The Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diets Are Associated with Less Cognitive Decline and a Lower Risk of Alzheimer's Disease—A Review

ABSTRACT As there is currently no cure for dementia, there is an urgent need for preventive strategies. The current review provides an overview of the existing evidence examining the associations of the Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diets and their dietary components with cognitive decline, dementia, and Alzheimer's disease (AD). A systematic search was conducted within Ovid Medline for studies published up to 27 March 2019 and reference lists from existing reviews and select articles were examined to supplement the electronic search results. In total, 56 articles were included. Higher adherence to the Mediterranean diet was associated with better cognitive scores in 9 of 12 cross-sectional studies, 17 of 25 longitudinal studies, and 1 of 3 trials. Higher adherence to the DASH diet was associated with better cognitive function in 1 cross-sectional study, 2 of 5 longitudinal studies, and 1 trial. Higher adherence to the MIND diet was associated with better cognitive scores in 1 cross-sectional study and 2 of 3 longitudinal studies. Evidence on the association of these dietary patterns with dementia in general was limited. However, higher adherence to the Mediterranean diet was associated with a lower risk of AD in 1 case-control study and 6 of 8 longitudinal studies. Moreover, higher adherence to the DASH or MIND diets was associated with a lower AD risk in 1 longitudinal study. With respect to the components of these dietary patterns, olive oil may be associated with less cognitive decline. In conclusion, current scientific evidence suggests that higher adherence to the Mediterranean, DASH, or MIND diets is associated with less cognitive decline and a lower risk of AD, where the strongest associations are observed for the MIND diet.

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The MIND (Mediterranean-DASH Diet Intervention for Neurodegenerative Delay) and Mediterranean Diets are differently associated with psychosomatic complaints profile in adults: Results from SEPAHAN Cross-sectional study

Mediterranean Journal of Nutrition and Metabolism ◽

10.3233/mnm-200426 ◽

2020 ◽

Vol 13 (4) ◽

pp. 341-359

Author(s):

Fahimeh Haghighatdoost ◽

Awat Feizi ◽

Ahmad Esmaillzadeh ◽

Ammar Hassanzadeh Keshteli ◽

Hamidreza Roohafza ◽

...

Keyword(s):

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Dash Diet ◽

Psychosomatic Complaints ◽

Diet Intervention ◽

Validated Questionnaire ◽

The Mediterranean ◽

The Mind ◽

Mind Diet

BACKGROUND: In spite of an obvious association between diet and mental health, there is only few report regarding the association between diet and psychosomatic complaints. OBJECTIVE: To investigate the association of the Mediterranean-DASH diet intervention for neurodegenerative delay (MIND) diet with psychosomatic complaints profile in comparison with the Mediterranean diet (aMED). METHODS: In this cross-sectional study on 2818 Isfahanian adults, a validated dish-based food frequency questionnaire was used to assess dietary intakes. Psychosomatic complaints profile was evaluated through a self-administered Persian validated questionnaire by using exploratory factor analysis. RESULTS: After controlling for potential confounders, individuals in the highest quintile of the MIND diet had lower risk for experiencing psychological (odds ratio (OR) = 0.60, 95% confidence interval (CI): 0.42, 0.86; P trend < 0.0001), and pharyngeal-respiratory (OR = 0.57, 95% CI: 0.41, 0.79; P = 0.002). The association for neuro-skeletal complaints was marginally significant (OR = 0.66, 95% CI: 0.43, 1.03; P = 0.093). The aMED diet tended to lower gastrointestinal complaints (OR = 0.68, 95% CI: 0.46, 1.01; P = 0.062). CONCLUSION: The MIND diet was inversely associated with different psychosomatic complaints risk, but no evidence of such an association for the MED diet was observed.

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Associations between adherence to MIND diet and metabolic syndrome and general and abdominal obesity: a cross-sectional study

Diabetology & Metabolic Syndrome ◽

10.1186/s13098-020-00611-6 ◽

2020 ◽

Vol 12 (1) ◽

Author(s):

Saba Mohammadpour ◽

Parivash Ghorbaninejad ◽

Nasim Janbozorgi ◽

Sakineh Shab-Bidar

Keyword(s):

Metabolic Syndrome ◽

Abdominal Obesity ◽

Cross Sectional Study ◽

Inverse Association ◽

Sectional Study ◽

General Obesity ◽

Cross Sectional ◽

The Mind ◽

Diet Score ◽

Mind Diet

Abstract Background There is a lack of studies examining the association between Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) and metabolic syndrome (MetS) and obesity. Thus, this study aimed to investigate the association of adherence to the MIND diet with MetS and general and abdominal obesity. Methods This cross-sectional study was performed on 836 Iranian adults, 18–75 years old. A 167-item food frequency questionnaire (FFQ) was used to assess dietary intakes of participants. Anthropometric measurements, blood pressure, fasting blood glucose and lipid profile of each participant were recorded. The guidelines of the National Cholesterol Education Program Adult Treatment Panel III (ATP III) was used to define MetS. Results Mean age of study participants was 47.7 ± 10.7 years. The prevalence of MetS was 36.1% and mean body mass index (BMI) and waist circumference (WC) was 27.7 ± 4.69 kg/m2 and 92.0 ± 12.4 cm respectively. Those who were in the third tertile of the MIND diet score compared to the first tertile had 12% lower odds of having the MetS (ORs: 0.88; 95% CI 0.62–1.24) but the association was not significant (P = 0.77). There was a significant inverse association between the MIND diet score and odds of reduced high-density lipoprotein cholesterol (HDL-C) (ORs: 0.59; 95% CI 0.41–0.85; P = 0.008) and general obesity (ORs: 1.190.80–1.78; 95% CI 0.80–1.78; P = 0.02) in crude model and after controlling for confounders. Conclusions We found that the MIND diet score is inversely associated with odds of reduced HDL and general obesity in Iranian adults.

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Interactions between caveolin 1 polymorphism and the Mediterranean and Mediterranean-DASH Intervention for Neurodegenerative Delay diet (MIND) diet on metabolic dyslipidemia in overweight and obese adult women: a cross-sectional study

BMC Research Notes ◽

10.1186/s13104-021-05777-4 ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Nasim Khatibi ◽

Atieh Mirzababaei ◽

Farideh Shiraseb ◽

Faezeh Abaj ◽

Fariba Koohdani ◽

...

Keyword(s):

Plasma Membranes ◽

Metabolic Diseases ◽

Cell Types ◽

Cross Sectional Study ◽

Adult Women ◽

Cross Sectional ◽

Caveolin 1 ◽

The Mediterranean ◽

The Mind ◽

Mind Diet

Abstract Objective The increased prevalence of metabolic dyslipidemia (MD) and its association with a variety of disorders raised a lot of attention to its management. Caveolin 1 (CAV1) the key protein in the caval structure of plasma membranes is many cell types that play an important role in its function. (CAV1) is a known gene associated with obesity. Today, a novel diet recognized as the Mediterranean and Mediterranean-DASH Intervention for Neurodegenerative Delay diet (MIND) is reported to have a positive effect on overall health. Hence, we aimed to investigate the interactions between CAV1 polymorphism and MIND diet on the MD in overweight and obese patients. Results Remarkably, there was a significant interaction between the MIND diet and CAV1 rs3807992 for dyslipidemia (β = − 0.25 ± 132, P = 0.05) in the crude model. Whereby, subjects with dominant alleles had a lower risk of dyslipidemia and risk allele carriers with higher adherence to the MIND diet may exhibit the lower dyslipidemia. This study presented the CAV1 gene as a possible genetic marker in recognizing people at higher risks for metabolic diseases. It also indicated that using the MIND diet may help in improving dyslipidemia through providing a probable interaction with CAV1 rs3807992 polymorphism.

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Interactions between Caveolin 1 polymorphism and the Mediterranean and Mediterranean-DASH Intervention for Neurodegenerative Delay diet (MIND) diet on Metabolic dyslipidemia in overweight and obese adult women: a cross-sectional study

10.21203/rs.3.rs-322306/v1 ◽

2021 ◽

Author(s):

Nasim Khatibi ◽

Atiyeh Mirzababaei ◽

farideh shiraseb ◽

Faezeh Abaj ◽

Fariba koohdani ◽

...

Keyword(s):

Metabolic Diseases ◽

Cross Sectional Study ◽

Adult Women ◽

Cross Sectional ◽

Caveolin 1 ◽

Crude Model ◽

The Mediterranean ◽

The Mind ◽

Positive Effect ◽

Mind Diet

Abstract Objective: A higher incidence of metabolic dyslipidemia (MD) and its association with many diseases attracted considerable attention to its control. Caveolin 1 (CAV1) is a known gene associated with obesity. Today, a novel diet recognized as the Mediterranean and Mediterranean-DASH Intervention for Neurodegenerative Delay diet (MIND( is reported to have a positive effect on overall health. Hence, we aimed to investigate the interactions between CAV1 polymorphism and MIND diet on the MD in overweight and obese patients.Results: Remarkably, there was a significant interaction between the MIND diet and CAV1 rs3807992 for dyslipidemia (β=-0.25±132, P=0.05) in the crude model. Whereby, subjects with dominant alleles had a lower risk of dyslipidemia and risk allele carriers with higher adherence to MIND diet may exhibit the lower dyslipidemia.This study presented the CAV1 gene as a possible genetic marker in recognizing people at higher risks for metabolic diseases. It also indicated that using the MIND diet may help in improving dyslipidemia through providing a probable interaction with CAV1 rs3807992 polymorphism.

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