732-738 ◽  
Author(s):  
Yujuan Liu ◽  
Chengqian Li ◽  
Wenjuan Zhao ◽  
Yangang Wang
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Conditional Logistic Regression ◽  
Papillary Thyroid Microcarcinoma ◽  
Hashimoto's Thyroiditis ◽  
Thyroid Antibodies ◽  
Papillary Thyroid ◽  
Younger Adults ◽  
Autoimmune Thyroid ◽  
Thyroid Microcarcinoma ◽  
Increased Risk

AbstractThe association between autoimmune thyroid disease and thyroid cancer remains unclear. We performed a matched case-control study to assess the association between Hashimoto’s thyroiditis and papillary thyroid microcarcinoma (PTMC). A total of 927 PTMC cases and 927 age- and gender- matched controls selected from the same population were recruited. Odds ratio (OR) with 95% confidence interval (95% CI) was used to assess the strength of the association between Hashimoto’s thyroiditis and PTMC. Conditional logistic regression analysis was carried out, and stratified analyses by age, gender and types of thyroid antibodies were also performed. Hashimoto’s thyroiditis was significantly associated with increased risk of PTMC (OR=1.87, 95% CI 1.49–2.34, p<0.001). Stratified analysis by thyroid antibodies also found obvious associations of PTMC risk with TPOAb positivity (OR=1.58, p=0.001) and TGAb positivity (OR=2.35, p<0.001). Stratified analyses by age showed that the association between Hashimoto’s thyroiditis and PTMC risk was more significant in younger adults aged between 18 and 30 years (OR=11.48, p<0.001). Further stratified analyses by thyroid antibodies also found that the associations of PTMC risk with TPOAb positivity or TGAb positivity were more significant in younger adults aged between 18 and 30, and the ORs were 8.27 (p<0.001) and 12.71 (p<0.001), respectively. This study suggests an obvious relationship between Hashimoto’s thyroiditis and PTMC risk, and Hashimoto’s thyroiditis is an important risk of PTMC in younger adults.

Micropapillary Thyroid Carcinoma and Hashimoto's Thyroiditis

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P40-P40
Author(s):  
Michael Navid Pakdaman ◽  
Michael P Hier ◽  
Martin J Black ◽  
Michael Tamilia ◽  
Richard J Payne
Keyword(s):  
Thyroid Carcinoma ◽  
Hashimoto’S Thyroiditis ◽  
Statistical Significance ◽  
Hashimoto's Thyroiditis ◽  
P Value ◽  
Exact Test ◽  
Increased Risk ◽  
Chi Squared ◽  
Pathology Reports ◽  
The Relationship

Objective An increase in papillary thyroid carcinoma in patients with Hashimoto's thyroiditis has been described. We have yet to find literature discussing a relationship with micropapillary thyroid carcinoma(MPC). Our objective is (1) to assess the relationship between Papillary Microcarcinoma and Hashimoto's Thyroiditis in thyroids without malignant disease, (2) compare effect of the presence of Hashimoto's on prognostic factors in patients. Methods Pathology reports were reviewed for consecutive patients undergoing total thyroidectomy over a 6-year period from 2002 to 2007. Patients with benign pathologies were included. Patients with MPC and no other malignancy were also included. This lead to a cohort of 314 patients. Statistical significance was calculated using Fisher's exact test and a chi-squared analysis. Results Out of the 314 patients, 98 were positive for Hashimoto's thyroiditis on biopsy of the removed thyroid. 58% of the patients with Hashimoto's thyroiditis had an incidental MPC, as compared to 42% of patients where Hashimoto's was not found. Additionally, in Hashimoto patients, 61% of the MPCs were multifocal versus 43% multifocal in the non-Hashimoto group (p-value <0.05 in each comparison). Bilaterality of MPC was also increased in patients with Hashimoto's (22% vs 39%). Conclusions Patients with Hashimoto's thyroiditis in this study had an incidence of MPC of 58%, which is significantly greater than the 42% in those without. Hashimoto's was also associated with an increased risk of bilaterality and multifocality. Studies are needed to further corroborate these findings.

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